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The Association of Organ Preservation Fluid Pathogens with Early Infection-Related Events after Kidney Transplantation

(1) Background: The need to elucidate the microbial patterns in preservation fluid and explore their relationship with early infection-related events post kidney transplant and investigate antimicrobial resistance and the effects of preemptive antibiotic therapy. (2) Methods: This retrospective stud...

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Autores principales: Li, Jianming, Su, Xiaojun, Li, Jianyi, Wu, Wenrui, Wu, Chenglin, Guo, Penghao, Liao, Kang, Fu, Qian, Li, Jun, Liu, Longshan, Wang, Changxi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9497690/
https://www.ncbi.nlm.nih.gov/pubmed/36140649
http://dx.doi.org/10.3390/diagnostics12092248
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author Li, Jianming
Su, Xiaojun
Li, Jianyi
Wu, Wenrui
Wu, Chenglin
Guo, Penghao
Liao, Kang
Fu, Qian
Li, Jun
Liu, Longshan
Wang, Changxi
author_facet Li, Jianming
Su, Xiaojun
Li, Jianyi
Wu, Wenrui
Wu, Chenglin
Guo, Penghao
Liao, Kang
Fu, Qian
Li, Jun
Liu, Longshan
Wang, Changxi
author_sort Li, Jianming
collection PubMed
description (1) Background: The need to elucidate the microbial patterns in preservation fluid and explore their relationship with early infection-related events post kidney transplant and investigate antimicrobial resistance and the effects of preemptive antibiotic therapy. (2) Methods: This retrospective study analyzed the clinical data of 514 kidney transplant donors and 808 recipients from April 2015 to October 2020. Clinical data of donor and recipient characteristics, preservation fluid microbes, early infections (≤30 days), probable donor-derived infections (P-DDIs), antimicrobial resistance and preemptive antibiotic therapy was collected. (3) Results: The incidence of bloodstream (10.3% versus 5.2%, p = 0.006) and graft-site infections (9.7% versus 4.6%, p = 0.004) was significantly higher in recipients with culture-positive preservation fluid. In addition, recipients with ESKAPE pathogens or Candida species had a notably higher rate of bloodstream infections (14.1% versus 6.9%, p = 0.033) and graft-site infections (16.7% versus 3.5%, p < 0.01) than those with other positive pathogens. Preemptive antibiotic therapy decreased the bloodstream infection rate (11.8% versus 35.7%, p = 0.047) when preservation fluid was positive for ESKAPE pathogens. (4) Conclusions: Culture-positive preservation fluid has potential implications for kidney transplant recipients. ESKAPE pathogens or Candida species in preservation fluid as well as their antimicrobial resistance properties and non-preemptive antibiotic therapy could pose a risk of early infection-related events.
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spelling pubmed-94976902022-09-23 The Association of Organ Preservation Fluid Pathogens with Early Infection-Related Events after Kidney Transplantation Li, Jianming Su, Xiaojun Li, Jianyi Wu, Wenrui Wu, Chenglin Guo, Penghao Liao, Kang Fu, Qian Li, Jun Liu, Longshan Wang, Changxi Diagnostics (Basel) Article (1) Background: The need to elucidate the microbial patterns in preservation fluid and explore their relationship with early infection-related events post kidney transplant and investigate antimicrobial resistance and the effects of preemptive antibiotic therapy. (2) Methods: This retrospective study analyzed the clinical data of 514 kidney transplant donors and 808 recipients from April 2015 to October 2020. Clinical data of donor and recipient characteristics, preservation fluid microbes, early infections (≤30 days), probable donor-derived infections (P-DDIs), antimicrobial resistance and preemptive antibiotic therapy was collected. (3) Results: The incidence of bloodstream (10.3% versus 5.2%, p = 0.006) and graft-site infections (9.7% versus 4.6%, p = 0.004) was significantly higher in recipients with culture-positive preservation fluid. In addition, recipients with ESKAPE pathogens or Candida species had a notably higher rate of bloodstream infections (14.1% versus 6.9%, p = 0.033) and graft-site infections (16.7% versus 3.5%, p < 0.01) than those with other positive pathogens. Preemptive antibiotic therapy decreased the bloodstream infection rate (11.8% versus 35.7%, p = 0.047) when preservation fluid was positive for ESKAPE pathogens. (4) Conclusions: Culture-positive preservation fluid has potential implications for kidney transplant recipients. ESKAPE pathogens or Candida species in preservation fluid as well as their antimicrobial resistance properties and non-preemptive antibiotic therapy could pose a risk of early infection-related events. MDPI 2022-09-18 /pmc/articles/PMC9497690/ /pubmed/36140649 http://dx.doi.org/10.3390/diagnostics12092248 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Li, Jianming
Su, Xiaojun
Li, Jianyi
Wu, Wenrui
Wu, Chenglin
Guo, Penghao
Liao, Kang
Fu, Qian
Li, Jun
Liu, Longshan
Wang, Changxi
The Association of Organ Preservation Fluid Pathogens with Early Infection-Related Events after Kidney Transplantation
title The Association of Organ Preservation Fluid Pathogens with Early Infection-Related Events after Kidney Transplantation
title_full The Association of Organ Preservation Fluid Pathogens with Early Infection-Related Events after Kidney Transplantation
title_fullStr The Association of Organ Preservation Fluid Pathogens with Early Infection-Related Events after Kidney Transplantation
title_full_unstemmed The Association of Organ Preservation Fluid Pathogens with Early Infection-Related Events after Kidney Transplantation
title_short The Association of Organ Preservation Fluid Pathogens with Early Infection-Related Events after Kidney Transplantation
title_sort association of organ preservation fluid pathogens with early infection-related events after kidney transplantation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9497690/
https://www.ncbi.nlm.nih.gov/pubmed/36140649
http://dx.doi.org/10.3390/diagnostics12092248
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