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Elucidating the Neurobiologic Etiology of Comorbid PTSD and Substance Use Disorders

Early childhood maltreatment and other traumatic event experiences (“trauma”) are common among youth, including those with substance use problems including substance use disorders (SUD). Particularly, interpersonal violence is associated with high rates of comorbidity between posttraumatic stress di...

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Detalles Bibliográficos
Autores principales: Hinckley, Jesse D., Danielson, Carla Kmett
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9496654/
https://www.ncbi.nlm.nih.gov/pubmed/36138902
http://dx.doi.org/10.3390/brainsci12091166
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author Hinckley, Jesse D.
Danielson, Carla Kmett
author_facet Hinckley, Jesse D.
Danielson, Carla Kmett
author_sort Hinckley, Jesse D.
collection PubMed
description Early childhood maltreatment and other traumatic event experiences (“trauma”) are common among youth, including those with substance use problems including substance use disorders (SUD). Particularly, interpersonal violence is associated with high rates of comorbidity between posttraumatic stress disorder (PTSD) and SUD, and these comorbid disorders exhibit high levels of overlapping symptomatology. Theoretical models proposed to explain the bidirectional relationship between PTSD and SUD include the self-medication hypothesis and susceptibility hypothesis. In this article, we explore neurobiologic changes associated with trauma, PTSD, and SUD that underly dysregulated stress response. Examining lessons learned from recent translational and clinical research, we propose that further elucidating the neurobiologic etiology of comorbid PTSD and SUD will require a collaborative, interdisciplinary approach, including the integration of preclinical and clinical studies, exploration of biologic markers in clinical studies, and accumulation of larger studies and longitudinal studies with the power to study PTSD and SUD. Such research can transform the field and ultimately reduce high rates and costly impairment of co-occurring PTSD and SUD across the lifespan.
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spelling pubmed-94966542022-09-23 Elucidating the Neurobiologic Etiology of Comorbid PTSD and Substance Use Disorders Hinckley, Jesse D. Danielson, Carla Kmett Brain Sci Perspective Early childhood maltreatment and other traumatic event experiences (“trauma”) are common among youth, including those with substance use problems including substance use disorders (SUD). Particularly, interpersonal violence is associated with high rates of comorbidity between posttraumatic stress disorder (PTSD) and SUD, and these comorbid disorders exhibit high levels of overlapping symptomatology. Theoretical models proposed to explain the bidirectional relationship between PTSD and SUD include the self-medication hypothesis and susceptibility hypothesis. In this article, we explore neurobiologic changes associated with trauma, PTSD, and SUD that underly dysregulated stress response. Examining lessons learned from recent translational and clinical research, we propose that further elucidating the neurobiologic etiology of comorbid PTSD and SUD will require a collaborative, interdisciplinary approach, including the integration of preclinical and clinical studies, exploration of biologic markers in clinical studies, and accumulation of larger studies and longitudinal studies with the power to study PTSD and SUD. Such research can transform the field and ultimately reduce high rates and costly impairment of co-occurring PTSD and SUD across the lifespan. MDPI 2022-08-31 /pmc/articles/PMC9496654/ /pubmed/36138902 http://dx.doi.org/10.3390/brainsci12091166 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Perspective
Hinckley, Jesse D.
Danielson, Carla Kmett
Elucidating the Neurobiologic Etiology of Comorbid PTSD and Substance Use Disorders
title Elucidating the Neurobiologic Etiology of Comorbid PTSD and Substance Use Disorders
title_full Elucidating the Neurobiologic Etiology of Comorbid PTSD and Substance Use Disorders
title_fullStr Elucidating the Neurobiologic Etiology of Comorbid PTSD and Substance Use Disorders
title_full_unstemmed Elucidating the Neurobiologic Etiology of Comorbid PTSD and Substance Use Disorders
title_short Elucidating the Neurobiologic Etiology of Comorbid PTSD and Substance Use Disorders
title_sort elucidating the neurobiologic etiology of comorbid ptsd and substance use disorders
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9496654/
https://www.ncbi.nlm.nih.gov/pubmed/36138902
http://dx.doi.org/10.3390/brainsci12091166
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