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The Diagnostic Value of PI-RADS v2.1 in Patients with a History of Transurethral Resection of the Prostate (TURP)

To explore the diagnostic value of the Prostate Imaging–Reporting and Data System version 2.1 (PI-RADS v2.1) for clinically significant prostate cancer (CSPCa) in patients with a history of transurethral resection of the prostate (TURP), we conducted a retrospective study of 102 patients who underwe...

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Autores principales: Liu, Jiazhou, Pan, Shihang, Dong, Liang, Wu, Guangyu, Wang, Jiayi, Wang, Yan, Qian, Hongyang, Dong, Baijun, Pan, Jiahua, Zhu, Yinjie, Xue, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9497547/
https://www.ncbi.nlm.nih.gov/pubmed/36135071
http://dx.doi.org/10.3390/curroncol29090502
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author Liu, Jiazhou
Pan, Shihang
Dong, Liang
Wu, Guangyu
Wang, Jiayi
Wang, Yan
Qian, Hongyang
Dong, Baijun
Pan, Jiahua
Zhu, Yinjie
Xue, Wei
author_facet Liu, Jiazhou
Pan, Shihang
Dong, Liang
Wu, Guangyu
Wang, Jiayi
Wang, Yan
Qian, Hongyang
Dong, Baijun
Pan, Jiahua
Zhu, Yinjie
Xue, Wei
author_sort Liu, Jiazhou
collection PubMed
description To explore the diagnostic value of the Prostate Imaging–Reporting and Data System version 2.1 (PI-RADS v2.1) for clinically significant prostate cancer (CSPCa) in patients with a history of transurethral resection of the prostate (TURP), we conducted a retrospective study of 102 patients who underwent systematic prostate biopsies with TURP history. ROC analyses and logistic regression analyses were performed to demonstrate the diagnostic value of PI-RADS v2.1 and other clinical characteristics, including PSA and free/total PSA (F/T PSA). Of 102 patients, 43 were diagnosed with CSPCa. In ROC analysis, PSA, F/T PSA, and PI-RADS v2.1 demonstrated significant diagnostic value in detecting CSPCa in our cohort (AUC 0.710 (95%CI 0.608–0.812), AUC 0.768 (95%CI 0.676–0.860), AUC 0.777 (95%CI 0.688–0.867), respectively). Further, PI-RADS v2.1 scores of the peripheral and transitional zones were analyzed separately. In ROC analysis, PI-RADS v2.1 remained valuable in identifying peripheral-zone CSPCa (AUC 0.780 (95%CI 0.665–0.854; p < 0.001)) while having limited capability in distinguishing transitional zone lesions (AUC 0.533 (95%CI 0.410–0.557; p = 0.594)). PSA and F/T PSA retain significant diagnostic value for CSPCa in patients with TURP history. PI-RADS v2.1 is reliable for detecting peripheral-zone CSPCa but has limited diagnostic value when assessing transitional zone lesions.
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spelling pubmed-94975472022-09-23 The Diagnostic Value of PI-RADS v2.1 in Patients with a History of Transurethral Resection of the Prostate (TURP) Liu, Jiazhou Pan, Shihang Dong, Liang Wu, Guangyu Wang, Jiayi Wang, Yan Qian, Hongyang Dong, Baijun Pan, Jiahua Zhu, Yinjie Xue, Wei Curr Oncol Article To explore the diagnostic value of the Prostate Imaging–Reporting and Data System version 2.1 (PI-RADS v2.1) for clinically significant prostate cancer (CSPCa) in patients with a history of transurethral resection of the prostate (TURP), we conducted a retrospective study of 102 patients who underwent systematic prostate biopsies with TURP history. ROC analyses and logistic regression analyses were performed to demonstrate the diagnostic value of PI-RADS v2.1 and other clinical characteristics, including PSA and free/total PSA (F/T PSA). Of 102 patients, 43 were diagnosed with CSPCa. In ROC analysis, PSA, F/T PSA, and PI-RADS v2.1 demonstrated significant diagnostic value in detecting CSPCa in our cohort (AUC 0.710 (95%CI 0.608–0.812), AUC 0.768 (95%CI 0.676–0.860), AUC 0.777 (95%CI 0.688–0.867), respectively). Further, PI-RADS v2.1 scores of the peripheral and transitional zones were analyzed separately. In ROC analysis, PI-RADS v2.1 remained valuable in identifying peripheral-zone CSPCa (AUC 0.780 (95%CI 0.665–0.854; p < 0.001)) while having limited capability in distinguishing transitional zone lesions (AUC 0.533 (95%CI 0.410–0.557; p = 0.594)). PSA and F/T PSA retain significant diagnostic value for CSPCa in patients with TURP history. PI-RADS v2.1 is reliable for detecting peripheral-zone CSPCa but has limited diagnostic value when assessing transitional zone lesions. MDPI 2022-09-05 /pmc/articles/PMC9497547/ /pubmed/36135071 http://dx.doi.org/10.3390/curroncol29090502 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Liu, Jiazhou
Pan, Shihang
Dong, Liang
Wu, Guangyu
Wang, Jiayi
Wang, Yan
Qian, Hongyang
Dong, Baijun
Pan, Jiahua
Zhu, Yinjie
Xue, Wei
The Diagnostic Value of PI-RADS v2.1 in Patients with a History of Transurethral Resection of the Prostate (TURP)
title The Diagnostic Value of PI-RADS v2.1 in Patients with a History of Transurethral Resection of the Prostate (TURP)
title_full The Diagnostic Value of PI-RADS v2.1 in Patients with a History of Transurethral Resection of the Prostate (TURP)
title_fullStr The Diagnostic Value of PI-RADS v2.1 in Patients with a History of Transurethral Resection of the Prostate (TURP)
title_full_unstemmed The Diagnostic Value of PI-RADS v2.1 in Patients with a History of Transurethral Resection of the Prostate (TURP)
title_short The Diagnostic Value of PI-RADS v2.1 in Patients with a History of Transurethral Resection of the Prostate (TURP)
title_sort diagnostic value of pi-rads v2.1 in patients with a history of transurethral resection of the prostate (turp)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9497547/
https://www.ncbi.nlm.nih.gov/pubmed/36135071
http://dx.doi.org/10.3390/curroncol29090502
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