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Mechanisms Controlling MicroRNA Expression in Tumor

MicroRNAs (miRNAs) are widely present in many organisms and regulate the expression of genes in various biological processes such as cell differentiation, metabolism, and development. Numerous studies have shown that miRNAs are abnormally expressed in tumor tissues and are closely associated with tu...

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Autores principales: Chen, Shipeng, Wang, Ya, Li, Dongmei, Wang, Hui, Zhao, Xu, Yang, Jing, Chen, Longqing, Guo, Mengmeng, Zhao, Juanjuan, Chen, Chao, Zhou, Ya, Liang, Guiyou, Xu, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9496884/
https://www.ncbi.nlm.nih.gov/pubmed/36139427
http://dx.doi.org/10.3390/cells11182852
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author Chen, Shipeng
Wang, Ya
Li, Dongmei
Wang, Hui
Zhao, Xu
Yang, Jing
Chen, Longqing
Guo, Mengmeng
Zhao, Juanjuan
Chen, Chao
Zhou, Ya
Liang, Guiyou
Xu, Lin
author_facet Chen, Shipeng
Wang, Ya
Li, Dongmei
Wang, Hui
Zhao, Xu
Yang, Jing
Chen, Longqing
Guo, Mengmeng
Zhao, Juanjuan
Chen, Chao
Zhou, Ya
Liang, Guiyou
Xu, Lin
author_sort Chen, Shipeng
collection PubMed
description MicroRNAs (miRNAs) are widely present in many organisms and regulate the expression of genes in various biological processes such as cell differentiation, metabolism, and development. Numerous studies have shown that miRNAs are abnormally expressed in tumor tissues and are closely associated with tumorigenesis. MiRNA-based cancer gene therapy has consistently shown promising anti-tumor effects and is recognized as a new field in cancer treatment. So far, some clinical trials involving the treatment of malignancies have been carried out; however, studies of miRNA-based cancer gene therapy are still proceeding slowly. Therefore, furthering our understanding of the regulatory mechanisms of miRNA can bring substantial benefits to the development of miRNA-based gene therapy or other combination therapies and the clinical outcome of patients with cancer. Recent studies have revealed that the aberrant expression of miRNA in tumors is associated with promoter sequence mutation, epigenetic alteration, aberrant RNA modification, etc., showing the complexity of aberrant expression mechanisms of miRNA in tumors. In this paper, we systematically summarized the regulation mechanisms of miRNA expression in tumors, with the aim of providing assistance in the subsequent elucidation of the role of miRNA in tumorigenesis and the development of new strategies for tumor prevention and treatment.
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spelling pubmed-94968842022-09-23 Mechanisms Controlling MicroRNA Expression in Tumor Chen, Shipeng Wang, Ya Li, Dongmei Wang, Hui Zhao, Xu Yang, Jing Chen, Longqing Guo, Mengmeng Zhao, Juanjuan Chen, Chao Zhou, Ya Liang, Guiyou Xu, Lin Cells Review MicroRNAs (miRNAs) are widely present in many organisms and regulate the expression of genes in various biological processes such as cell differentiation, metabolism, and development. Numerous studies have shown that miRNAs are abnormally expressed in tumor tissues and are closely associated with tumorigenesis. MiRNA-based cancer gene therapy has consistently shown promising anti-tumor effects and is recognized as a new field in cancer treatment. So far, some clinical trials involving the treatment of malignancies have been carried out; however, studies of miRNA-based cancer gene therapy are still proceeding slowly. Therefore, furthering our understanding of the regulatory mechanisms of miRNA can bring substantial benefits to the development of miRNA-based gene therapy or other combination therapies and the clinical outcome of patients with cancer. Recent studies have revealed that the aberrant expression of miRNA in tumors is associated with promoter sequence mutation, epigenetic alteration, aberrant RNA modification, etc., showing the complexity of aberrant expression mechanisms of miRNA in tumors. In this paper, we systematically summarized the regulation mechanisms of miRNA expression in tumors, with the aim of providing assistance in the subsequent elucidation of the role of miRNA in tumorigenesis and the development of new strategies for tumor prevention and treatment. MDPI 2022-09-13 /pmc/articles/PMC9496884/ /pubmed/36139427 http://dx.doi.org/10.3390/cells11182852 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Chen, Shipeng
Wang, Ya
Li, Dongmei
Wang, Hui
Zhao, Xu
Yang, Jing
Chen, Longqing
Guo, Mengmeng
Zhao, Juanjuan
Chen, Chao
Zhou, Ya
Liang, Guiyou
Xu, Lin
Mechanisms Controlling MicroRNA Expression in Tumor
title Mechanisms Controlling MicroRNA Expression in Tumor
title_full Mechanisms Controlling MicroRNA Expression in Tumor
title_fullStr Mechanisms Controlling MicroRNA Expression in Tumor
title_full_unstemmed Mechanisms Controlling MicroRNA Expression in Tumor
title_short Mechanisms Controlling MicroRNA Expression in Tumor
title_sort mechanisms controlling microrna expression in tumor
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9496884/
https://www.ncbi.nlm.nih.gov/pubmed/36139427
http://dx.doi.org/10.3390/cells11182852
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