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Detection of 3,4-Methylene Dioxy Amphetamine in Urine by Magnetically Improved Surface-Enhanced Raman Scattering Sensing Strategy

Abuse of illicit drugs has become a major issue of global concern. As a synthetic amphetamine analog, 3,4-Methylene Dioxy Amphetamine (MDA) causes serotonergic neurotoxicity, posing a serious risk to human health. In this work, a two-dimensional substrate of ITO/Au is fabricated by transferring Au n...

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Autores principales: Wang, Yue, Teng, Xinyan, Cao, Jiaying, Fan, Yilei, Liu, Xinling, Guo, Xiaoyu, Xu, Yu, Wen, Ying, Yang, Haifeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9496583/
https://www.ncbi.nlm.nih.gov/pubmed/36140096
http://dx.doi.org/10.3390/bios12090711
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author Wang, Yue
Teng, Xinyan
Cao, Jiaying
Fan, Yilei
Liu, Xinling
Guo, Xiaoyu
Xu, Yu
Wen, Ying
Yang, Haifeng
author_facet Wang, Yue
Teng, Xinyan
Cao, Jiaying
Fan, Yilei
Liu, Xinling
Guo, Xiaoyu
Xu, Yu
Wen, Ying
Yang, Haifeng
author_sort Wang, Yue
collection PubMed
description Abuse of illicit drugs has become a major issue of global concern. As a synthetic amphetamine analog, 3,4-Methylene Dioxy Amphetamine (MDA) causes serotonergic neurotoxicity, posing a serious risk to human health. In this work, a two-dimensional substrate of ITO/Au is fabricated by transferring Au nanoparticle film onto indium–tin oxide glass (ITO). By magnetic inducing assembly of Fe(3)O(4)@Au onto ITO/Au, a sandwich-based, surface-enhanced Raman scattering (SERS) detection strategy is designed. Through the use of an external magnet, the MDA is retained in the region of hot spots formed between Fe(3)O(4)@Au and ITO/Au; as a result, the SERS sensitivity for MDA is superior compared to other methods, lowering the limit of detection (LOD) to 0.0685 ng/mL and attaining a corresponding linear dynamic detection range of 5–10(5) ng/mL. As an actual application, this magnetically improved SERS sensing strategy is successfully applied to distinguish MDA in urine at trace level, which is beneficial to clinical and forensic monitors.
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spelling pubmed-94965832022-09-23 Detection of 3,4-Methylene Dioxy Amphetamine in Urine by Magnetically Improved Surface-Enhanced Raman Scattering Sensing Strategy Wang, Yue Teng, Xinyan Cao, Jiaying Fan, Yilei Liu, Xinling Guo, Xiaoyu Xu, Yu Wen, Ying Yang, Haifeng Biosensors (Basel) Communication Abuse of illicit drugs has become a major issue of global concern. As a synthetic amphetamine analog, 3,4-Methylene Dioxy Amphetamine (MDA) causes serotonergic neurotoxicity, posing a serious risk to human health. In this work, a two-dimensional substrate of ITO/Au is fabricated by transferring Au nanoparticle film onto indium–tin oxide glass (ITO). By magnetic inducing assembly of Fe(3)O(4)@Au onto ITO/Au, a sandwich-based, surface-enhanced Raman scattering (SERS) detection strategy is designed. Through the use of an external magnet, the MDA is retained in the region of hot spots formed between Fe(3)O(4)@Au and ITO/Au; as a result, the SERS sensitivity for MDA is superior compared to other methods, lowering the limit of detection (LOD) to 0.0685 ng/mL and attaining a corresponding linear dynamic detection range of 5–10(5) ng/mL. As an actual application, this magnetically improved SERS sensing strategy is successfully applied to distinguish MDA in urine at trace level, which is beneficial to clinical and forensic monitors. MDPI 2022-09-02 /pmc/articles/PMC9496583/ /pubmed/36140096 http://dx.doi.org/10.3390/bios12090711 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Wang, Yue
Teng, Xinyan
Cao, Jiaying
Fan, Yilei
Liu, Xinling
Guo, Xiaoyu
Xu, Yu
Wen, Ying
Yang, Haifeng
Detection of 3,4-Methylene Dioxy Amphetamine in Urine by Magnetically Improved Surface-Enhanced Raman Scattering Sensing Strategy
title Detection of 3,4-Methylene Dioxy Amphetamine in Urine by Magnetically Improved Surface-Enhanced Raman Scattering Sensing Strategy
title_full Detection of 3,4-Methylene Dioxy Amphetamine in Urine by Magnetically Improved Surface-Enhanced Raman Scattering Sensing Strategy
title_fullStr Detection of 3,4-Methylene Dioxy Amphetamine in Urine by Magnetically Improved Surface-Enhanced Raman Scattering Sensing Strategy
title_full_unstemmed Detection of 3,4-Methylene Dioxy Amphetamine in Urine by Magnetically Improved Surface-Enhanced Raman Scattering Sensing Strategy
title_short Detection of 3,4-Methylene Dioxy Amphetamine in Urine by Magnetically Improved Surface-Enhanced Raman Scattering Sensing Strategy
title_sort detection of 3,4-methylene dioxy amphetamine in urine by magnetically improved surface-enhanced raman scattering sensing strategy
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9496583/
https://www.ncbi.nlm.nih.gov/pubmed/36140096
http://dx.doi.org/10.3390/bios12090711
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