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Synergistic Hypolipidemic Effects and Mechanisms of Phytochemicals: A Review

Hyperlipidemia, a chronic disorder of abnormal lipid metabolism, can induce obesity, diabetes, and cardiovascular and cerebrovascular diseases such as coronary heart disease, atherosclerosis, and hypertension. Increasing evidence indicates that phytochemicals may serve as a promising strategy for th...

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Autores principales: Liu, Yazhou, Liu, Chunlong, Kou, Xiaohong, Wang, Yumeng, Yu, Yue, Zhen, Ni, Jiang, Jingyu, Zhaxi, Puba, Xue, Zhaohui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9497508/
https://www.ncbi.nlm.nih.gov/pubmed/36140902
http://dx.doi.org/10.3390/foods11182774
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author Liu, Yazhou
Liu, Chunlong
Kou, Xiaohong
Wang, Yumeng
Yu, Yue
Zhen, Ni
Jiang, Jingyu
Zhaxi, Puba
Xue, Zhaohui
author_facet Liu, Yazhou
Liu, Chunlong
Kou, Xiaohong
Wang, Yumeng
Yu, Yue
Zhen, Ni
Jiang, Jingyu
Zhaxi, Puba
Xue, Zhaohui
author_sort Liu, Yazhou
collection PubMed
description Hyperlipidemia, a chronic disorder of abnormal lipid metabolism, can induce obesity, diabetes, and cardiovascular and cerebrovascular diseases such as coronary heart disease, atherosclerosis, and hypertension. Increasing evidence indicates that phytochemicals may serve as a promising strategy for the prevention and management of hyperlipidemia and its complications. At the same time, the concept of synergistic hypolipidemic and its application in the food industry is rapidly increasing as a practical approach to preserve and improve the health-promoting effects of functional ingredients. The current review focuses on the effects of single phytochemicals on hyperlipidemia and its mechanisms. Due to the complexity of the lipid metabolism regulatory network, the synergistic regulation of different metabolic pathways or targets may be more effective than single pathways or targets in the treatment of hyperlipidemia. This review summarizes for the first time the synergistic hypolipidemic effects of different combinations of phytochemicals such as combinations of the same category of phytochemicals and combinations of different categories of phytochemicals. In addition, based on the different metabolic pathways or targets involved in synergistic effects, the possible mechanisms of synergistic hypolipidemic effects of the phytochemical combination are illustrated in this review. Hence, this review provides clues to boost more phytochemical synergistic hypolipidemic research and provides a theoretical basis for the development of phytochemicals with synergistic effects on hyperlipidemia and its complications.
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spelling pubmed-94975082022-09-23 Synergistic Hypolipidemic Effects and Mechanisms of Phytochemicals: A Review Liu, Yazhou Liu, Chunlong Kou, Xiaohong Wang, Yumeng Yu, Yue Zhen, Ni Jiang, Jingyu Zhaxi, Puba Xue, Zhaohui Foods Review Hyperlipidemia, a chronic disorder of abnormal lipid metabolism, can induce obesity, diabetes, and cardiovascular and cerebrovascular diseases such as coronary heart disease, atherosclerosis, and hypertension. Increasing evidence indicates that phytochemicals may serve as a promising strategy for the prevention and management of hyperlipidemia and its complications. At the same time, the concept of synergistic hypolipidemic and its application in the food industry is rapidly increasing as a practical approach to preserve and improve the health-promoting effects of functional ingredients. The current review focuses on the effects of single phytochemicals on hyperlipidemia and its mechanisms. Due to the complexity of the lipid metabolism regulatory network, the synergistic regulation of different metabolic pathways or targets may be more effective than single pathways or targets in the treatment of hyperlipidemia. This review summarizes for the first time the synergistic hypolipidemic effects of different combinations of phytochemicals such as combinations of the same category of phytochemicals and combinations of different categories of phytochemicals. In addition, based on the different metabolic pathways or targets involved in synergistic effects, the possible mechanisms of synergistic hypolipidemic effects of the phytochemical combination are illustrated in this review. Hence, this review provides clues to boost more phytochemical synergistic hypolipidemic research and provides a theoretical basis for the development of phytochemicals with synergistic effects on hyperlipidemia and its complications. MDPI 2022-09-09 /pmc/articles/PMC9497508/ /pubmed/36140902 http://dx.doi.org/10.3390/foods11182774 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Liu, Yazhou
Liu, Chunlong
Kou, Xiaohong
Wang, Yumeng
Yu, Yue
Zhen, Ni
Jiang, Jingyu
Zhaxi, Puba
Xue, Zhaohui
Synergistic Hypolipidemic Effects and Mechanisms of Phytochemicals: A Review
title Synergistic Hypolipidemic Effects and Mechanisms of Phytochemicals: A Review
title_full Synergistic Hypolipidemic Effects and Mechanisms of Phytochemicals: A Review
title_fullStr Synergistic Hypolipidemic Effects and Mechanisms of Phytochemicals: A Review
title_full_unstemmed Synergistic Hypolipidemic Effects and Mechanisms of Phytochemicals: A Review
title_short Synergistic Hypolipidemic Effects and Mechanisms of Phytochemicals: A Review
title_sort synergistic hypolipidemic effects and mechanisms of phytochemicals: a review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9497508/
https://www.ncbi.nlm.nih.gov/pubmed/36140902
http://dx.doi.org/10.3390/foods11182774
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