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Mechanisms Controlling MicroRNA Expression in Tumor
MicroRNAs (miRNAs) are widely present in many organisms and regulate the expression of genes in various biological processes such as cell differentiation, metabolism, and development. Numerous studies have shown that miRNAs are abnormally expressed in tumor tissues and are closely associated with tu...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9496884/ https://www.ncbi.nlm.nih.gov/pubmed/36139427 http://dx.doi.org/10.3390/cells11182852 |
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author | Chen, Shipeng Wang, Ya Li, Dongmei Wang, Hui Zhao, Xu Yang, Jing Chen, Longqing Guo, Mengmeng Zhao, Juanjuan Chen, Chao Zhou, Ya Liang, Guiyou Xu, Lin |
author_facet | Chen, Shipeng Wang, Ya Li, Dongmei Wang, Hui Zhao, Xu Yang, Jing Chen, Longqing Guo, Mengmeng Zhao, Juanjuan Chen, Chao Zhou, Ya Liang, Guiyou Xu, Lin |
author_sort | Chen, Shipeng |
collection | PubMed |
description | MicroRNAs (miRNAs) are widely present in many organisms and regulate the expression of genes in various biological processes such as cell differentiation, metabolism, and development. Numerous studies have shown that miRNAs are abnormally expressed in tumor tissues and are closely associated with tumorigenesis. MiRNA-based cancer gene therapy has consistently shown promising anti-tumor effects and is recognized as a new field in cancer treatment. So far, some clinical trials involving the treatment of malignancies have been carried out; however, studies of miRNA-based cancer gene therapy are still proceeding slowly. Therefore, furthering our understanding of the regulatory mechanisms of miRNA can bring substantial benefits to the development of miRNA-based gene therapy or other combination therapies and the clinical outcome of patients with cancer. Recent studies have revealed that the aberrant expression of miRNA in tumors is associated with promoter sequence mutation, epigenetic alteration, aberrant RNA modification, etc., showing the complexity of aberrant expression mechanisms of miRNA in tumors. In this paper, we systematically summarized the regulation mechanisms of miRNA expression in tumors, with the aim of providing assistance in the subsequent elucidation of the role of miRNA in tumorigenesis and the development of new strategies for tumor prevention and treatment. |
format | Online Article Text |
id | pubmed-9496884 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94968842022-09-23 Mechanisms Controlling MicroRNA Expression in Tumor Chen, Shipeng Wang, Ya Li, Dongmei Wang, Hui Zhao, Xu Yang, Jing Chen, Longqing Guo, Mengmeng Zhao, Juanjuan Chen, Chao Zhou, Ya Liang, Guiyou Xu, Lin Cells Review MicroRNAs (miRNAs) are widely present in many organisms and regulate the expression of genes in various biological processes such as cell differentiation, metabolism, and development. Numerous studies have shown that miRNAs are abnormally expressed in tumor tissues and are closely associated with tumorigenesis. MiRNA-based cancer gene therapy has consistently shown promising anti-tumor effects and is recognized as a new field in cancer treatment. So far, some clinical trials involving the treatment of malignancies have been carried out; however, studies of miRNA-based cancer gene therapy are still proceeding slowly. Therefore, furthering our understanding of the regulatory mechanisms of miRNA can bring substantial benefits to the development of miRNA-based gene therapy or other combination therapies and the clinical outcome of patients with cancer. Recent studies have revealed that the aberrant expression of miRNA in tumors is associated with promoter sequence mutation, epigenetic alteration, aberrant RNA modification, etc., showing the complexity of aberrant expression mechanisms of miRNA in tumors. In this paper, we systematically summarized the regulation mechanisms of miRNA expression in tumors, with the aim of providing assistance in the subsequent elucidation of the role of miRNA in tumorigenesis and the development of new strategies for tumor prevention and treatment. MDPI 2022-09-13 /pmc/articles/PMC9496884/ /pubmed/36139427 http://dx.doi.org/10.3390/cells11182852 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Chen, Shipeng Wang, Ya Li, Dongmei Wang, Hui Zhao, Xu Yang, Jing Chen, Longqing Guo, Mengmeng Zhao, Juanjuan Chen, Chao Zhou, Ya Liang, Guiyou Xu, Lin Mechanisms Controlling MicroRNA Expression in Tumor |
title | Mechanisms Controlling MicroRNA Expression in Tumor |
title_full | Mechanisms Controlling MicroRNA Expression in Tumor |
title_fullStr | Mechanisms Controlling MicroRNA Expression in Tumor |
title_full_unstemmed | Mechanisms Controlling MicroRNA Expression in Tumor |
title_short | Mechanisms Controlling MicroRNA Expression in Tumor |
title_sort | mechanisms controlling microrna expression in tumor |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9496884/ https://www.ncbi.nlm.nih.gov/pubmed/36139427 http://dx.doi.org/10.3390/cells11182852 |
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