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Long-Term Survival after Linac-Based Stereotactic Radiosurgery and Radiotherapy with a Micro-Multileaf Collimator for Brain Metastasis

Background: this study aimed to evaluate the prognostic factors associated with long-term survival after linear accelerator (linac)-based stereotactic radiosurgery (SRS) and fractionated stereotactic radiotherapy (fSRT) with a micro-multileaf collimator for brain metastasis (BM). Methods: This singl...

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Autores principales: Matsuda, Ryosuke, Hasegawa, Masatoshi, Tamamoto, Tetsuro, Inooka, Nobuyoshi, Nikimoto, Mei, Ochi, Tomoko, Miyasaka, Toshiteru, Hontsu, Shigeto, Yamaki, Kaori, Miura, Sachiko, Morimoto, Takayuki, Mitsui, Takaaki, Furuta, Takanori, Yokoyama, Shohei, Kotsugi, Masashi, Yamada, Shuichi, Nakagawa, Ichiro, Park, Young-Soo, Nakase, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9497847/
https://www.ncbi.nlm.nih.gov/pubmed/36135046
http://dx.doi.org/10.3390/curroncol29090477
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author Matsuda, Ryosuke
Hasegawa, Masatoshi
Tamamoto, Tetsuro
Inooka, Nobuyoshi
Nikimoto, Mei
Ochi, Tomoko
Miyasaka, Toshiteru
Hontsu, Shigeto
Yamaki, Kaori
Miura, Sachiko
Morimoto, Takayuki
Mitsui, Takaaki
Furuta, Takanori
Yokoyama, Shohei
Kotsugi, Masashi
Yamada, Shuichi
Nakagawa, Ichiro
Park, Young-Soo
Nakase, Hiroyuki
author_facet Matsuda, Ryosuke
Hasegawa, Masatoshi
Tamamoto, Tetsuro
Inooka, Nobuyoshi
Nikimoto, Mei
Ochi, Tomoko
Miyasaka, Toshiteru
Hontsu, Shigeto
Yamaki, Kaori
Miura, Sachiko
Morimoto, Takayuki
Mitsui, Takaaki
Furuta, Takanori
Yokoyama, Shohei
Kotsugi, Masashi
Yamada, Shuichi
Nakagawa, Ichiro
Park, Young-Soo
Nakase, Hiroyuki
author_sort Matsuda, Ryosuke
collection PubMed
description Background: this study aimed to evaluate the prognostic factors associated with long-term survival after linear accelerator (linac)-based stereotactic radiosurgery (SRS) and fractionated stereotactic radiotherapy (fSRT) with a micro-multileaf collimator for brain metastasis (BM). Methods: This single-center retrospective study included 226 consecutive patients with BM who were treated with linac-based SRS or fSRT with a micro-multileaf collimator between January 2011 and December 2018. Long-term survival (LTS) was defined as survival for more than 2 years after SRS/fSRT. Results: The tumors originated from the lung (n = 189, 83.6%), breast (n = 11, 4.9%), colon (n = 9, 4.0%), stomach (n = 4, 1.8%), kidney (n = 3, 1.3%), esophagus (n = 3, 1.3%), and other regions (n = 7, 3.1%). The median pretreatment Karnofsky performance scale (KPS) score was 90 (range: 40–100). The median follow-up time was 13 (range: 0–120) months. Out of the 226 patients, 72 (31.8%) were categorized in the LTS group. The median survival time was 43 months and 13 months in the LTS group and in the entire cohort, respectively. The 3-year, 4-year, and 5-year survival rate in the LTS group was 59.1%, 49.6%, and 40.7%, respectively. Multivariate regression logistic analysis showed that female sex, a pre-treatment KPS score ≥ 80, and the absence of extracranial metastasis were associated with long-term survival. Conclusions: female sex, a favorable pre-treatment KPS score, and the absence of extracranial metastasis were associated with long-term survival in the current cohort of patients with BM.
