Inhibition of BRD4 Promotes Pexophagy by Increasing ROS and ATM Activation

Although autophagy regulates the quality and quantity of cellular compartments, the regulatory mechanisms underlying peroxisomal autophagy (pexophagy) remain largely unknown. In this study, we identified several BRD4 inhibitors, including molibresib, a novel pexophagy inducer, via chemical library s...

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Detalles Bibliográficos
Autores principales: Kim, Yong Hwan, Jo, Doo Sin, Park, Na Yeon, Bae, Ji-Eun, Kim, Joon Bum, Lee, Ha Jung, Kim, So Hyun, Kim, Seong Hyun, Lee, Sunwoo, Son, Mikyung, Park, Kyuhee, Jeong, Kwiwan, Yeom, Eunbyul, Cho, Dong-Hyung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9497081/
https://www.ncbi.nlm.nih.gov/pubmed/36139416
http://dx.doi.org/10.3390/cells11182839

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