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Diagnosis of Malnutrition According to GLIM Criteria Predicts Complications and 6-Month Survival in Cancer Outpatients

Background and Aims: Malnutrition is a condition that has a great impact on oncology patients. Poor nutritional status is often associated with increased morbidity and mortality, increased toxicity, and reduced tolerance to chemotherapy, among other complications. The recently developed GLIM criteri...

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Autores principales: Gascón-Ruiz, Marta, Casas-Deza, Diego, Marti-Pi, Maria, Torres-Ramón, Irene, Zapata-García, María, Sesma, Andrea, Lambea, Julio, Álvarez-Alejandro, María, Quilez, Elisa, Isla, Dolores, Arbonés-Mainar, Jose Miguel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9496397/
https://www.ncbi.nlm.nih.gov/pubmed/36140301
http://dx.doi.org/10.3390/biomedicines10092201
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author Gascón-Ruiz, Marta
Casas-Deza, Diego
Marti-Pi, Maria
Torres-Ramón, Irene
Zapata-García, María
Sesma, Andrea
Lambea, Julio
Álvarez-Alejandro, María
Quilez, Elisa
Isla, Dolores
Arbonés-Mainar, Jose Miguel
author_facet Gascón-Ruiz, Marta
Casas-Deza, Diego
Marti-Pi, Maria
Torres-Ramón, Irene
Zapata-García, María
Sesma, Andrea
Lambea, Julio
Álvarez-Alejandro, María
Quilez, Elisa
Isla, Dolores
Arbonés-Mainar, Jose Miguel
author_sort Gascón-Ruiz, Marta
collection PubMed
description Background and Aims: Malnutrition is a condition that has a great impact on oncology patients. Poor nutritional status is often associated with increased morbidity and mortality, increased toxicity, and reduced tolerance to chemotherapy, among other complications. The recently developed GLIM criteria for malnutrition aim to homogenize its diagnosis, considering the baseline disease status. We aimed to evaluate the performance of these new criteria for the prediction of complications and mortality in patients with cancer. Methods: This work is a prospective, single-center study. All outpatients under active treatment for head and neck, upper gastrointestinal, and colorectal tumors between February and October 2020 were recruited. These patients were followed up for 6 months, assessing the occurrence of complications and survival based on GLIM diagnoses of malnutrition. Results: We enrolled 165 outpatients, 46.66% of whom were malnourished. During the 6-month follow-ups, patients with malnutrition (46.7%, according to GLIM criteria) had a ~3-fold increased risk of hospital admission (p < 0.001) and occurrence of severe infection (considered as those requiring hospitalization, intravenous antibiotics, and/or drainage by interventional procedures) (p = 0.002). Similarly, malnourished patients had a 3.5-fold increased risk of poor pain control and a 4.4-fold increased need for higher doses of opioids (both p < 0.001). They also had a 2.6-fold increased risk of toxicity (p = 0.044) and a 2.5-fold increased likelihood of needing a dose decrease or discontinuation of cancer treatment (p = 0.011). The 6-month survival of malnourished patients was significantly lower (p = 0.023) than in non-malnourished patients. Conclusions: Diagnoses of malnutrition according to the GLIM criteria in oncology patients undergoing active treatment predict increased complications and worse survival at 6-month follow-ups, making them a useful tool for assessing the nutritional status of oncology patients.
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spelling pubmed-94963972022-09-23 Diagnosis of Malnutrition According to GLIM Criteria Predicts Complications and 6-Month Survival in Cancer Outpatients Gascón-Ruiz, Marta Casas-Deza, Diego Marti-Pi, Maria Torres-Ramón, Irene Zapata-García, María Sesma, Andrea Lambea, Julio Álvarez-Alejandro, María Quilez, Elisa Isla, Dolores Arbonés-Mainar, Jose Miguel Biomedicines Article Background and Aims: Malnutrition is a condition that has a great impact on oncology patients. Poor nutritional status is often associated with increased morbidity and mortality, increased toxicity, and reduced tolerance to chemotherapy, among other complications. The recently developed GLIM criteria for malnutrition aim to homogenize its diagnosis, considering the baseline disease status. We aimed to evaluate the performance of these new criteria for the prediction of complications and mortality in patients with cancer. Methods: This work is a prospective, single-center study. All outpatients under active treatment for head and neck, upper gastrointestinal, and colorectal tumors between February and October 2020 were recruited. These patients were followed up for 6 months, assessing the occurrence of complications and survival based on GLIM diagnoses of malnutrition. Results: We enrolled 165 outpatients, 46.66% of whom were malnourished. During the 6-month follow-ups, patients with malnutrition (46.7%, according to GLIM criteria) had a ~3-fold increased risk of hospital admission (p < 0.001) and occurrence of severe infection (considered as those requiring hospitalization, intravenous antibiotics, and/or drainage by interventional procedures) (p = 0.002). Similarly, malnourished patients had a 3.5-fold increased risk of poor pain control and a 4.4-fold increased need for higher doses of opioids (both p < 0.001). They also had a 2.6-fold increased risk of toxicity (p = 0.044) and a 2.5-fold increased likelihood of needing a dose decrease or discontinuation of cancer treatment (p = 0.011). The 6-month survival of malnourished patients was significantly lower (p = 0.023) than in non-malnourished patients. Conclusions: Diagnoses of malnutrition according to the GLIM criteria in oncology patients undergoing active treatment predict increased complications and worse survival at 6-month follow-ups, making them a useful tool for assessing the nutritional status of oncology patients. MDPI 2022-09-06 /pmc/articles/PMC9496397/ /pubmed/36140301 http://dx.doi.org/10.3390/biomedicines10092201 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gascón-Ruiz, Marta
Casas-Deza, Diego
Marti-Pi, Maria
Torres-Ramón, Irene
Zapata-García, María
Sesma, Andrea
Lambea, Julio
Álvarez-Alejandro, María
Quilez, Elisa
Isla, Dolores
Arbonés-Mainar, Jose Miguel
Diagnosis of Malnutrition According to GLIM Criteria Predicts Complications and 6-Month Survival in Cancer Outpatients
title Diagnosis of Malnutrition According to GLIM Criteria Predicts Complications and 6-Month Survival in Cancer Outpatients
title_full Diagnosis of Malnutrition According to GLIM Criteria Predicts Complications and 6-Month Survival in Cancer Outpatients
title_fullStr Diagnosis of Malnutrition According to GLIM Criteria Predicts Complications and 6-Month Survival in Cancer Outpatients
title_full_unstemmed Diagnosis of Malnutrition According to GLIM Criteria Predicts Complications and 6-Month Survival in Cancer Outpatients
title_short Diagnosis of Malnutrition According to GLIM Criteria Predicts Complications and 6-Month Survival in Cancer Outpatients
title_sort diagnosis of malnutrition according to glim criteria predicts complications and 6-month survival in cancer outpatients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9496397/
https://www.ncbi.nlm.nih.gov/pubmed/36140301
http://dx.doi.org/10.3390/biomedicines10092201
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