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Optofluidic Particle Manipulation: Optical Trapping in a Thin-Membrane Microchannel
We demonstrate an optofluidic device which utilizes the optical scattering and gradient forces for particle trapping in microchannels featuring 300 nm thick membranes. On-chip waveguides are used to direct light into microfluidic trapping channels. Radiation pressure is used to push particles into a...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9496393/ https://www.ncbi.nlm.nih.gov/pubmed/36140075 http://dx.doi.org/10.3390/bios12090690 |
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author | Walker, Zachary J. Wells, Tanner Belliston, Ethan Walker, Seth B. Zeller, Carson Sampad, Mohammad Julker Neyen Saiduzzaman, S. M. Schmidt, Holger Hawkins, Aaron R. |
author_facet | Walker, Zachary J. Wells, Tanner Belliston, Ethan Walker, Seth B. Zeller, Carson Sampad, Mohammad Julker Neyen Saiduzzaman, S. M. Schmidt, Holger Hawkins, Aaron R. |
author_sort | Walker, Zachary J. |
collection | PubMed |
description | We demonstrate an optofluidic device which utilizes the optical scattering and gradient forces for particle trapping in microchannels featuring 300 nm thick membranes. On-chip waveguides are used to direct light into microfluidic trapping channels. Radiation pressure is used to push particles into a protrusion cavity, isolating the particles from liquid flow. Two different designs are presented: the first exclusively uses the optical scattering force for particle manipulation, and the second uses both scattering and gradient forces. Trapping performance is modeled for both cases. The first design, referred to as the orthogonal force design, is shown to have a 80% capture efficiency under typical operating conditions. The second design, referred to as the gradient force design, is shown to have 98% efficiency under the same conditions. |
format | Online Article Text |
id | pubmed-9496393 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94963932022-09-23 Optofluidic Particle Manipulation: Optical Trapping in a Thin-Membrane Microchannel Walker, Zachary J. Wells, Tanner Belliston, Ethan Walker, Seth B. Zeller, Carson Sampad, Mohammad Julker Neyen Saiduzzaman, S. M. Schmidt, Holger Hawkins, Aaron R. Biosensors (Basel) Article We demonstrate an optofluidic device which utilizes the optical scattering and gradient forces for particle trapping in microchannels featuring 300 nm thick membranes. On-chip waveguides are used to direct light into microfluidic trapping channels. Radiation pressure is used to push particles into a protrusion cavity, isolating the particles from liquid flow. Two different designs are presented: the first exclusively uses the optical scattering force for particle manipulation, and the second uses both scattering and gradient forces. Trapping performance is modeled for both cases. The first design, referred to as the orthogonal force design, is shown to have a 80% capture efficiency under typical operating conditions. The second design, referred to as the gradient force design, is shown to have 98% efficiency under the same conditions. MDPI 2022-08-27 /pmc/articles/PMC9496393/ /pubmed/36140075 http://dx.doi.org/10.3390/bios12090690 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Walker, Zachary J. Wells, Tanner Belliston, Ethan Walker, Seth B. Zeller, Carson Sampad, Mohammad Julker Neyen Saiduzzaman, S. M. Schmidt, Holger Hawkins, Aaron R. Optofluidic Particle Manipulation: Optical Trapping in a Thin-Membrane Microchannel |
title | Optofluidic Particle Manipulation: Optical Trapping in a Thin-Membrane Microchannel |
title_full | Optofluidic Particle Manipulation: Optical Trapping in a Thin-Membrane Microchannel |
title_fullStr | Optofluidic Particle Manipulation: Optical Trapping in a Thin-Membrane Microchannel |
title_full_unstemmed | Optofluidic Particle Manipulation: Optical Trapping in a Thin-Membrane Microchannel |
title_short | Optofluidic Particle Manipulation: Optical Trapping in a Thin-Membrane Microchannel |
title_sort | optofluidic particle manipulation: optical trapping in a thin-membrane microchannel |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9496393/ https://www.ncbi.nlm.nih.gov/pubmed/36140075 http://dx.doi.org/10.3390/bios12090690 |
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