Cargando…
CtIP Regulates Mitotic Spindle Assembly by Modulating the TPX2-Aurora A Signaling Axis
CtBP-interacting protein (CtIP) plays a critical role in controlling the homologous recombination-mediated DNA double-stranded break (DSB) repair pathway through DNA end resection, and recent studies suggest that it also plays a role in mitosis. However, the mechanism by which CtIP contributes to mi...
Autores principales: | Oh, Wonkyung, Wu, Ting Ting, Jeong, Seo-Yeon, You, Ho Jin, Lee, Jung-Hee |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9497199/ https://www.ncbi.nlm.nih.gov/pubmed/36139389 http://dx.doi.org/10.3390/cells11182814 |
Ejemplares similares
-
PP6 regulation of Aurora A–TPX2 limits NDC80 phosphorylation and mitotic spindle size
por: Sobajima, Tomoaki, et al.
Publicado: (2023) -
CtIP is essential for telomere replication
por: Stroik, Susanna, et al.
Publicado: (2019) -
Human TPX2 is required for targeting Aurora-A kinase to the spindle
por: Kufer, Thomas A., et al.
Publicado: (2002) -
CtIP tetramer assembly is required for DNA-end resection and repair
por: Davies, Owen R., et al.
Publicado: (2015) -
Protein phosphatase 6 regulates mitotic spindle formation by controlling the T-loop phosphorylation state of Aurora A bound to its activator TPX2
por: Zeng, Kang, et al.
Publicado: (2010)