A Charcot-Marie-Tooth-Causing Mutation in HSPB1 Decreases Cell Adaptation to Repeated Stress by Disrupting Autophagic Clearance of Misfolded Proteins

Charcot-Marie-Tooth (CMT) disease is the most common inherited neurodegenerative disorder with selective degeneration of peripheral nerves. Despite advances in identifying CMT-causing genes, the underlying molecular mechanism, particularly of selective degeneration of peripheral neurons remains to b...

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Detalles Bibliográficos
Autores principales: Zhang, Xuelian, Qiao, Yaru, Han, Ronglin, Gao, Yingjie, Yang, Xun, Zhang, Ying, Wan, Ying, Yu, Wei, Pan, Xianchao, Xing, Juan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9496658/
https://www.ncbi.nlm.nih.gov/pubmed/36139461
http://dx.doi.org/10.3390/cells11182886

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