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A Comprehensive Review on Collagen Type I Development of Biomaterials for Tissue Engineering: From Biosynthesis to Bioscaffold

Collagen is the most abundant structural protein found in humans and mammals, particularly in the extracellular matrix (ECM). Its primary function is to hold the body together. The collagen superfamily of proteins includes over 20 types that have been identified. Yet, collagen type I is the major co...

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Autores principales: Amirrah, Ibrahim N., Lokanathan, Yogeswaran, Zulkiflee, Izzat, Wee, M. F. Mohd Razip, Motta, Antonella, Fauzi, Mh Busra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9496548/
https://www.ncbi.nlm.nih.gov/pubmed/36140407
http://dx.doi.org/10.3390/biomedicines10092307
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author Amirrah, Ibrahim N.
Lokanathan, Yogeswaran
Zulkiflee, Izzat
Wee, M. F. Mohd Razip
Motta, Antonella
Fauzi, Mh Busra
author_facet Amirrah, Ibrahim N.
Lokanathan, Yogeswaran
Zulkiflee, Izzat
Wee, M. F. Mohd Razip
Motta, Antonella
Fauzi, Mh Busra
author_sort Amirrah, Ibrahim N.
collection PubMed
description Collagen is the most abundant structural protein found in humans and mammals, particularly in the extracellular matrix (ECM). Its primary function is to hold the body together. The collagen superfamily of proteins includes over 20 types that have been identified. Yet, collagen type I is the major component in many tissues and can be extracted as a natural biomaterial for various medical and biological purposes. Collagen has multiple advantageous characteristics, including varied sources, biocompatibility, sustainability, low immunogenicity, porosity, and biodegradability. As such, collagen-type-I-based bioscaffolds have been widely used in tissue engineering. Biomaterials based on collagen type I can also be modified to improve their functions, such as by crosslinking to strengthen the mechanical property or adding biochemical factors to enhance their biological activity. This review discusses the complexities of collagen type I structure, biosynthesis, sources for collagen derivatives, methods of isolation and purification, physicochemical characteristics, and the current development of collagen-type-I-based scaffolds in tissue engineering applications. The advancement of additional novel tissue engineered bioproducts with refined techniques and continuous biomaterial augmentation is facilitated by understanding the conventional design and application of biomaterials based on collagen type I.
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spelling pubmed-94965482022-09-23 A Comprehensive Review on Collagen Type I Development of Biomaterials for Tissue Engineering: From Biosynthesis to Bioscaffold Amirrah, Ibrahim N. Lokanathan, Yogeswaran Zulkiflee, Izzat Wee, M. F. Mohd Razip Motta, Antonella Fauzi, Mh Busra Biomedicines Review Collagen is the most abundant structural protein found in humans and mammals, particularly in the extracellular matrix (ECM). Its primary function is to hold the body together. The collagen superfamily of proteins includes over 20 types that have been identified. Yet, collagen type I is the major component in many tissues and can be extracted as a natural biomaterial for various medical and biological purposes. Collagen has multiple advantageous characteristics, including varied sources, biocompatibility, sustainability, low immunogenicity, porosity, and biodegradability. As such, collagen-type-I-based bioscaffolds have been widely used in tissue engineering. Biomaterials based on collagen type I can also be modified to improve their functions, such as by crosslinking to strengthen the mechanical property or adding biochemical factors to enhance their biological activity. This review discusses the complexities of collagen type I structure, biosynthesis, sources for collagen derivatives, methods of isolation and purification, physicochemical characteristics, and the current development of collagen-type-I-based scaffolds in tissue engineering applications. The advancement of additional novel tissue engineered bioproducts with refined techniques and continuous biomaterial augmentation is facilitated by understanding the conventional design and application of biomaterials based on collagen type I. MDPI 2022-09-16 /pmc/articles/PMC9496548/ /pubmed/36140407 http://dx.doi.org/10.3390/biomedicines10092307 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Amirrah, Ibrahim N.
Lokanathan, Yogeswaran
Zulkiflee, Izzat
Wee, M. F. Mohd Razip
Motta, Antonella
Fauzi, Mh Busra
A Comprehensive Review on Collagen Type I Development of Biomaterials for Tissue Engineering: From Biosynthesis to Bioscaffold
title A Comprehensive Review on Collagen Type I Development of Biomaterials for Tissue Engineering: From Biosynthesis to Bioscaffold
title_full A Comprehensive Review on Collagen Type I Development of Biomaterials for Tissue Engineering: From Biosynthesis to Bioscaffold
title_fullStr A Comprehensive Review on Collagen Type I Development of Biomaterials for Tissue Engineering: From Biosynthesis to Bioscaffold
title_full_unstemmed A Comprehensive Review on Collagen Type I Development of Biomaterials for Tissue Engineering: From Biosynthesis to Bioscaffold
title_short A Comprehensive Review on Collagen Type I Development of Biomaterials for Tissue Engineering: From Biosynthesis to Bioscaffold
title_sort comprehensive review on collagen type i development of biomaterials for tissue engineering: from biosynthesis to bioscaffold
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9496548/
https://www.ncbi.nlm.nih.gov/pubmed/36140407
http://dx.doi.org/10.3390/biomedicines10092307
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