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Stroke–Heart Syndrome: Recent Advances and Challenges
After ischemic stroke, there is a significant burden of cardiovascular complications, both in the acute and chronic phase. Severe adverse cardiac events occur in 10% to 20% of patients within the first few days after stroke and comprise a continuum of cardiac changes ranging from acute myocardial in...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9496419/ https://www.ncbi.nlm.nih.gov/pubmed/36056731 http://dx.doi.org/10.1161/JAHA.122.026528 |
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author | Scheitz, Jan F. Sposato, Luciano A. Schulz‐Menger, Jeanette Nolte, Christian H. Backs, Johannes Endres, Matthias |
author_facet | Scheitz, Jan F. Sposato, Luciano A. Schulz‐Menger, Jeanette Nolte, Christian H. Backs, Johannes Endres, Matthias |
author_sort | Scheitz, Jan F. |
collection | PubMed |
description | After ischemic stroke, there is a significant burden of cardiovascular complications, both in the acute and chronic phase. Severe adverse cardiac events occur in 10% to 20% of patients within the first few days after stroke and comprise a continuum of cardiac changes ranging from acute myocardial injury and coronary syndromes to heart failure or arrhythmia. Recently, the term stroke–heart syndrome was introduced to provide an integrated conceptual framework that summarizes neurocardiogenic mechanisms that lead to these cardiac events after stroke. New findings from experimental and clinical studies have further refined our understanding of the clinical manifestations, pathophysiology, and potential long‐term consequences of the stroke–heart syndrome. Local cerebral and systemic mediators, which mainly involve autonomic dysfunction and increased inflammation, may lead to altered cardiomyocyte metabolism, dysregulation of (tissue‐resident) leukocyte populations, and (micro‐) vascular changes. However, at the individual patient level, it remains challenging to differentiate between comorbid cardiovascular conditions and stroke‐induced heart injury. Therefore, further research activities led by joint teams of basic and clinical researchers with backgrounds in both cardiology and neurology are needed to identify the most relevant therapeutic targets that can be tested in clinical trials. |
format | Online Article Text |
id | pubmed-9496419 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-94964192022-09-30 Stroke–Heart Syndrome: Recent Advances and Challenges Scheitz, Jan F. Sposato, Luciano A. Schulz‐Menger, Jeanette Nolte, Christian H. Backs, Johannes Endres, Matthias J Am Heart Assoc Contemporary Review After ischemic stroke, there is a significant burden of cardiovascular complications, both in the acute and chronic phase. Severe adverse cardiac events occur in 10% to 20% of patients within the first few days after stroke and comprise a continuum of cardiac changes ranging from acute myocardial injury and coronary syndromes to heart failure or arrhythmia. Recently, the term stroke–heart syndrome was introduced to provide an integrated conceptual framework that summarizes neurocardiogenic mechanisms that lead to these cardiac events after stroke. New findings from experimental and clinical studies have further refined our understanding of the clinical manifestations, pathophysiology, and potential long‐term consequences of the stroke–heart syndrome. Local cerebral and systemic mediators, which mainly involve autonomic dysfunction and increased inflammation, may lead to altered cardiomyocyte metabolism, dysregulation of (tissue‐resident) leukocyte populations, and (micro‐) vascular changes. However, at the individual patient level, it remains challenging to differentiate between comorbid cardiovascular conditions and stroke‐induced heart injury. Therefore, further research activities led by joint teams of basic and clinical researchers with backgrounds in both cardiology and neurology are needed to identify the most relevant therapeutic targets that can be tested in clinical trials. John Wiley and Sons Inc. 2022-09-03 /pmc/articles/PMC9496419/ /pubmed/36056731 http://dx.doi.org/10.1161/JAHA.122.026528 Text en © 2022 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Contemporary Review Scheitz, Jan F. Sposato, Luciano A. Schulz‐Menger, Jeanette Nolte, Christian H. Backs, Johannes Endres, Matthias Stroke–Heart Syndrome: Recent Advances and Challenges |
title | Stroke–Heart Syndrome: Recent Advances and Challenges |
title_full | Stroke–Heart Syndrome: Recent Advances and Challenges |
title_fullStr | Stroke–Heart Syndrome: Recent Advances and Challenges |
title_full_unstemmed | Stroke–Heart Syndrome: Recent Advances and Challenges |
title_short | Stroke–Heart Syndrome: Recent Advances and Challenges |
title_sort | stroke–heart syndrome: recent advances and challenges |
topic | Contemporary Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9496419/ https://www.ncbi.nlm.nih.gov/pubmed/36056731 http://dx.doi.org/10.1161/JAHA.122.026528 |
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