Optic Nerve Glioma in Neurofibromatosis: Radiological Clues to Diagnosis in a Young Child

A 13-month-old boy presented with delay in attainment of milestones. On examination, he had café au lait spots and central hypotonia. MRI brain with contrast revealed bilateral bulky enhancing optic nerves with involvement of chiasma. Mid-orbit downward kinking and pseudo-cerebrospinal fluid sign cl...

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Autores principales: Patel, Harsh, Chakrabarty, Biswaroop, Dubey, Rachna, Kumar, Atin, Gulati, Sheffali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2021
Materias:
Neuroimaging
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9496607/
https://www.ncbi.nlm.nih.gov/pubmed/36160611
http://dx.doi.org/10.4103/jpn.JPN_189_20
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author Patel, Harsh
Chakrabarty, Biswaroop
Dubey, Rachna
Kumar, Atin
Gulati, Sheffali
author_facet Patel, Harsh
Chakrabarty, Biswaroop
Dubey, Rachna
Kumar, Atin
Gulati, Sheffali
author_sort Patel, Harsh
collection PubMed
description A 13-month-old boy presented with delay in attainment of milestones. On examination, he had café au lait spots and central hypotonia. MRI brain with contrast revealed bilateral bulky enhancing optic nerves with involvement of chiasma. Mid-orbit downward kinking and pseudo-cerebrospinal fluid sign classical of optic nerve glioma (OPG) with neurofibromatosis1 (NF1) could be well appreciated in the MRI. Correct identification of OPG may help in the diagnosis of NF1 in a young child, as other phenotypic features appear later in childhood.
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spelling pubmed-94966072022-09-23 Optic Nerve Glioma in Neurofibromatosis: Radiological Clues to Diagnosis in a Young Child Patel, Harsh Chakrabarty, Biswaroop Dubey, Rachna Kumar, Atin Gulati, Sheffali J Pediatr Neurosci Neuroimaging A 13-month-old boy presented with delay in attainment of milestones. On examination, he had café au lait spots and central hypotonia. MRI brain with contrast revealed bilateral bulky enhancing optic nerves with involvement of chiasma. Mid-orbit downward kinking and pseudo-cerebrospinal fluid sign classical of optic nerve glioma (OPG) with neurofibromatosis1 (NF1) could be well appreciated in the MRI. Correct identification of OPG may help in the diagnosis of NF1 in a young child, as other phenotypic features appear later in childhood. Wolters Kluwer - Medknow 2021 2021-07-12 /pmc/articles/PMC9496607/ /pubmed/36160611 http://dx.doi.org/10.4103/jpn.JPN_189_20 Text en Copyright: © 2021 Journal of Pediatric Neurosciences https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Neuroimaging
Patel, Harsh
Chakrabarty, Biswaroop
Dubey, Rachna
Kumar, Atin
Gulati, Sheffali
Optic Nerve Glioma in Neurofibromatosis: Radiological Clues to Diagnosis in a Young Child
title Optic Nerve Glioma in Neurofibromatosis: Radiological Clues to Diagnosis in a Young Child
title_full Optic Nerve Glioma in Neurofibromatosis: Radiological Clues to Diagnosis in a Young Child
title_fullStr Optic Nerve Glioma in Neurofibromatosis: Radiological Clues to Diagnosis in a Young Child
title_full_unstemmed Optic Nerve Glioma in Neurofibromatosis: Radiological Clues to Diagnosis in a Young Child
title_short Optic Nerve Glioma in Neurofibromatosis: Radiological Clues to Diagnosis in a Young Child
title_sort optic nerve glioma in neurofibromatosis: radiological clues to diagnosis in a young child
topic Neuroimaging
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9496607/
https://www.ncbi.nlm.nih.gov/pubmed/36160611
http://dx.doi.org/10.4103/jpn.JPN_189_20
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AT chakrabartybiswaroop opticnervegliomainneurofibromatosisradiologicalcluestodiagnosisinayoungchild
AT dubeyrachna opticnervegliomainneurofibromatosisradiologicalcluestodiagnosisinayoungchild
AT kumaratin opticnervegliomainneurofibromatosisradiologicalcluestodiagnosisinayoungchild
AT gulatisheffali opticnervegliomainneurofibromatosisradiologicalcluestodiagnosisinayoungchild

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