Different Uptake of (68)Ga-FAPI and (18)F-FDG in Lymphadenopathy Caused by Angioimmunoblastic T-Cell Lymphoma in a Patient with Colon Cancer

An 82-year-old man with a history of colon cancer was found with multiple lymphadenopathies and a pulmonary mass. Fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) detected generalized hypermetabolic lymph nodes and an FDG-avid pulmonary mass. PET/CT...

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Autores principales: Wu, Meiqi, Pan, Qingqing, Luo, Yaping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9497719/
https://www.ncbi.nlm.nih.gov/pubmed/36140612
http://dx.doi.org/10.3390/diagnostics12092211
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author Wu, Meiqi
Pan, Qingqing
Luo, Yaping
author_facet Wu, Meiqi
Pan, Qingqing
Luo, Yaping
author_sort Wu, Meiqi
collection PubMed
description An 82-year-old man with a history of colon cancer was found with multiple lymphadenopathies and a pulmonary mass. Fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) detected generalized hypermetabolic lymph nodes and an FDG-avid pulmonary mass. PET/CT with (68)Ga-labeled fibroblast activation protein inhibitor (FAPI) revealed intense uptake in the lung mass, consistent with metastatic disease from colon cancer. However, the lymphadenopathies were not avid for (68)Ga-FAPI, suggesting a different etiology. The biopsy of a cervical node confirmed angioimmunoblastic T-cell lymphoma. The case showcased the potential of (68)Ga-FAPI in differentiation of solid tumor and hematological disease due to different histopathologic nature of stromal fibrosis.
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spelling pubmed-94977192022-09-23 Different Uptake of (68)Ga-FAPI and (18)F-FDG in Lymphadenopathy Caused by Angioimmunoblastic T-Cell Lymphoma in a Patient with Colon Cancer Wu, Meiqi Pan, Qingqing Luo, Yaping Diagnostics (Basel) Interesting Images An 82-year-old man with a history of colon cancer was found with multiple lymphadenopathies and a pulmonary mass. Fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) detected generalized hypermetabolic lymph nodes and an FDG-avid pulmonary mass. PET/CT with (68)Ga-labeled fibroblast activation protein inhibitor (FAPI) revealed intense uptake in the lung mass, consistent with metastatic disease from colon cancer. However, the lymphadenopathies were not avid for (68)Ga-FAPI, suggesting a different etiology. The biopsy of a cervical node confirmed angioimmunoblastic T-cell lymphoma. The case showcased the potential of (68)Ga-FAPI in differentiation of solid tumor and hematological disease due to different histopathologic nature of stromal fibrosis. MDPI 2022-09-13 /pmc/articles/PMC9497719/ /pubmed/36140612 http://dx.doi.org/10.3390/diagnostics12092211 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Interesting Images
Wu, Meiqi
Pan, Qingqing
Luo, Yaping
Different Uptake of (68)Ga-FAPI and (18)F-FDG in Lymphadenopathy Caused by Angioimmunoblastic T-Cell Lymphoma in a Patient with Colon Cancer
title Different Uptake of (68)Ga-FAPI and (18)F-FDG in Lymphadenopathy Caused by Angioimmunoblastic T-Cell Lymphoma in a Patient with Colon Cancer
title_full Different Uptake of (68)Ga-FAPI and (18)F-FDG in Lymphadenopathy Caused by Angioimmunoblastic T-Cell Lymphoma in a Patient with Colon Cancer
title_fullStr Different Uptake of (68)Ga-FAPI and (18)F-FDG in Lymphadenopathy Caused by Angioimmunoblastic T-Cell Lymphoma in a Patient with Colon Cancer
title_full_unstemmed Different Uptake of (68)Ga-FAPI and (18)F-FDG in Lymphadenopathy Caused by Angioimmunoblastic T-Cell Lymphoma in a Patient with Colon Cancer
title_short Different Uptake of (68)Ga-FAPI and (18)F-FDG in Lymphadenopathy Caused by Angioimmunoblastic T-Cell Lymphoma in a Patient with Colon Cancer
title_sort different uptake of (68)ga-fapi and (18)f-fdg in lymphadenopathy caused by angioimmunoblastic t-cell lymphoma in a patient with colon cancer
topic Interesting Images
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9497719/
https://www.ncbi.nlm.nih.gov/pubmed/36140612
http://dx.doi.org/10.3390/diagnostics12092211
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AT luoyaping differentuptakeof68gafapiand18ffdginlymphadenopathycausedbyangioimmunoblastictcelllymphomainapatientwithcoloncancer

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