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Hospital Outcomes among COVID-19 Hospitalizations with Acute Ischemic Stroke: Cross-Sectional Study Results from California State Inpatient Database

Coronavirus disease 2019 (COVID-19) could be a risk factor for acute ischemic stroke (AIS) due to the altered coagulation process and hyperinflammation. This study examined the risk factors, clinical profile, and hospital outcomes of COVID-19 hospitalizations with AIS. This study was a retrospective...

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Autores principales: Rubens, Muni, Saxena, Anshul, Ramamoorthy, Venkataraghavan, Ahmed, Md Ashfaq, Zhang, Zhenwei, McGranaghan, Peter, Veledar, Emir, McDermott, Michael, De Los Rios La Rosa, Felipe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9496747/
https://www.ncbi.nlm.nih.gov/pubmed/36138913
http://dx.doi.org/10.3390/brainsci12091177
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author Rubens, Muni
Saxena, Anshul
Ramamoorthy, Venkataraghavan
Ahmed, Md Ashfaq
Zhang, Zhenwei
McGranaghan, Peter
Veledar, Emir
McDermott, Michael
De Los Rios La Rosa, Felipe
author_facet Rubens, Muni
Saxena, Anshul
Ramamoorthy, Venkataraghavan
Ahmed, Md Ashfaq
Zhang, Zhenwei
McGranaghan, Peter
Veledar, Emir
McDermott, Michael
De Los Rios La Rosa, Felipe
author_sort Rubens, Muni
collection PubMed
description Coronavirus disease 2019 (COVID-19) could be a risk factor for acute ischemic stroke (AIS) due to the altered coagulation process and hyperinflammation. This study examined the risk factors, clinical profile, and hospital outcomes of COVID-19 hospitalizations with AIS. This study was a retrospective analysis of data from California State Inpatient Database (SID) during 2019 and 2020. COVID-19 hospitalizations with age ≥ 18 years during 2020 and a historical cohort without COVID-19 from 2019 were included in the analysis. The primary outcomes studied were in-hospital mortality and discharge to destinations other than home. There were 91,420 COVID-19 hospitalizations, of which, 1027 (1.1%) had AIS. The historical control cohort included 58,083 AIS hospitalizations without COVID-19. Conditional logistic regression analysis showed that the odds of in-hospital mortality, discharge to destinations other than home, DVT, pulmonary embolism, septic shock, and mechanical ventilation were significantly higher among COVID-19 hospitalizations with AIS, compared to those without AIS. The odds of in-hospital mortality, DVT, pulmonary embolism, septic shock, mechanical ventilation, and respiratory failure were significantly higher among COVID-19 hospitalizations with AIS, compared to AIS hospitalizations without COVID-19. Although the prevalence of AIS was low among COVID-19 hospitalizations, it was associated with higher mortality and greater rates of discharges to destinations other than home.
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spelling pubmed-94967472022-09-23 Hospital Outcomes among COVID-19 Hospitalizations with Acute Ischemic Stroke: Cross-Sectional Study Results from California State Inpatient Database Rubens, Muni Saxena, Anshul Ramamoorthy, Venkataraghavan Ahmed, Md Ashfaq Zhang, Zhenwei McGranaghan, Peter Veledar, Emir McDermott, Michael De Los Rios La Rosa, Felipe Brain Sci Article Coronavirus disease 2019 (COVID-19) could be a risk factor for acute ischemic stroke (AIS) due to the altered coagulation process and hyperinflammation. This study examined the risk factors, clinical profile, and hospital outcomes of COVID-19 hospitalizations with AIS. This study was a retrospective analysis of data from California State Inpatient Database (SID) during 2019 and 2020. COVID-19 hospitalizations with age ≥ 18 years during 2020 and a historical cohort without COVID-19 from 2019 were included in the analysis. The primary outcomes studied were in-hospital mortality and discharge to destinations other than home. There were 91,420 COVID-19 hospitalizations, of which, 1027 (1.1%) had AIS. The historical control cohort included 58,083 AIS hospitalizations without COVID-19. Conditional logistic regression analysis showed that the odds of in-hospital mortality, discharge to destinations other than home, DVT, pulmonary embolism, septic shock, and mechanical ventilation were significantly higher among COVID-19 hospitalizations with AIS, compared to those without AIS. The odds of in-hospital mortality, DVT, pulmonary embolism, septic shock, mechanical ventilation, and respiratory failure were significantly higher among COVID-19 hospitalizations with AIS, compared to AIS hospitalizations without COVID-19. Although the prevalence of AIS was low among COVID-19 hospitalizations, it was associated with higher mortality and greater rates of discharges to destinations other than home. MDPI 2022-09-01 /pmc/articles/PMC9496747/ /pubmed/36138913 http://dx.doi.org/10.3390/brainsci12091177 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Rubens, Muni
Saxena, Anshul
Ramamoorthy, Venkataraghavan
Ahmed, Md Ashfaq
Zhang, Zhenwei
McGranaghan, Peter
Veledar, Emir
McDermott, Michael
De Los Rios La Rosa, Felipe
Hospital Outcomes among COVID-19 Hospitalizations with Acute Ischemic Stroke: Cross-Sectional Study Results from California State Inpatient Database
title Hospital Outcomes among COVID-19 Hospitalizations with Acute Ischemic Stroke: Cross-Sectional Study Results from California State Inpatient Database
title_full Hospital Outcomes among COVID-19 Hospitalizations with Acute Ischemic Stroke: Cross-Sectional Study Results from California State Inpatient Database
title_fullStr Hospital Outcomes among COVID-19 Hospitalizations with Acute Ischemic Stroke: Cross-Sectional Study Results from California State Inpatient Database
title_full_unstemmed Hospital Outcomes among COVID-19 Hospitalizations with Acute Ischemic Stroke: Cross-Sectional Study Results from California State Inpatient Database
title_short Hospital Outcomes among COVID-19 Hospitalizations with Acute Ischemic Stroke: Cross-Sectional Study Results from California State Inpatient Database
title_sort hospital outcomes among covid-19 hospitalizations with acute ischemic stroke: cross-sectional study results from california state inpatient database
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9496747/
https://www.ncbi.nlm.nih.gov/pubmed/36138913
http://dx.doi.org/10.3390/brainsci12091177
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