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The Role of Presepsin in Diagnosing Infections in Patients with Liver Cirrhosis and Overt Hepatic Encephalopathy

Infections and sepsis represent severe liver cirrhosis (LC) complications and the precipitating factors of hepatic encephalopathy (HE). The early diagnosis and treatment of infections in patients with LC and HE can significantly increase their survival. Presepsin is a serum biomarker evaluated for t...

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Autores principales: Igna, Razvan, Gîrleanu, Irina, Cojocariu, Camelia, Muzîca, Cristina, Huiban, Laura, Sfarti, Catalin, Cuciureanu, Tudor, Chiriac, Stefan, Sîngeap, Ana-Maria, Petrea, Oana Cristina, Stafie, Remus, Zenovia, Sebastian, Năstasă, Robert, Stratina, Ermina, Rotaru, Adrian, Stanciu, Carol, Trifan, Anca, Blaj, Mihaela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9497501/
https://www.ncbi.nlm.nih.gov/pubmed/36140479
http://dx.doi.org/10.3390/diagnostics12092077
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author Igna, Razvan
Gîrleanu, Irina
Cojocariu, Camelia
Muzîca, Cristina
Huiban, Laura
Sfarti, Catalin
Cuciureanu, Tudor
Chiriac, Stefan
Sîngeap, Ana-Maria
Petrea, Oana Cristina
Stafie, Remus
Zenovia, Sebastian
Năstasă, Robert
Stratina, Ermina
Rotaru, Adrian
Stanciu, Carol
Trifan, Anca
Blaj, Mihaela
author_facet Igna, Razvan
Gîrleanu, Irina
Cojocariu, Camelia
Muzîca, Cristina
Huiban, Laura
Sfarti, Catalin
Cuciureanu, Tudor
Chiriac, Stefan
Sîngeap, Ana-Maria
Petrea, Oana Cristina
Stafie, Remus
Zenovia, Sebastian
Năstasă, Robert
Stratina, Ermina
Rotaru, Adrian
Stanciu, Carol
Trifan, Anca
Blaj, Mihaela
author_sort Igna, Razvan
collection PubMed
description Infections and sepsis represent severe liver cirrhosis (LC) complications and the precipitating factors of hepatic encephalopathy (HE). The early diagnosis and treatment of infections in patients with LC and HE can significantly increase their survival. Presepsin is a serum biomarker evaluated for the early diagnosis of infections and sepsis in the general and cirrhotic populations. This study aimed to evaluate the role of presepsin in the early diagnosis of infections in patients with LC and HE. This prospective observational study included all consecutive cirrhotic patients admitted to our tertiary university center with overt HE. The patients were follow-up until discharge. In this study, we included 365 patients with a median age of 59 years, of whom 61.9% were male. Infections were diagnosed in 134 patients (36.7%). The presepsin level was higher in patients with infections than those without infections (3167 vs. 500, p < 0.001). The ROC analysis results demonstrated that the best cut-off value for presepsin in infections detection was 980 pg/mL with a sensitivity of 80.17%, specificity of 82.5% (AUROC 0.869, CI 95%: 0.819–0.909, p < 0.001, Youden index J of 0.622), a positive predictive value of 40.63%, and a negative predictive value of 96.53%. In conclusion, in patients with LC and overt HE, presepsin levels >980 pg/mL could enhance the suspicion of bacterial infections. Presepsin may be an adequate non-invasive tool for the early diagnosis of infections in patients with LC and overt HE.
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spelling pubmed-94975012022-09-23 The Role of Presepsin in Diagnosing Infections in Patients with Liver Cirrhosis and Overt Hepatic Encephalopathy Igna, Razvan Gîrleanu, Irina Cojocariu, Camelia Muzîca, Cristina Huiban, Laura Sfarti, Catalin Cuciureanu, Tudor Chiriac, Stefan Sîngeap, Ana-Maria Petrea, Oana Cristina Stafie, Remus Zenovia, Sebastian Năstasă, Robert Stratina, Ermina Rotaru, Adrian Stanciu, Carol Trifan, Anca Blaj, Mihaela Diagnostics (Basel) Article Infections and sepsis represent severe liver cirrhosis (LC) complications and the precipitating factors of hepatic encephalopathy (HE). The early diagnosis and treatment of infections in patients with LC and HE can significantly increase their survival. Presepsin is a serum biomarker evaluated for the early diagnosis of infections and sepsis in the general and cirrhotic populations. This study aimed to evaluate the role of presepsin in the early diagnosis of infections in patients with LC and HE. This prospective observational study included all consecutive cirrhotic patients admitted to our tertiary university center with overt HE. The patients were follow-up until discharge. In this study, we included 365 patients with a median age of 59 years, of whom 61.9% were male. Infections were diagnosed in 134 patients (36.7%). The presepsin level was higher in patients with infections than those without infections (3167 vs. 500, p < 0.001). The ROC analysis results demonstrated that the best cut-off value for presepsin in infections detection was 980 pg/mL with a sensitivity of 80.17%, specificity of 82.5% (AUROC 0.869, CI 95%: 0.819–0.909, p < 0.001, Youden index J of 0.622), a positive predictive value of 40.63%, and a negative predictive value of 96.53%. In conclusion, in patients with LC and overt HE, presepsin levels >980 pg/mL could enhance the suspicion of bacterial infections. Presepsin may be an adequate non-invasive tool for the early diagnosis of infections in patients with LC and overt HE. MDPI 2022-08-27 /pmc/articles/PMC9497501/ /pubmed/36140479 http://dx.doi.org/10.3390/diagnostics12092077 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Igna, Razvan
Gîrleanu, Irina
Cojocariu, Camelia
Muzîca, Cristina
Huiban, Laura
Sfarti, Catalin
Cuciureanu, Tudor
Chiriac, Stefan
Sîngeap, Ana-Maria
Petrea, Oana Cristina
Stafie, Remus
Zenovia, Sebastian
Năstasă, Robert
Stratina, Ermina
Rotaru, Adrian
Stanciu, Carol
Trifan, Anca
Blaj, Mihaela
The Role of Presepsin in Diagnosing Infections in Patients with Liver Cirrhosis and Overt Hepatic Encephalopathy
title The Role of Presepsin in Diagnosing Infections in Patients with Liver Cirrhosis and Overt Hepatic Encephalopathy
title_full The Role of Presepsin in Diagnosing Infections in Patients with Liver Cirrhosis and Overt Hepatic Encephalopathy
title_fullStr The Role of Presepsin in Diagnosing Infections in Patients with Liver Cirrhosis and Overt Hepatic Encephalopathy
title_full_unstemmed The Role of Presepsin in Diagnosing Infections in Patients with Liver Cirrhosis and Overt Hepatic Encephalopathy
title_short The Role of Presepsin in Diagnosing Infections in Patients with Liver Cirrhosis and Overt Hepatic Encephalopathy
title_sort role of presepsin in diagnosing infections in patients with liver cirrhosis and overt hepatic encephalopathy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9497501/
https://www.ncbi.nlm.nih.gov/pubmed/36140479
http://dx.doi.org/10.3390/diagnostics12092077
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