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Associations Between Soluble fms‐Like Tyrosine Kinase‐1 and Placental Growth Factor and Disease Severity Among Women With Preterm Eclampsia and Preeclampsia

BACKGROUND: The angiogenic factors soluble fms‐like tyrosine kinase‐1 (sFlt‐1) and placental growth factor (PlGF) are postulated to be pathogenic disease drivers of preeclampsia. If true, then circulating levels should become more deranged with increasing disease severity. METHODS AND RESULTS: We in...

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Autores principales: Hastie, Roxanne, Bergman, Lina, Walker, Susan P., Kaitu'u‐Lino, Tu'uhevaha, Hannan, Natalie J., Brownfoot, Fiona, Schell, Sonja, Harper, Alesia, Cannon, Ping, Cluver, Catherine A., Tong, Stephen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9496300/
https://www.ncbi.nlm.nih.gov/pubmed/35943054
http://dx.doi.org/10.1161/JAHA.121.024395
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author Hastie, Roxanne
Bergman, Lina
Walker, Susan P.
Kaitu'u‐Lino, Tu'uhevaha
Hannan, Natalie J.
Brownfoot, Fiona
Schell, Sonja
Harper, Alesia
Cannon, Ping
Cluver, Catherine A.
Tong, Stephen
author_facet Hastie, Roxanne
Bergman, Lina
Walker, Susan P.
Kaitu'u‐Lino, Tu'uhevaha
Hannan, Natalie J.
Brownfoot, Fiona
Schell, Sonja
Harper, Alesia
Cannon, Ping
Cluver, Catherine A.
Tong, Stephen
author_sort Hastie, Roxanne
collection PubMed
description BACKGROUND: The angiogenic factors soluble fms‐like tyrosine kinase‐1 (sFlt‐1) and placental growth factor (PlGF) are postulated to be pathogenic disease drivers of preeclampsia. If true, then circulating levels should become more deranged with increasing disease severity. METHODS AND RESULTS: We investigated the association between circulating sFlt‐1 and PlGF levels and severe adverse maternal outcomes among 348 women with preeclampsia. Compared with 125 women with preeclampsia without severe features, 25 women with preeclampsia and any of hemolysis, elevated liver enzymes, low platelet count syndrome, disseminated intravascular coagulation, or severe renal involvement had sFlt‐1 levels that were 2.63‐fold higher (95% CI, 1.81–3.82), sFlt‐1/PlGF levels that were 10.07‐fold higher (95% CI, 5.36–18.91) and PlGF levels that were 74% lower (adjusted fold change, 0.26 [95% CI, 0.18–0.39]). Compared with 125 women with preeclampsia without severe features, 37 with eclampsia had sFlt‐1 levels that were 2‐fold higher (2.02 [95% CI, 1.32–3.09]), sFlt‐1/PIGF levels that were 4.71‐fold higher (95% CI, 2.30–9.66) and PIGF levels that were 63% lower (0.43‐fold change [95% CI, 0.27–0.68]). Compared with those without severe features, preeclampsia with severe hypertension (n=146) was also associated with altered angiogenic levels (sFlt‐1, 1.71‐fold change [95% CI, 1.39–2.11]; sFlt/PlGF, 2.91 [95% CI, 2.04–4.15]; PlGF, 0.59 [95%CI 0.47–0.74]). We also found that sFlt‐1 and PlGF levels were altered by the number of maternal complications experienced. CONCLUSIONS: Further angiogenic imbalance among women with preeclampsia is likely a pathogenic disease driver responsible for the life‐threatening maternal complications.
