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Leveraging the Dynamic Immune Environment Triad in Patients with Breast Cancer: Tumour, Lymph Node, and Peripheral Blood

SIMPLE SUMMARY: The primary, secondary and tertiary immune sites, namely the tumour microenvironment (TME), the lymph nodes (LNs) and the peripheral blood, form the cardinal trinity of immune environments in breast cancer. With the success of immuno-therapies in some subtypes of breast cancers, an i...

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Autores principales: Wall, Isobelle, Boulat, Victoire, Shah, Aekta, Blenman, Kim R. M., Wu, Yin, Alberts, Elena, Calado, Dinis Pedro, Salgado, Roberto, Grigoriadis, Anita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9496983/
https://www.ncbi.nlm.nih.gov/pubmed/36139665
http://dx.doi.org/10.3390/cancers14184505
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author Wall, Isobelle
Boulat, Victoire
Shah, Aekta
Blenman, Kim R. M.
Wu, Yin
Alberts, Elena
Calado, Dinis Pedro
Salgado, Roberto
Grigoriadis, Anita
author_facet Wall, Isobelle
Boulat, Victoire
Shah, Aekta
Blenman, Kim R. M.
Wu, Yin
Alberts, Elena
Calado, Dinis Pedro
Salgado, Roberto
Grigoriadis, Anita
author_sort Wall, Isobelle
collection PubMed
description SIMPLE SUMMARY: The primary, secondary and tertiary immune sites, namely the tumour microenvironment (TME), the lymph nodes (LNs) and the peripheral blood, form the cardinal trinity of immune environments in breast cancer. With the success of immuno-therapies in some subtypes of breast cancers, an integrated understanding of these intertwined immune sites is essential to potentiate their anti-cancer responses and enhance the efficacies of therapeutic agents, and in turn, illuminate novel pathways of anti-cancer immunity and therapeutic opportunities. ABSTRACT: During the anti-tumour response to breast cancer, the primary tumour, the peripheral blood, and the lymph nodes each play unique roles. Immunological features at each site reveal evidence of continuous immune cross-talk between them before, during and after treatment. As such, immune responses to breast cancer are found to be highly dynamic and truly systemic, integrating three distinct immune sites, complex cell-migration highways, as well as the temporal dimension of disease progression and treatment. In this review, we provide a connective summary of the dynamic immune environment triad of breast cancer. It is critical that future studies seek to establish dynamic immune profiles, constituting multiple sites, that capture the systemic immune response to breast cancer and define patient-selection parameters resulting in more significant overall responses and survival rates for breast cancer patients.
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spelling pubmed-94969832022-09-23 Leveraging the Dynamic Immune Environment Triad in Patients with Breast Cancer: Tumour, Lymph Node, and Peripheral Blood Wall, Isobelle Boulat, Victoire Shah, Aekta Blenman, Kim R. M. Wu, Yin Alberts, Elena Calado, Dinis Pedro Salgado, Roberto Grigoriadis, Anita Cancers (Basel) Review SIMPLE SUMMARY: The primary, secondary and tertiary immune sites, namely the tumour microenvironment (TME), the lymph nodes (LNs) and the peripheral blood, form the cardinal trinity of immune environments in breast cancer. With the success of immuno-therapies in some subtypes of breast cancers, an integrated understanding of these intertwined immune sites is essential to potentiate their anti-cancer responses and enhance the efficacies of therapeutic agents, and in turn, illuminate novel pathways of anti-cancer immunity and therapeutic opportunities. ABSTRACT: During the anti-tumour response to breast cancer, the primary tumour, the peripheral blood, and the lymph nodes each play unique roles. Immunological features at each site reveal evidence of continuous immune cross-talk between them before, during and after treatment. As such, immune responses to breast cancer are found to be highly dynamic and truly systemic, integrating three distinct immune sites, complex cell-migration highways, as well as the temporal dimension of disease progression and treatment. In this review, we provide a connective summary of the dynamic immune environment triad of breast cancer. It is critical that future studies seek to establish dynamic immune profiles, constituting multiple sites, that capture the systemic immune response to breast cancer and define patient-selection parameters resulting in more significant overall responses and survival rates for breast cancer patients. MDPI 2022-09-17 /pmc/articles/PMC9496983/ /pubmed/36139665 http://dx.doi.org/10.3390/cancers14184505 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Wall, Isobelle
Boulat, Victoire
Shah, Aekta
Blenman, Kim R. M.
Wu, Yin
Alberts, Elena
Calado, Dinis Pedro
Salgado, Roberto
Grigoriadis, Anita
Leveraging the Dynamic Immune Environment Triad in Patients with Breast Cancer: Tumour, Lymph Node, and Peripheral Blood
title Leveraging the Dynamic Immune Environment Triad in Patients with Breast Cancer: Tumour, Lymph Node, and Peripheral Blood
title_full Leveraging the Dynamic Immune Environment Triad in Patients with Breast Cancer: Tumour, Lymph Node, and Peripheral Blood
title_fullStr Leveraging the Dynamic Immune Environment Triad in Patients with Breast Cancer: Tumour, Lymph Node, and Peripheral Blood
title_full_unstemmed Leveraging the Dynamic Immune Environment Triad in Patients with Breast Cancer: Tumour, Lymph Node, and Peripheral Blood
title_short Leveraging the Dynamic Immune Environment Triad in Patients with Breast Cancer: Tumour, Lymph Node, and Peripheral Blood
title_sort leveraging the dynamic immune environment triad in patients with breast cancer: tumour, lymph node, and peripheral blood
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9496983/
https://www.ncbi.nlm.nih.gov/pubmed/36139665
http://dx.doi.org/10.3390/cancers14184505
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