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Application of Metal–Organic Framework in Diagnosis and Treatment of Diabetes
Diabetes-related chronic wounds are often accompanied by a poor wound-healing environment such as high glucose, recurrent infections, and inflammation, and standard wound treatments are fairly limited in their ability to heal these wounds. Metal–organic frameworks (MOFs) have been developed to impro...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9496218/ https://www.ncbi.nlm.nih.gov/pubmed/36139080 http://dx.doi.org/10.3390/biom12091240 |
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author | Gao, Qian Bai, Que Zheng, Caiyun Sun, Na Liu, Jinxi Chen, Wenting Hu, Fangfang Lu, Tingli |
author_facet | Gao, Qian Bai, Que Zheng, Caiyun Sun, Na Liu, Jinxi Chen, Wenting Hu, Fangfang Lu, Tingli |
author_sort | Gao, Qian |
collection | PubMed |
description | Diabetes-related chronic wounds are often accompanied by a poor wound-healing environment such as high glucose, recurrent infections, and inflammation, and standard wound treatments are fairly limited in their ability to heal these wounds. Metal–organic frameworks (MOFs) have been developed to improve therapeutic outcomes due to their ease of engineering, surface functionalization, and therapeutic properties. In this review, we summarize the different synthesis methods of MOFs and conduct a comprehensive review of the latest research progress of MOFs in the treatment of diabetes and its wounds. State-of-the-art in vivo oral hypoglycemic strategies and the in vitro diagnosis of diabetes are enumerated and different antimicrobial strategies (including physical contact, oxidative stress, photothermal, and related ions or ligands) and provascular strategies for the treatment of diabetic wounds are compared. It focuses on the connections and differences between different applications of MOFs as well as possible directions for improvement. Finally, the potential toxicity of MOFs is also an issue that we cannot ignore. |
format | Online Article Text |
id | pubmed-9496218 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94962182022-09-23 Application of Metal–Organic Framework in Diagnosis and Treatment of Diabetes Gao, Qian Bai, Que Zheng, Caiyun Sun, Na Liu, Jinxi Chen, Wenting Hu, Fangfang Lu, Tingli Biomolecules Review Diabetes-related chronic wounds are often accompanied by a poor wound-healing environment such as high glucose, recurrent infections, and inflammation, and standard wound treatments are fairly limited in their ability to heal these wounds. Metal–organic frameworks (MOFs) have been developed to improve therapeutic outcomes due to their ease of engineering, surface functionalization, and therapeutic properties. In this review, we summarize the different synthesis methods of MOFs and conduct a comprehensive review of the latest research progress of MOFs in the treatment of diabetes and its wounds. State-of-the-art in vivo oral hypoglycemic strategies and the in vitro diagnosis of diabetes are enumerated and different antimicrobial strategies (including physical contact, oxidative stress, photothermal, and related ions or ligands) and provascular strategies for the treatment of diabetic wounds are compared. It focuses on the connections and differences between different applications of MOFs as well as possible directions for improvement. Finally, the potential toxicity of MOFs is also an issue that we cannot ignore. MDPI 2022-09-05 /pmc/articles/PMC9496218/ /pubmed/36139080 http://dx.doi.org/10.3390/biom12091240 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Gao, Qian Bai, Que Zheng, Caiyun Sun, Na Liu, Jinxi Chen, Wenting Hu, Fangfang Lu, Tingli Application of Metal–Organic Framework in Diagnosis and Treatment of Diabetes |
title | Application of Metal–Organic Framework in Diagnosis and Treatment of Diabetes |
title_full | Application of Metal–Organic Framework in Diagnosis and Treatment of Diabetes |
title_fullStr | Application of Metal–Organic Framework in Diagnosis and Treatment of Diabetes |
title_full_unstemmed | Application of Metal–Organic Framework in Diagnosis and Treatment of Diabetes |
title_short | Application of Metal–Organic Framework in Diagnosis and Treatment of Diabetes |
title_sort | application of metal–organic framework in diagnosis and treatment of diabetes |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9496218/ https://www.ncbi.nlm.nih.gov/pubmed/36139080 http://dx.doi.org/10.3390/biom12091240 |
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