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Identification Markers of Carotid Vulnerable Plaques: An Update

Vulnerable plaques have been a hot topic in the field of stroke and carotid atherosclerosis. Currently, risk stratification and intervention of carotid plaques are guided by the degree of luminal stenosis. Recently, it has been recognized that the vulnerability of plaques may contribute to the risk...

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Autores principales: Wang, Yilin, Wang, Tao, Luo, Yumin, Jiao, Liqun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9496377/
https://www.ncbi.nlm.nih.gov/pubmed/36139031
http://dx.doi.org/10.3390/biom12091192
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author Wang, Yilin
Wang, Tao
Luo, Yumin
Jiao, Liqun
author_facet Wang, Yilin
Wang, Tao
Luo, Yumin
Jiao, Liqun
author_sort Wang, Yilin
collection PubMed
description Vulnerable plaques have been a hot topic in the field of stroke and carotid atherosclerosis. Currently, risk stratification and intervention of carotid plaques are guided by the degree of luminal stenosis. Recently, it has been recognized that the vulnerability of plaques may contribute to the risk of stroke. Some classical interventions, such as carotid endarterectomy, significantly reduce the risk of stroke in symptomatic patients with severe carotid stenosis, while for asymptomatic patients, clinically silent plaques with rupture tendency may expose them to the risk of cerebrovascular events. Early identification of vulnerable plaques contributes to lowering the risk of cerebrovascular events. Previously, the identification of vulnerable plaques was commonly based on imaging technologies at the macroscopic level. Recently, some microscopic molecules pertaining to vulnerable plaques have emerged, and could be potential biomarkers or therapeutic targets. This review aimed to update the previous summarization of vulnerable plaques and identify vulnerable plaques at the microscopic and macroscopic levels.
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spelling pubmed-94963772022-09-23 Identification Markers of Carotid Vulnerable Plaques: An Update Wang, Yilin Wang, Tao Luo, Yumin Jiao, Liqun Biomolecules Review Vulnerable plaques have been a hot topic in the field of stroke and carotid atherosclerosis. Currently, risk stratification and intervention of carotid plaques are guided by the degree of luminal stenosis. Recently, it has been recognized that the vulnerability of plaques may contribute to the risk of stroke. Some classical interventions, such as carotid endarterectomy, significantly reduce the risk of stroke in symptomatic patients with severe carotid stenosis, while for asymptomatic patients, clinically silent plaques with rupture tendency may expose them to the risk of cerebrovascular events. Early identification of vulnerable plaques contributes to lowering the risk of cerebrovascular events. Previously, the identification of vulnerable plaques was commonly based on imaging technologies at the macroscopic level. Recently, some microscopic molecules pertaining to vulnerable plaques have emerged, and could be potential biomarkers or therapeutic targets. This review aimed to update the previous summarization of vulnerable plaques and identify vulnerable plaques at the microscopic and macroscopic levels. MDPI 2022-08-28 /pmc/articles/PMC9496377/ /pubmed/36139031 http://dx.doi.org/10.3390/biom12091192 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Wang, Yilin
Wang, Tao
Luo, Yumin
Jiao, Liqun
Identification Markers of Carotid Vulnerable Plaques: An Update
title Identification Markers of Carotid Vulnerable Plaques: An Update
title_full Identification Markers of Carotid Vulnerable Plaques: An Update
title_fullStr Identification Markers of Carotid Vulnerable Plaques: An Update
title_full_unstemmed Identification Markers of Carotid Vulnerable Plaques: An Update
title_short Identification Markers of Carotid Vulnerable Plaques: An Update
title_sort identification markers of carotid vulnerable plaques: an update
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9496377/
https://www.ncbi.nlm.nih.gov/pubmed/36139031
http://dx.doi.org/10.3390/biom12091192
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