Co-Targeting MAP Kinase and Pi3K-Akt-mTOR Pathways in Meningioma: Preclinical Study of Alpelisib and Trametinib

SIMPLE SUMMARY: Multi recurrent or high-grade meningiomas remain an unmet medical need in neuro-oncology. Several studies have highlighted the potential therapeutic efficacy of mTor inhibitors to control tumoral growth of meningiomas. However, a positive feedback on AKT oncogenic pathway from these...

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Detalles Bibliográficos
Autores principales: Mondielli, Gregoire, Mougel, Gregory, Darriet, Florent, Roche, Catherine, Querdray, Adeline, Lisbonis, Christophe, Appay, Romain, Dufour, Henry, Chinot, Olivier, Graillon, Thomas, Barlier, Anne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9496760/
https://www.ncbi.nlm.nih.gov/pubmed/36139608
http://dx.doi.org/10.3390/cancers14184448

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9496760/
https://www.ncbi.nlm.nih.gov/pubmed/36139608
http://dx.doi.org/10.3390/cancers14184448

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