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Inflammation-Related Molecules at the Maternal–Fetal Interface during Pregnancy and in Pathologically Altered Endometrium
The blastocyst expresses paternally derived alloantigens and induces inflammation during implantation. However, it is necessary for the onset of pregnancy. An abnormal response might result in a pathological course of pregnancy or pregnancy failure. On the other hand, a state of maternal immune tole...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9497515/ https://www.ncbi.nlm.nih.gov/pubmed/36135172 http://dx.doi.org/10.3390/cimb44090260 |
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author | Sieg, Wlodzimierz Kiewisz, Jolanta Podolak, Amira Jakiel, Grzegorz Woclawek-Potocka, Izabela Lukaszuk, Jakub Lukaszuk, Krzysztof |
author_facet | Sieg, Wlodzimierz Kiewisz, Jolanta Podolak, Amira Jakiel, Grzegorz Woclawek-Potocka, Izabela Lukaszuk, Jakub Lukaszuk, Krzysztof |
author_sort | Sieg, Wlodzimierz |
collection | PubMed |
description | The blastocyst expresses paternally derived alloantigens and induces inflammation during implantation. However, it is necessary for the onset of pregnancy. An abnormal response might result in a pathological course of pregnancy or pregnancy failure. On the other hand, a state of maternal immune tolerance is necessary to ensure the normal development of pregnancy by suppressing inflammatory processes. This article discusses recognized mechanisms and the significance of inflammatory processes for embryo implantation and pregnancy establishment. We would also like to present disorders involving excessive inflammatory response and their influence on events occurring during embryo implantation. The chain of correlation between the processes responsible for embryo implantation and the subsequent physiological course of pregnancy is complicated. Many of those interrelationships are still yet to be discovered. Undoubtedly, their recognition will give hope to infertile couples for the emergence of new treatments that will increase the chance of giving birth to a healthy child. |
format | Online Article Text |
id | pubmed-9497515 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94975152022-09-23 Inflammation-Related Molecules at the Maternal–Fetal Interface during Pregnancy and in Pathologically Altered Endometrium Sieg, Wlodzimierz Kiewisz, Jolanta Podolak, Amira Jakiel, Grzegorz Woclawek-Potocka, Izabela Lukaszuk, Jakub Lukaszuk, Krzysztof Curr Issues Mol Biol Review The blastocyst expresses paternally derived alloantigens and induces inflammation during implantation. However, it is necessary for the onset of pregnancy. An abnormal response might result in a pathological course of pregnancy or pregnancy failure. On the other hand, a state of maternal immune tolerance is necessary to ensure the normal development of pregnancy by suppressing inflammatory processes. This article discusses recognized mechanisms and the significance of inflammatory processes for embryo implantation and pregnancy establishment. We would also like to present disorders involving excessive inflammatory response and their influence on events occurring during embryo implantation. The chain of correlation between the processes responsible for embryo implantation and the subsequent physiological course of pregnancy is complicated. Many of those interrelationships are still yet to be discovered. Undoubtedly, their recognition will give hope to infertile couples for the emergence of new treatments that will increase the chance of giving birth to a healthy child. MDPI 2022-08-23 /pmc/articles/PMC9497515/ /pubmed/36135172 http://dx.doi.org/10.3390/cimb44090260 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Sieg, Wlodzimierz Kiewisz, Jolanta Podolak, Amira Jakiel, Grzegorz Woclawek-Potocka, Izabela Lukaszuk, Jakub Lukaszuk, Krzysztof Inflammation-Related Molecules at the Maternal–Fetal Interface during Pregnancy and in Pathologically Altered Endometrium |
title | Inflammation-Related Molecules at the Maternal–Fetal Interface during Pregnancy and in Pathologically Altered Endometrium |
title_full | Inflammation-Related Molecules at the Maternal–Fetal Interface during Pregnancy and in Pathologically Altered Endometrium |
title_fullStr | Inflammation-Related Molecules at the Maternal–Fetal Interface during Pregnancy and in Pathologically Altered Endometrium |
title_full_unstemmed | Inflammation-Related Molecules at the Maternal–Fetal Interface during Pregnancy and in Pathologically Altered Endometrium |
title_short | Inflammation-Related Molecules at the Maternal–Fetal Interface during Pregnancy and in Pathologically Altered Endometrium |
title_sort | inflammation-related molecules at the maternal–fetal interface during pregnancy and in pathologically altered endometrium |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9497515/ https://www.ncbi.nlm.nih.gov/pubmed/36135172 http://dx.doi.org/10.3390/cimb44090260 |
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