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Trends in Infectious Keratitis in Taiwan: An Update on Predisposing Factors, Microbiological and Antibiotic Susceptibility Patterns

Infectious keratitis (IK) represents a major cause of corneal blindness. This study aims to investigate the demographics, risk factors, microbiological characteristics and antibiotic susceptibility patterns of IK in Taiwan over the past 15 years. A retrospective population-based study was conducted...

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Autores principales: Wang, Jin-Jhe, Lai, Chien-Hsiung, Chen, Chau-Yin, Liu, Chia-Yen, Lin, Meng-Hung, Yang, Yao-Hsu, Wu, Pei-Lun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9497811/
https://www.ncbi.nlm.nih.gov/pubmed/36140496
http://dx.doi.org/10.3390/diagnostics12092095
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author Wang, Jin-Jhe
Lai, Chien-Hsiung
Chen, Chau-Yin
Liu, Chia-Yen
Lin, Meng-Hung
Yang, Yao-Hsu
Wu, Pei-Lun
author_facet Wang, Jin-Jhe
Lai, Chien-Hsiung
Chen, Chau-Yin
Liu, Chia-Yen
Lin, Meng-Hung
Yang, Yao-Hsu
Wu, Pei-Lun
author_sort Wang, Jin-Jhe
collection PubMed
description Infectious keratitis (IK) represents a major cause of corneal blindness. This study aims to investigate the demographics, risk factors, microbiological characteristics and antibiotic susceptibility patterns of IK in Taiwan over the past 15 years. A retrospective population-based study was conducted using the Chang Gung Research Database. Patients with IK were identified by diagnostic codes for corneal ulcer from 2004 to 2019. Of 7807 included subjects, 45.2% of patients had positive corneal cultures. The proportion of contact lens-related IK declined, while that of IK related to systemic diseases grew. The percentage of isolated gram-positive bacteria surpassed that of gram-negative bacteria in the 15-year period. The prevalence of Pseudomonas aeruginosa showed a decreasing trend (p = 0.004), whereas coagulase-negative Staphylococcus (CNS) and Propionibacterium species were increasingly detected (p < 0.001). Overall, the trend of antibiotic susceptibility of both gram-positive and gram-negative bacteria did not change throughout the study period. The susceptibility to the test antibiotics maintained over 90% in gram-negative isolates over 15 years. Vancomycin preserved 100% susceptibility to all gram-positive isolates. Since most tested antibiotics exhibited stable susceptibility over decades, this study reinforced that fluoroquinolones and fortified vancomycin continue to be good empiric therapies for treating bacterial keratitis in Taiwan.
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spelling pubmed-94978112022-09-23 Trends in Infectious Keratitis in Taiwan: An Update on Predisposing Factors, Microbiological and Antibiotic Susceptibility Patterns Wang, Jin-Jhe Lai, Chien-Hsiung Chen, Chau-Yin Liu, Chia-Yen Lin, Meng-Hung Yang, Yao-Hsu Wu, Pei-Lun Diagnostics (Basel) Article Infectious keratitis (IK) represents a major cause of corneal blindness. This study aims to investigate the demographics, risk factors, microbiological characteristics and antibiotic susceptibility patterns of IK in Taiwan over the past 15 years. A retrospective population-based study was conducted using the Chang Gung Research Database. Patients with IK were identified by diagnostic codes for corneal ulcer from 2004 to 2019. Of 7807 included subjects, 45.2% of patients had positive corneal cultures. The proportion of contact lens-related IK declined, while that of IK related to systemic diseases grew. The percentage of isolated gram-positive bacteria surpassed that of gram-negative bacteria in the 15-year period. The prevalence of Pseudomonas aeruginosa showed a decreasing trend (p = 0.004), whereas coagulase-negative Staphylococcus (CNS) and Propionibacterium species were increasingly detected (p < 0.001). Overall, the trend of antibiotic susceptibility of both gram-positive and gram-negative bacteria did not change throughout the study period. The susceptibility to the test antibiotics maintained over 90% in gram-negative isolates over 15 years. Vancomycin preserved 100% susceptibility to all gram-positive isolates. Since most tested antibiotics exhibited stable susceptibility over decades, this study reinforced that fluoroquinolones and fortified vancomycin continue to be good empiric therapies for treating bacterial keratitis in Taiwan. MDPI 2022-08-29 /pmc/articles/PMC9497811/ /pubmed/36140496 http://dx.doi.org/10.3390/diagnostics12092095 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wang, Jin-Jhe
Lai, Chien-Hsiung
Chen, Chau-Yin
Liu, Chia-Yen
Lin, Meng-Hung
Yang, Yao-Hsu
Wu, Pei-Lun
Trends in Infectious Keratitis in Taiwan: An Update on Predisposing Factors, Microbiological and Antibiotic Susceptibility Patterns
title Trends in Infectious Keratitis in Taiwan: An Update on Predisposing Factors, Microbiological and Antibiotic Susceptibility Patterns
title_full Trends in Infectious Keratitis in Taiwan: An Update on Predisposing Factors, Microbiological and Antibiotic Susceptibility Patterns
title_fullStr Trends in Infectious Keratitis in Taiwan: An Update on Predisposing Factors, Microbiological and Antibiotic Susceptibility Patterns
title_full_unstemmed Trends in Infectious Keratitis in Taiwan: An Update on Predisposing Factors, Microbiological and Antibiotic Susceptibility Patterns
title_short Trends in Infectious Keratitis in Taiwan: An Update on Predisposing Factors, Microbiological and Antibiotic Susceptibility Patterns
title_sort trends in infectious keratitis in taiwan: an update on predisposing factors, microbiological and antibiotic susceptibility patterns
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9497811/
https://www.ncbi.nlm.nih.gov/pubmed/36140496
http://dx.doi.org/10.3390/diagnostics12092095
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