Cargando…

Antigens Expressed by Breast Cancer Cells Undergoing EMT Stimulate Cytotoxic CD8(+) T Cell Immunity

SIMPLE SUMMARY: The transition of cells with epithelial characteristics to those with mesenchymal characteristics (termed EMT) facilitates breast cancer invasive capacity. The EMT program can also contribute to immunosuppressive and immunoevasive properties, altering susceptibility to immune cell re...

Descripción completa

Detalles Bibliográficos
Autores principales:	Camp, Faye A., Brunetti, Tonya M., Williams, Michelle M., Christenson, Jessica L., Sreekanth, Varsha, Costello, James C., Hay, Zachary L. Z., Kedl, Ross M., Richer, Jennifer K., Slansky, Jill E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9496737/ https://www.ncbi.nlm.nih.gov/pubmed/36139558 http://dx.doi.org/10.3390/cancers14184397

Ejemplares similares

Granzymes: The Molecular Executors of Immune-Mediated Cytotoxicity
por: Hay, Zachary L. Z., et al.
Publicado: (2022)

Dendritic cell subsets require cis-activation for cytotoxic CD8 T cell induction
por: Desch, A. Nicole, et al.
Publicado: (2014)

Implications of Antigen Selection on T Cell-Based Immunotherapy
por: Camp, Faye A., et al.
Publicado: (2021)

MicroRNA-200c restoration reveals a cytokine profile to enhance M1 macrophage polarization in breast cancer
por: Williams, Michelle M., et al.
Publicado: (2021)

Antigen-Specific T Cells: Analyses of the Needles in the Haystack
por: Slansky, Jill E
Publicado: (2003)

Low TCR Binding Strength Results in Increased Progenitor-like CD8(+) Tumor-Infiltrating Lymphocytes
por: Hay, Zachary L.Z., et al.
Publicado: (2023)

Tolerance of Tumor-Specific T cells in Melanoma Metastases
por: Waugh, Katherine A, et al.
Publicado: (2016)

Effect of cell density on intracellular adriamycin concentration and cytotoxicity in exponential and plateau phase EMT6 cells.
por: Chambers, S. H., et al.
Publicado: (1984)

Targeting Transcriptional Regulators of CD8+ T Cell Dysfunction to Boost Anti-Tumor Immunity
por: Waugh, Katherine A., et al.
Publicado: (2015)

Down but far from out: The durability of SARS-CoV-2 immunity after asymptomatic infection
por: Kedl, Ross M.
Publicado: (2021)

Publisher Correction: An immunological autobiography: my year as a COVID-19 vaccine trial participant
por: Kedl, Ross M.
Publicado: (2022)

An immunological autobiography: my year as a COVID-19 vaccine trial participant
por: Kedl, Ross M.
Publicado: (2022)

The response to cytotoxic drugs of EMT6 cells treated either as intact or disaggregated spheroids.
por: Kwok, T. T., et al.
Publicado: (1985)

Response of EMT6 multicellular tumour spheroids to hyperthermia and cytotoxic drugs.
por: Morgan, J. E., et al.
Publicado: (1981)

Antigen capture and archiving by lymphatic endothelial cells following vaccination or viral infection
por: Tamburini, Beth A, et al.
Publicado: (2014)

IL-27p28 Production by XCR1(+) Dendritic Cells and Monocytes Effectively Predicts Adjuvant-Elicited CD8(+) T Cell Responses
por: Kilgore, Augustus M., et al.
Publicado: (2018)

Hemin treatment drives viral reactivation and plasma cell differentiation of EBV latently infected B cells
por: Burnet, Anna M., et al.
Publicado: (2023)

Anti-CD8 monoclonal antibody-mediated depletion alters the phenotype and behavior of surviving CD8+ T cells
por: Cross, Eric W., et al.
Publicado: (2019)

Fsp1-Mediated Lineage Tracing Fails to Detect the Majority of Disseminating Cells Undergoing EMT
por: Bornes, Laura, et al.
Publicado: (2019)

Glomerular parietal epithelial cells of adult murine kidney undergo EMT to generate cells with traits of renal progenitors
por: G, Swetha, et al.
Publicado: (2011)

High content screening identifies monensin as an EMT-selective cytotoxic compound
por: Vanneste, Marion, et al.
Publicado: (2019)

T Cells Compete for Access to Antigen-Bearing Antigen-Presenting Cells
por: Kedl, Ross M., et al.
Publicado: (2000)

Migratory dendritic cells acquire and present lymphatic endothelial cell-archived antigens during lymph node contraction
por: Kedl, Ross M., et al.
Publicado: (2017)

Circulating tumor cells undergoing EMT are poorly correlated with clinical stages or predictive of recurrence in hepatocellular carcinoma
por: Chen, Yunyang, et al.
Publicado: (2019)

The Goldilocks Model for TCR—Too Much Attraction Might Not Be Best for Vaccine Design
por: Slansky, Jill E., et al.
Publicado: (2010)

Mimotope vaccine efficacy gets a "boost" from native tumor antigens
por: Buhrman, Jonathan D., et al.
Publicado: (2013)

News and views on EMT Fra-1 controls EMT in mammary epithelial cells
por: Bakiri, Latifa, et al.
Publicado: (2015)

Ena/VASP Protein-Mediated Actin Polymerization Contributes to Naïve CD8(+) T Cell Activation and Expansion by Promoting T Cell–APC Interactions In Vivo
por: Waldman, Monique M., et al.
Publicado: (2022)

Ribosome biogenesis during cell cycle arrest fuels EMT in development and disease
por: Prakash, Varsha, et al.
Publicado: (2019)

Common cytotoxic chemotherapeutics induce epithelial-mesenchymal transition (EMT) downstream of ER stress
por: Shah, Parag P., et al.
Publicado: (2017)

TCR hypervariable regions expressed by T cells that respond to effective tumor vaccines
por: Jordan, Kimberly R., et al.
Publicado: (2012)

Improving Antigenic Peptide Vaccines for Cancer Immunotherapy Using a Dominant Tumor-specific T Cell Receptor
por: Buhrman, Jonathan D., et al.
Publicado: (2013)

Should EMT of Cancer Cells Be Understood as Epithelial-Myeloid Transition?
por: Schramm, Henning M.
Publicado: (2014)

Prognostic Value of EMT-Circulating Tumor Cells in Metastatic Breast Cancer Patients Undergoing High-Dose Chemotherapy with Autologous Hematopoietic Stem Cell Transplantation
por: Mego, Michal, et al.
Publicado: (2012)

CMTM6 and CMTM7: New leads for PD‐L1 regulation in breast cancer cells undergoing EMT
por: Xiao, Malina, et al.
Publicado: (2022)

Antigen presentation by tumor infiltrating B cells influences CD4 T cell phenotype and function in primary lung cancer patient tumors
por: Bruno, Tullia, et al.
Publicado: (2015)

EMT circulating tumor cells detected by cell-surface vimentin are associated with prostate cancer progression
por: Satelli, Arun, et al.
Publicado: (2017)

Cell state plasticity, stem cells, EMT, and the generation of intra-tumoral heterogeneity
por: Wahl, Geoffrey M., et al.
Publicado: (2017)

Downregulation of E-cadherin in pluripotent stem cells triggers partial EMT
por: Aban, C. E., et al.
Publicado: (2021)

CD103(+) pulmonary dendritic cells preferentially acquire and present apoptotic cell–associated antigen
por: Desch, A. Nicole, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_d1kbefpl1ficedco3j8t1lm2hn