Rational Generation of Monoclonal Antibodies Selective for Pathogenic Forms of Alpha-Synuclein

Misfolded toxic forms of alpha-synuclein (α-Syn) have been implicated in the pathogenesis of synucleinopathies, including Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA). The α-Syn oligomers and soluble fibrils have been shown to mediate neurotoxicity and...

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Detalles Bibliográficos
Autores principales: Gibbs, Ebrima, Zhao, Beibei, Roman, Andrei, Plotkin, Steven S., Peng, Xubiao, Hsueh, Shawn C. C., Aina, Adekunle, Wang, Jing, Shyu, Clay, Yip, Calvin K., Nam, Sung-Eun, Kaplan, Johanne M., Cashman, Neil R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9496384/
https://www.ncbi.nlm.nih.gov/pubmed/36140270
http://dx.doi.org/10.3390/biomedicines10092168

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