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Impact of Rural vs. Urban Residence on Survival Rates of Patients with Glioblastoma: A Tertiary Care Center Experience

Purpose: Although the association between residential location and survival in patients with different cancer types has been established, the conclusions are contentious, and the underlying mechanisms remain unknown. Here, we reviewed the impact of residence on the survival of patients with glioblas...

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Autores principales: Alwadei, Ali, Alnaami, Ibrahim, Alenazy, Kawthar, Marei, Amal, BaHammam, Leenh O., Nasser, Sameh, Alswilem, Abdullah Mansour, Maklad, Ahmed, Shehata, Shehata F., Alqahtani, Mohammad Salem, Al-Shahrani, Abdulelah, Balbaid, Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9496950/
https://www.ncbi.nlm.nih.gov/pubmed/36138922
http://dx.doi.org/10.3390/brainsci12091186
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author Alwadei, Ali
Alnaami, Ibrahim
Alenazy, Kawthar
Marei, Amal
BaHammam, Leenh O.
Nasser, Sameh
Alswilem, Abdullah Mansour
Maklad, Ahmed
Shehata, Shehata F.
Alqahtani, Mohammad Salem
Al-Shahrani, Abdulelah
Balbaid, Ali
author_facet Alwadei, Ali
Alnaami, Ibrahim
Alenazy, Kawthar
Marei, Amal
BaHammam, Leenh O.
Nasser, Sameh
Alswilem, Abdullah Mansour
Maklad, Ahmed
Shehata, Shehata F.
Alqahtani, Mohammad Salem
Al-Shahrani, Abdulelah
Balbaid, Ali
author_sort Alwadei, Ali
collection PubMed
description Purpose: Although the association between residential location and survival in patients with different cancer types has been established, the conclusions are contentious, and the underlying mechanisms remain unknown. Here, we reviewed the impact of residence on the survival of patients with glioblastoma (GBM). Methods: We conducted a retrospective study to compare the impact of rural and urban residence on the survival rates of patients with GBM diagnosed in Riyadh City and outside Riyadh. All patients in this study were treated in a tertiary care hospital, and their survival rates were analyzed in relation to their residence and other related factors, namely radiotherapy timing. Results: Overall, 125 patients were included: 61 from Riyadh City and 64 from outside. The majority of patients in both groups were aged >50 years (p = 0.814). There was no statistically significant difference between the groups in the Eastern Cooperative Oncology Group Performance Status (p = 0.430), seizure (p = 0.858), or initiation timing of radiotherapy (p = 0.781). Furthermore, the median survival rate in the Riyadh group versus the other group was 14.4 months and 12.2 months, respectively, with no statistical significance (p = 0.187). Conclusions: Our study showed that residential location had no significant effect on GBM prognosis. However, further studies with a larger sample size are required to delineate the other factors of referral within the healthcare system to facilitate the management of these patients within a specific timeframe.
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spelling pubmed-94969502022-09-23 Impact of Rural vs. Urban Residence on Survival Rates of Patients with Glioblastoma: A Tertiary Care Center Experience Alwadei, Ali Alnaami, Ibrahim Alenazy, Kawthar Marei, Amal BaHammam, Leenh O. Nasser, Sameh Alswilem, Abdullah Mansour Maklad, Ahmed Shehata, Shehata F. Alqahtani, Mohammad Salem Al-Shahrani, Abdulelah Balbaid, Ali Brain Sci Article Purpose: Although the association between residential location and survival in patients with different cancer types has been established, the conclusions are contentious, and the underlying mechanisms remain unknown. Here, we reviewed the impact of residence on the survival of patients with glioblastoma (GBM). Methods: We conducted a retrospective study to compare the impact of rural and urban residence on the survival rates of patients with GBM diagnosed in Riyadh City and outside Riyadh. All patients in this study were treated in a tertiary care hospital, and their survival rates were analyzed in relation to their residence and other related factors, namely radiotherapy timing. Results: Overall, 125 patients were included: 61 from Riyadh City and 64 from outside. The majority of patients in both groups were aged >50 years (p = 0.814). There was no statistically significant difference between the groups in the Eastern Cooperative Oncology Group Performance Status (p = 0.430), seizure (p = 0.858), or initiation timing of radiotherapy (p = 0.781). Furthermore, the median survival rate in the Riyadh group versus the other group was 14.4 months and 12.2 months, respectively, with no statistical significance (p = 0.187). Conclusions: Our study showed that residential location had no significant effect on GBM prognosis. However, further studies with a larger sample size are required to delineate the other factors of referral within the healthcare system to facilitate the management of these patients within a specific timeframe. MDPI 2022-09-02 /pmc/articles/PMC9496950/ /pubmed/36138922 http://dx.doi.org/10.3390/brainsci12091186 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Alwadei, Ali
Alnaami, Ibrahim
Alenazy, Kawthar
Marei, Amal
BaHammam, Leenh O.
Nasser, Sameh
Alswilem, Abdullah Mansour
Maklad, Ahmed
Shehata, Shehata F.
Alqahtani, Mohammad Salem
Al-Shahrani, Abdulelah
Balbaid, Ali
Impact of Rural vs. Urban Residence on Survival Rates of Patients with Glioblastoma: A Tertiary Care Center Experience
title Impact of Rural vs. Urban Residence on Survival Rates of Patients with Glioblastoma: A Tertiary Care Center Experience
title_full Impact of Rural vs. Urban Residence on Survival Rates of Patients with Glioblastoma: A Tertiary Care Center Experience
title_fullStr Impact of Rural vs. Urban Residence on Survival Rates of Patients with Glioblastoma: A Tertiary Care Center Experience
title_full_unstemmed Impact of Rural vs. Urban Residence on Survival Rates of Patients with Glioblastoma: A Tertiary Care Center Experience
title_short Impact of Rural vs. Urban Residence on Survival Rates of Patients with Glioblastoma: A Tertiary Care Center Experience
title_sort impact of rural vs. urban residence on survival rates of patients with glioblastoma: a tertiary care center experience
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9496950/
https://www.ncbi.nlm.nih.gov/pubmed/36138922
http://dx.doi.org/10.3390/brainsci12091186
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