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Optofluidic Particle Manipulation: Optical Trapping in a Thin-Membrane Microchannel

We demonstrate an optofluidic device which utilizes the optical scattering and gradient forces for particle trapping in microchannels featuring 300 nm thick membranes. On-chip waveguides are used to direct light into microfluidic trapping channels. Radiation pressure is used to push particles into a...

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Autores principales: Walker, Zachary J., Wells, Tanner, Belliston, Ethan, Walker, Seth B., Zeller, Carson, Sampad, Mohammad Julker Neyen, Saiduzzaman, S. M., Schmidt, Holger, Hawkins, Aaron R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9496393/
https://www.ncbi.nlm.nih.gov/pubmed/36140075
http://dx.doi.org/10.3390/bios12090690
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author Walker, Zachary J.
Wells, Tanner
Belliston, Ethan
Walker, Seth B.
Zeller, Carson
Sampad, Mohammad Julker Neyen
Saiduzzaman, S. M.
Schmidt, Holger
Hawkins, Aaron R.
author_facet Walker, Zachary J.
Wells, Tanner
Belliston, Ethan
Walker, Seth B.
Zeller, Carson
Sampad, Mohammad Julker Neyen
Saiduzzaman, S. M.
Schmidt, Holger
Hawkins, Aaron R.
author_sort Walker, Zachary J.
collection PubMed
description We demonstrate an optofluidic device which utilizes the optical scattering and gradient forces for particle trapping in microchannels featuring 300 nm thick membranes. On-chip waveguides are used to direct light into microfluidic trapping channels. Radiation pressure is used to push particles into a protrusion cavity, isolating the particles from liquid flow. Two different designs are presented: the first exclusively uses the optical scattering force for particle manipulation, and the second uses both scattering and gradient forces. Trapping performance is modeled for both cases. The first design, referred to as the orthogonal force design, is shown to have a 80% capture efficiency under typical operating conditions. The second design, referred to as the gradient force design, is shown to have 98% efficiency under the same conditions.
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spelling pubmed-94963932022-09-23 Optofluidic Particle Manipulation: Optical Trapping in a Thin-Membrane Microchannel Walker, Zachary J. Wells, Tanner Belliston, Ethan Walker, Seth B. Zeller, Carson Sampad, Mohammad Julker Neyen Saiduzzaman, S. M. Schmidt, Holger Hawkins, Aaron R. Biosensors (Basel) Article We demonstrate an optofluidic device which utilizes the optical scattering and gradient forces for particle trapping in microchannels featuring 300 nm thick membranes. On-chip waveguides are used to direct light into microfluidic trapping channels. Radiation pressure is used to push particles into a protrusion cavity, isolating the particles from liquid flow. Two different designs are presented: the first exclusively uses the optical scattering force for particle manipulation, and the second uses both scattering and gradient forces. Trapping performance is modeled for both cases. The first design, referred to as the orthogonal force design, is shown to have a 80% capture efficiency under typical operating conditions. The second design, referred to as the gradient force design, is shown to have 98% efficiency under the same conditions. MDPI 2022-08-27 /pmc/articles/PMC9496393/ /pubmed/36140075 http://dx.doi.org/10.3390/bios12090690 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Walker, Zachary J.
Wells, Tanner
Belliston, Ethan
Walker, Seth B.
Zeller, Carson
Sampad, Mohammad Julker Neyen
Saiduzzaman, S. M.
Schmidt, Holger
Hawkins, Aaron R.
Optofluidic Particle Manipulation: Optical Trapping in a Thin-Membrane Microchannel
title Optofluidic Particle Manipulation: Optical Trapping in a Thin-Membrane Microchannel
title_full Optofluidic Particle Manipulation: Optical Trapping in a Thin-Membrane Microchannel
title_fullStr Optofluidic Particle Manipulation: Optical Trapping in a Thin-Membrane Microchannel
title_full_unstemmed Optofluidic Particle Manipulation: Optical Trapping in a Thin-Membrane Microchannel
title_short Optofluidic Particle Manipulation: Optical Trapping in a Thin-Membrane Microchannel
title_sort optofluidic particle manipulation: optical trapping in a thin-membrane microchannel
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9496393/
https://www.ncbi.nlm.nih.gov/pubmed/36140075
http://dx.doi.org/10.3390/bios12090690
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