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CRL4(CRBN) E3 Ligase Complex as a Therapeutic Target in Multiple Myeloma

SIMPLE SUMMARY: Immunomodulatory drugs (IMiDs) are effective in the treatment of multiple myeloma (MM) and other hematological malignancies. Cereblon (CRBN), a target of IMiDs, forms the CRL4 E3 ubiquitin ligase complex (CRL4(CRBN)) with DDB1, CUL4A and RBX1. The insight into the molecular mechanism...

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Detalles Bibliográficos
Autores principales:	Barankiewicz, Joanna, Salomon-Perzyński, Aleksander, Misiewicz-Krzemińska, Irena, Lech-Marańda, Ewa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9496858/ https://www.ncbi.nlm.nih.gov/pubmed/36139651 http://dx.doi.org/10.3390/cancers14184492

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