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spelling pubmed-94978472022-09-23 Long-Term Survival after Linac-Based Stereotactic Radiosurgery and Radiotherapy with a Micro-Multileaf Collimator for Brain Metastasis Matsuda, Ryosuke Hasegawa, Masatoshi Tamamoto, Tetsuro Inooka, Nobuyoshi Nikimoto, Mei Ochi, Tomoko Miyasaka, Toshiteru Hontsu, Shigeto Yamaki, Kaori Miura, Sachiko Morimoto, Takayuki Mitsui, Takaaki Furuta, Takanori Yokoyama, Shohei Kotsugi, Masashi Yamada, Shuichi Nakagawa, Ichiro Park, Young-Soo Nakase, Hiroyuki Curr Oncol Article Background: this study aimed to evaluate the prognostic factors associated with long-term survival after linear accelerator (linac)-based stereotactic radiosurgery (SRS) and fractionated stereotactic radiotherapy (fSRT) with a micro-multileaf collimator for brain metastasis (BM). Methods: This single-center retrospective study included 226 consecutive patients with BM who were treated with linac-based SRS or fSRT with a micro-multileaf collimator between January 2011 and December 2018. Long-term survival (LTS) was defined as survival for more than 2 years after SRS/fSRT. Results: The tumors originated from the lung (n = 189, 83.6%), breast (n = 11, 4.9%), colon (n = 9, 4.0%), stomach (n = 4, 1.8%), kidney (n = 3, 1.3%), esophagus (n = 3, 1.3%), and other regions (n = 7, 3.1%). The median pretreatment Karnofsky performance scale (KPS) score was 90 (range: 40–100). The median follow-up time was 13 (range: 0–120) months. Out of the 226 patients, 72 (31.8%) were categorized in the LTS group. The median survival time was 43 months and 13 months in the LTS group and in the entire cohort, respectively. The 3-year, 4-year, and 5-year survival rate in the LTS group was 59.1%, 49.6%, and 40.7%, respectively. Multivariate regression logistic analysis showed that female sex, a pre-treatment KPS score ≥ 80, and the absence of extracranial metastasis were associated with long-term survival. Conclusions: female sex, a favorable pre-treatment KPS score, and the absence of extracranial metastasis were associated with long-term survival in the current cohort of patients with BM. MDPI 2022-08-24 /pmc/articles/PMC9497847/ /pubmed/36135046 http://dx.doi.org/10.3390/curroncol29090477 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Matsuda, Ryosuke
Hasegawa, Masatoshi
Tamamoto, Tetsuro
Inooka, Nobuyoshi
Nikimoto, Mei
Ochi, Tomoko
Miyasaka, Toshiteru
Hontsu, Shigeto
Yamaki, Kaori
Miura, Sachiko
Morimoto, Takayuki
Mitsui, Takaaki
Furuta, Takanori
Yokoyama, Shohei
Kotsugi, Masashi
Yamada, Shuichi
Nakagawa, Ichiro
Park, Young-Soo
Nakase, Hiroyuki
Long-Term Survival after Linac-Based Stereotactic Radiosurgery and Radiotherapy with a Micro-Multileaf Collimator for Brain Metastasis
title Long-Term Survival after Linac-Based Stereotactic Radiosurgery and Radiotherapy with a Micro-Multileaf Collimator for Brain Metastasis
title_full Long-Term Survival after Linac-Based Stereotactic Radiosurgery and Radiotherapy with a Micro-Multileaf Collimator for Brain Metastasis
title_fullStr Long-Term Survival after Linac-Based Stereotactic Radiosurgery and Radiotherapy with a Micro-Multileaf Collimator for Brain Metastasis
title_full_unstemmed Long-Term Survival after Linac-Based Stereotactic Radiosurgery and Radiotherapy with a Micro-Multileaf Collimator for Brain Metastasis
title_short Long-Term Survival after Linac-Based Stereotactic Radiosurgery and Radiotherapy with a Micro-Multileaf Collimator for Brain Metastasis
title_sort long-term survival after linac-based stereotactic radiosurgery and radiotherapy with a micro-multileaf collimator for brain metastasis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9497847/
https://www.ncbi.nlm.nih.gov/pubmed/36135046
http://dx.doi.org/10.3390/curroncol29090477
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