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Relationship between Coronary Arterial Geometry and the Presence and Extend of Atherosclerotic Plaque Burden: A Review Discussing Methodology and Findings in the Era of Cardiac Computed Tomography Angiography
Coronary artery disease (CAD) represents a modern pandemic associated with significant morbidity and mortality. The multi-faceted pathogenesis of this entity has long been investigated, highlighting the contribution of systemic factors such as hyperlipidemia and hypertension. Nevertheless, recent re...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9497479/ https://www.ncbi.nlm.nih.gov/pubmed/36140578 http://dx.doi.org/10.3390/diagnostics12092178 |
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author | Rampidis, Georgios Rafailidis, Vasileios Kouskouras, Konstantinos Davidhi, Andjoli Papachristodoulou, Angeliki Samaras, Athanasios Giannakoulas, George Ziakas, Antonios Prassopoulos, Panagiotis Karvounis, Haralambos |
author_facet | Rampidis, Georgios Rafailidis, Vasileios Kouskouras, Konstantinos Davidhi, Andjoli Papachristodoulou, Angeliki Samaras, Athanasios Giannakoulas, George Ziakas, Antonios Prassopoulos, Panagiotis Karvounis, Haralambos |
author_sort | Rampidis, Georgios |
collection | PubMed |
description | Coronary artery disease (CAD) represents a modern pandemic associated with significant morbidity and mortality. The multi-faceted pathogenesis of this entity has long been investigated, highlighting the contribution of systemic factors such as hyperlipidemia and hypertension. Nevertheless, recent research has drawn attention to the importance of geometrical features of coronary vasculature on the complexity and vulnerability of coronary atherosclerosis. Various parameters have been investigated so far, including vessel-length, coronary artery volume index, cross-sectional area, curvature, and tortuosity, using primarily invasive coronary angiography (ICA) and recently non-invasive cardiac computed tomography angiography (CCTA). It is clear that there is correlation between geometrical parameters and both the haemodynamic alterations augmenting the atherosclerosis-prone environment and the extent of plaque burden. The purpose of this review is to discuss the currently available literature regarding this issue and propose a potential non-invasive imaging biomarker, the geometric risk score, which could be of importance to allow the early detection of individuals at increased risk of developing CAD. |
format | Online Article Text |
id | pubmed-9497479 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94974792022-09-23 Relationship between Coronary Arterial Geometry and the Presence and Extend of Atherosclerotic Plaque Burden: A Review Discussing Methodology and Findings in the Era of Cardiac Computed Tomography Angiography Rampidis, Georgios Rafailidis, Vasileios Kouskouras, Konstantinos Davidhi, Andjoli Papachristodoulou, Angeliki Samaras, Athanasios Giannakoulas, George Ziakas, Antonios Prassopoulos, Panagiotis Karvounis, Haralambos Diagnostics (Basel) Review Coronary artery disease (CAD) represents a modern pandemic associated with significant morbidity and mortality. The multi-faceted pathogenesis of this entity has long been investigated, highlighting the contribution of systemic factors such as hyperlipidemia and hypertension. Nevertheless, recent research has drawn attention to the importance of geometrical features of coronary vasculature on the complexity and vulnerability of coronary atherosclerosis. Various parameters have been investigated so far, including vessel-length, coronary artery volume index, cross-sectional area, curvature, and tortuosity, using primarily invasive coronary angiography (ICA) and recently non-invasive cardiac computed tomography angiography (CCTA). It is clear that there is correlation between geometrical parameters and both the haemodynamic alterations augmenting the atherosclerosis-prone environment and the extent of plaque burden. The purpose of this review is to discuss the currently available literature regarding this issue and propose a potential non-invasive imaging biomarker, the geometric risk score, which could be of importance to allow the early detection of individuals at increased risk of developing CAD. MDPI 2022-09-09 /pmc/articles/PMC9497479/ /pubmed/36140578 http://dx.doi.org/10.3390/diagnostics12092178 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Rampidis, Georgios Rafailidis, Vasileios Kouskouras, Konstantinos Davidhi, Andjoli Papachristodoulou, Angeliki Samaras, Athanasios Giannakoulas, George Ziakas, Antonios Prassopoulos, Panagiotis Karvounis, Haralambos Relationship between Coronary Arterial Geometry and the Presence and Extend of Atherosclerotic Plaque Burden: A Review Discussing Methodology and Findings in the Era of Cardiac Computed Tomography Angiography |
title | Relationship between Coronary Arterial Geometry and the Presence and Extend of Atherosclerotic Plaque Burden: A Review Discussing Methodology and Findings in the Era of Cardiac Computed Tomography Angiography |
title_full | Relationship between Coronary Arterial Geometry and the Presence and Extend of Atherosclerotic Plaque Burden: A Review Discussing Methodology and Findings in the Era of Cardiac Computed Tomography Angiography |
title_fullStr | Relationship between Coronary Arterial Geometry and the Presence and Extend of Atherosclerotic Plaque Burden: A Review Discussing Methodology and Findings in the Era of Cardiac Computed Tomography Angiography |
title_full_unstemmed | Relationship between Coronary Arterial Geometry and the Presence and Extend of Atherosclerotic Plaque Burden: A Review Discussing Methodology and Findings in the Era of Cardiac Computed Tomography Angiography |
title_short | Relationship between Coronary Arterial Geometry and the Presence and Extend of Atherosclerotic Plaque Burden: A Review Discussing Methodology and Findings in the Era of Cardiac Computed Tomography Angiography |
title_sort | relationship between coronary arterial geometry and the presence and extend of atherosclerotic plaque burden: a review discussing methodology and findings in the era of cardiac computed tomography angiography |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9497479/ https://www.ncbi.nlm.nih.gov/pubmed/36140578 http://dx.doi.org/10.3390/diagnostics12092178 |
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