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Optical Coherence Tomography Significance in Managing Early Onset of Optic Pathway Gliomas in Children Younger than 5 Years of Age—A Retrospective Study

We aimed to investigate the significance of optical coherence tomography (SD-OCT) in managing pediatric optic pathway gliomas (OPGs) in children younger than 5 years of age. A retrospective monocentric study was conducted. SD-OCT scans were obtained using the handheld iVue system to assess peripapil...

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Autores principales: Pavone, Rossana, Fonte, Carla, Sardi, Iacopo, Caputo, Roberto, Marziali, Elisa, Mazzeo, Fabio, Secci, Jacopo, Bergamini, Alessia, De Masi, Salvatore, Leo, Maria Carmela, Censullo, Maria Luigia, Bacci, Giacomo Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9497564/
https://www.ncbi.nlm.nih.gov/pubmed/36138616
http://dx.doi.org/10.3390/children9091307
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author Pavone, Rossana
Fonte, Carla
Sardi, Iacopo
Caputo, Roberto
Marziali, Elisa
Mazzeo, Fabio
Secci, Jacopo
Bergamini, Alessia
De Masi, Salvatore
Leo, Maria Carmela
Censullo, Maria Luigia
Bacci, Giacomo Maria
author_facet Pavone, Rossana
Fonte, Carla
Sardi, Iacopo
Caputo, Roberto
Marziali, Elisa
Mazzeo, Fabio
Secci, Jacopo
Bergamini, Alessia
De Masi, Salvatore
Leo, Maria Carmela
Censullo, Maria Luigia
Bacci, Giacomo Maria
author_sort Pavone, Rossana
collection PubMed
description We aimed to investigate the significance of optical coherence tomography (SD-OCT) in managing pediatric optic pathway gliomas (OPGs) in children younger than 5 years of age. A retrospective monocentric study was conducted. SD-OCT scans were obtained using the handheld iVue system to assess peripapillary retinal nerve fibre layer (pRNFL) thickness at three time points: baseline (OCT1), end of treatment (OCT2), and at last follow-up (OCT3). We compared the median value of pRNFL (and interquartile range—IQR) at different follow-up times and in different sub-groups (stable disease—SD, partial response—PR, and progression disease—PD). Thirteen children younger than 5 years of age were included. The Median follow-up time was 3.9 years (IQR 1.2). Six patients showed a pRNFL change of more than 10% during follow-up. Seven patients showed PD during follow-up. Median pRNFL at baseline was 81.5 µm (IQR 31.5); median pRNFL at the end of treatment was 73 µm (IQR 33); median pRNFL at last follow-up was 72 µm (IQR 38.5). The mean pRNFL at baseline was significantly lower than the mean normative values. Only subjects with PD showed pRNFL change close to statistical significance. This study confirms the role of SD-OCT in managing OPGs for therapeutic decisions and strategy planning of visual rehabilitation.
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spelling pubmed-94975642022-09-23 Optical Coherence Tomography Significance in Managing Early Onset of Optic Pathway Gliomas in Children Younger than 5 Years of Age—A Retrospective Study Pavone, Rossana Fonte, Carla Sardi, Iacopo Caputo, Roberto Marziali, Elisa Mazzeo, Fabio Secci, Jacopo Bergamini, Alessia De Masi, Salvatore Leo, Maria Carmela Censullo, Maria Luigia Bacci, Giacomo Maria Children (Basel) Article We aimed to investigate the significance of optical coherence tomography (SD-OCT) in managing pediatric optic pathway gliomas (OPGs) in children younger than 5 years of age. A retrospective monocentric study was conducted. SD-OCT scans were obtained using the handheld iVue system to assess peripapillary retinal nerve fibre layer (pRNFL) thickness at three time points: baseline (OCT1), end of treatment (OCT2), and at last follow-up (OCT3). We compared the median value of pRNFL (and interquartile range—IQR) at different follow-up times and in different sub-groups (stable disease—SD, partial response—PR, and progression disease—PD). Thirteen children younger than 5 years of age were included. The Median follow-up time was 3.9 years (IQR 1.2). Six patients showed a pRNFL change of more than 10% during follow-up. Seven patients showed PD during follow-up. Median pRNFL at baseline was 81.5 µm (IQR 31.5); median pRNFL at the end of treatment was 73 µm (IQR 33); median pRNFL at last follow-up was 72 µm (IQR 38.5). The mean pRNFL at baseline was significantly lower than the mean normative values. Only subjects with PD showed pRNFL change close to statistical significance. This study confirms the role of SD-OCT in managing OPGs for therapeutic decisions and strategy planning of visual rehabilitation. MDPI 2022-08-28 /pmc/articles/PMC9497564/ /pubmed/36138616 http://dx.doi.org/10.3390/children9091307 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Pavone, Rossana
Fonte, Carla
Sardi, Iacopo
Caputo, Roberto
Marziali, Elisa
Mazzeo, Fabio
Secci, Jacopo
Bergamini, Alessia
De Masi, Salvatore
Leo, Maria Carmela
Censullo, Maria Luigia
Bacci, Giacomo Maria
Optical Coherence Tomography Significance in Managing Early Onset of Optic Pathway Gliomas in Children Younger than 5 Years of Age—A Retrospective Study
title Optical Coherence Tomography Significance in Managing Early Onset of Optic Pathway Gliomas in Children Younger than 5 Years of Age—A Retrospective Study
title_full Optical Coherence Tomography Significance in Managing Early Onset of Optic Pathway Gliomas in Children Younger than 5 Years of Age—A Retrospective Study
title_fullStr Optical Coherence Tomography Significance in Managing Early Onset of Optic Pathway Gliomas in Children Younger than 5 Years of Age—A Retrospective Study
title_full_unstemmed Optical Coherence Tomography Significance in Managing Early Onset of Optic Pathway Gliomas in Children Younger than 5 Years of Age—A Retrospective Study
title_short Optical Coherence Tomography Significance in Managing Early Onset of Optic Pathway Gliomas in Children Younger than 5 Years of Age—A Retrospective Study
title_sort optical coherence tomography significance in managing early onset of optic pathway gliomas in children younger than 5 years of age—a retrospective study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9497564/
https://www.ncbi.nlm.nih.gov/pubmed/36138616
http://dx.doi.org/10.3390/children9091307
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