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spelling pubmed-94963002022-09-30 Associations Between Soluble fms‐Like Tyrosine Kinase‐1 and Placental Growth Factor and Disease Severity Among Women With Preterm Eclampsia and Preeclampsia Hastie, Roxanne Bergman, Lina Walker, Susan P. Kaitu'u‐Lino, Tu'uhevaha Hannan, Natalie J. Brownfoot, Fiona Schell, Sonja Harper, Alesia Cannon, Ping Cluver, Catherine A. Tong, Stephen J Am Heart Assoc Original Research BACKGROUND: The angiogenic factors soluble fms‐like tyrosine kinase‐1 (sFlt‐1) and placental growth factor (PlGF) are postulated to be pathogenic disease drivers of preeclampsia. If true, then circulating levels should become more deranged with increasing disease severity. METHODS AND RESULTS: We investigated the association between circulating sFlt‐1 and PlGF levels and severe adverse maternal outcomes among 348 women with preeclampsia. Compared with 125 women with preeclampsia without severe features, 25 women with preeclampsia and any of hemolysis, elevated liver enzymes, low platelet count syndrome, disseminated intravascular coagulation, or severe renal involvement had sFlt‐1 levels that were 2.63‐fold higher (95% CI, 1.81–3.82), sFlt‐1/PlGF levels that were 10.07‐fold higher (95% CI, 5.36–18.91) and PlGF levels that were 74% lower (adjusted fold change, 0.26 [95% CI, 0.18–0.39]). Compared with 125 women with preeclampsia without severe features, 37 with eclampsia had sFlt‐1 levels that were 2‐fold higher (2.02 [95% CI, 1.32–3.09]), sFlt‐1/PIGF levels that were 4.71‐fold higher (95% CI, 2.30–9.66) and PIGF levels that were 63% lower (0.43‐fold change [95% CI, 0.27–0.68]). Compared with those without severe features, preeclampsia with severe hypertension (n=146) was also associated with altered angiogenic levels (sFlt‐1, 1.71‐fold change [95% CI, 1.39–2.11]; sFlt/PlGF, 2.91 [95% CI, 2.04–4.15]; PlGF, 0.59 [95%CI 0.47–0.74]). We also found that sFlt‐1 and PlGF levels were altered by the number of maternal complications experienced. CONCLUSIONS: Further angiogenic imbalance among women with preeclampsia is likely a pathogenic disease driver responsible for the life‐threatening maternal complications. John Wiley and Sons Inc. 2022-08-09 /pmc/articles/PMC9496300/ /pubmed/35943054 http://dx.doi.org/10.1161/JAHA.121.024395 Text en © 2022 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Research
Hastie, Roxanne
Bergman, Lina
Walker, Susan P.
Kaitu'u‐Lino, Tu'uhevaha
Hannan, Natalie J.
Brownfoot, Fiona
Schell, Sonja
Harper, Alesia
Cannon, Ping
Cluver, Catherine A.
Tong, Stephen
Associations Between Soluble fms‐Like Tyrosine Kinase‐1 and Placental Growth Factor and Disease Severity Among Women With Preterm Eclampsia and Preeclampsia
title Associations Between Soluble fms‐Like Tyrosine Kinase‐1 and Placental Growth Factor and Disease Severity Among Women With Preterm Eclampsia and Preeclampsia
title_full Associations Between Soluble fms‐Like Tyrosine Kinase‐1 and Placental Growth Factor and Disease Severity Among Women With Preterm Eclampsia and Preeclampsia
title_fullStr Associations Between Soluble fms‐Like Tyrosine Kinase‐1 and Placental Growth Factor and Disease Severity Among Women With Preterm Eclampsia and Preeclampsia
title_full_unstemmed Associations Between Soluble fms‐Like Tyrosine Kinase‐1 and Placental Growth Factor and Disease Severity Among Women With Preterm Eclampsia and Preeclampsia
title_short Associations Between Soluble fms‐Like Tyrosine Kinase‐1 and Placental Growth Factor and Disease Severity Among Women With Preterm Eclampsia and Preeclampsia
title_sort associations between soluble fms‐like tyrosine kinase‐1 and placental growth factor and disease severity among women with preterm eclampsia and preeclampsia
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9496300/
https://www.ncbi.nlm.nih.gov/pubmed/35943054
http://dx.doi.org/10.1161/JAHA.121.024395
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