Brain Gene Silencing with Cationic Amino-Capped Poly(ethylene glycol) Polyplexes

Therapeutic gene silencing in the brain is usually achieved using highly invasive intracranial administration methods and/or comparatively toxic vectors. In this work, we use a relatively biocompatible vector: poly(ethylene glycol) star-shaped polymer capped with amine groups (4APPA) via the nose to...

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Detalles Bibliográficos
Autores principales: Alamoudi, Abdullah A., Méndez, Paula A., Workman, David, Schätzlein, Andreas G., Uchegbu, Ijeoma F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9496157/
https://www.ncbi.nlm.nih.gov/pubmed/36140283
http://dx.doi.org/10.3390/biomedicines10092182

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9496157/
https://www.ncbi.nlm.nih.gov/pubmed/36140283
http://dx.doi.org/10.3390/biomedicines10092182

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