A Review on Annona muricata and Its Anticancer Activity

SIMPLE SUMMARY: Cancer is becoming more prevalent, raising concerns regarding how well current treatments work. Cancer patients frequently seek alternative treatments to surgery, chemotherapy, and radiation therapy. The use of medicinal plants in both preventative and curative healthcare is widely acknowledged. The compounds of graviola have shown promise as possible cancer-fighting agents and could be used to treat cancer. This review discusses bioactive metabolites present in graviola and their role in affecting the growth and death of different cancer cell types and the molecular mechanism of how it works to downregulate anti-apoptotic genes and the genes involved in pro-cancer metabolic pathways. Also, it reviews how simultaneously increasing the expression of genes promotes apoptosis and causes cancer cells to die so that the active phytochemicals found in graviola could be used as a promising anti-cancer agent. ABSTRACT: The ongoing rise in the number of cancer cases raises concerns regarding the efficacy of the various treatment methods that are currently available. Consequently, patients are looking for alternatives to traditional cancer treatments such as surgery, chemotherapy, and radiotherapy as a replacement. Medicinal plants are universally acknowledged as the cornerstone of preventative medicine and therapeutic practices. Annona muricata is a member of the family Annonaceae and is familiar for its medicinal properties. A. muricata has been identified to have promising compounds that could potentially be utilized for the treatment of cancer. The most prevalent phytochemical components identified and isolated from this plant are alkaloids, phenols, and acetogenins. This review focuses on the role of A. muricata extract against various types of cancer, modulation of cellular proliferation and necrosis, and bioactive metabolites responsible for various pharmacological activities along with their ethnomedicinal uses. Additionally, this review highlights the molecular mechanism of the role of A. muricata extract in downregulating anti-apoptotic and several genes involved in the pro-cancer metabolic pathways and decreasing the expression of proteins involved in cell invasion and metastasis while upregulating proapoptotic genes and genes involved in the destruction of cancer cells. Therefore, the active phytochemicals identified in A. muricata have the potential to be employed as a promising anti-cancer agent.