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Sirtuin 1 in Host Defense during Infection
Sirtuins (SIRTs) are members of the class III histone deacetylase family and epigenetically control multiple target genes to modulate diverse biological responses in cells. Among the SIRTs, SIRT1 is the most well-studied, with a role in the modulation of immune and inflammatory responses following i...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9496836/ https://www.ncbi.nlm.nih.gov/pubmed/36139497 http://dx.doi.org/10.3390/cells11182921 |
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author | Kim, Jin Kyung Silwal, Prashanta Jo, Eun-Kyeong |
author_facet | Kim, Jin Kyung Silwal, Prashanta Jo, Eun-Kyeong |
author_sort | Kim, Jin Kyung |
collection | PubMed |
description | Sirtuins (SIRTs) are members of the class III histone deacetylase family and epigenetically control multiple target genes to modulate diverse biological responses in cells. Among the SIRTs, SIRT1 is the most well-studied, with a role in the modulation of immune and inflammatory responses following infection. The functions of SIRT1 include orchestrating immune, inflammatory, metabolic, and autophagic responses, all of which are required in establishing and controlling host defenses during infection. In this review, we summarize recent information on the roles of SIRT1 and its regulatory mechanisms during bacterial, viral, and parasitic infections. We also discuss several SIRT1 modulators, as potential antimicrobial treatments. Understanding the function of SIRT1 in balancing immune homeostasis will contribute to the development of new therapeutics for the treatment of infection and inflammatory disease. |
format | Online Article Text |
id | pubmed-9496836 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94968362022-09-23 Sirtuin 1 in Host Defense during Infection Kim, Jin Kyung Silwal, Prashanta Jo, Eun-Kyeong Cells Review Sirtuins (SIRTs) are members of the class III histone deacetylase family and epigenetically control multiple target genes to modulate diverse biological responses in cells. Among the SIRTs, SIRT1 is the most well-studied, with a role in the modulation of immune and inflammatory responses following infection. The functions of SIRT1 include orchestrating immune, inflammatory, metabolic, and autophagic responses, all of which are required in establishing and controlling host defenses during infection. In this review, we summarize recent information on the roles of SIRT1 and its regulatory mechanisms during bacterial, viral, and parasitic infections. We also discuss several SIRT1 modulators, as potential antimicrobial treatments. Understanding the function of SIRT1 in balancing immune homeostasis will contribute to the development of new therapeutics for the treatment of infection and inflammatory disease. MDPI 2022-09-19 /pmc/articles/PMC9496836/ /pubmed/36139497 http://dx.doi.org/10.3390/cells11182921 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Kim, Jin Kyung Silwal, Prashanta Jo, Eun-Kyeong Sirtuin 1 in Host Defense during Infection |
title | Sirtuin 1 in Host Defense during Infection |
title_full | Sirtuin 1 in Host Defense during Infection |
title_fullStr | Sirtuin 1 in Host Defense during Infection |
title_full_unstemmed | Sirtuin 1 in Host Defense during Infection |
title_short | Sirtuin 1 in Host Defense during Infection |
title_sort | sirtuin 1 in host defense during infection |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9496836/ https://www.ncbi.nlm.nih.gov/pubmed/36139497 http://dx.doi.org/10.3390/cells11182921 |
work_keys_str_mv | AT kimjinkyung sirtuin1inhostdefenseduringinfection AT silwalprashanta sirtuin1inhostdefenseduringinfection AT joeunkyeong sirtuin1inhostdefenseduringinfection |