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Lineage Tracing and Molecular Real-Time Imaging of Cancer Stem Cells
The cancer stem cells (CSC) are the roots of cancer. The CSC hypothesis may provide a model to explain the tumor cell heterogeneity. Understand the biological mechanism of CSC will help the early detection and cure of cancer. The discovery of the dynamic changes in CSC will be possible by the using...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9496355/ https://www.ncbi.nlm.nih.gov/pubmed/36140088 http://dx.doi.org/10.3390/bios12090703 |
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author | Jia, Xiaohua Shen, Guodong Jia, Jia Zhang, Yan Zhang, Dan Li, Wanjun Zhang, Jianjun Huang, Xinglu Tian, Jie |
author_facet | Jia, Xiaohua Shen, Guodong Jia, Jia Zhang, Yan Zhang, Dan Li, Wanjun Zhang, Jianjun Huang, Xinglu Tian, Jie |
author_sort | Jia, Xiaohua |
collection | PubMed |
description | The cancer stem cells (CSC) are the roots of cancer. The CSC hypothesis may provide a model to explain the tumor cell heterogeneity. Understand the biological mechanism of CSC will help the early detection and cure of cancer. The discovery of the dynamic changes in CSC will be possible by the using of bio-engineering techniques-lineage tracing. However, it is difficult to obtain real-time, continuous, and dynamic live-imaging information using the traditional approaches that take snapshots of time points from different animals. The goal of molecular imaging is to monitor the in situ, continuous molecular changes of cells in vivo. Therefore, the most advanced bioengineering lineage tracing approach, while using a variety of molecular detection methods, will maximize the presentation of CSC. In this review, we first introduce the method of lineage tracing, and then introduce the various components of molecular images to dynamic detect the CSC. Finally, we analyze the current situation and look forward the future of CSC detection. |
format | Online Article Text |
id | pubmed-9496355 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94963552022-09-23 Lineage Tracing and Molecular Real-Time Imaging of Cancer Stem Cells Jia, Xiaohua Shen, Guodong Jia, Jia Zhang, Yan Zhang, Dan Li, Wanjun Zhang, Jianjun Huang, Xinglu Tian, Jie Biosensors (Basel) Review The cancer stem cells (CSC) are the roots of cancer. The CSC hypothesis may provide a model to explain the tumor cell heterogeneity. Understand the biological mechanism of CSC will help the early detection and cure of cancer. The discovery of the dynamic changes in CSC will be possible by the using of bio-engineering techniques-lineage tracing. However, it is difficult to obtain real-time, continuous, and dynamic live-imaging information using the traditional approaches that take snapshots of time points from different animals. The goal of molecular imaging is to monitor the in situ, continuous molecular changes of cells in vivo. Therefore, the most advanced bioengineering lineage tracing approach, while using a variety of molecular detection methods, will maximize the presentation of CSC. In this review, we first introduce the method of lineage tracing, and then introduce the various components of molecular images to dynamic detect the CSC. Finally, we analyze the current situation and look forward the future of CSC detection. MDPI 2022-09-01 /pmc/articles/PMC9496355/ /pubmed/36140088 http://dx.doi.org/10.3390/bios12090703 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Jia, Xiaohua Shen, Guodong Jia, Jia Zhang, Yan Zhang, Dan Li, Wanjun Zhang, Jianjun Huang, Xinglu Tian, Jie Lineage Tracing and Molecular Real-Time Imaging of Cancer Stem Cells |
title | Lineage Tracing and Molecular Real-Time Imaging of Cancer Stem Cells |
title_full | Lineage Tracing and Molecular Real-Time Imaging of Cancer Stem Cells |
title_fullStr | Lineage Tracing and Molecular Real-Time Imaging of Cancer Stem Cells |
title_full_unstemmed | Lineage Tracing and Molecular Real-Time Imaging of Cancer Stem Cells |
title_short | Lineage Tracing and Molecular Real-Time Imaging of Cancer Stem Cells |
title_sort | lineage tracing and molecular real-time imaging of cancer stem cells |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9496355/ https://www.ncbi.nlm.nih.gov/pubmed/36140088 http://dx.doi.org/10.3390/bios12090703 |
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