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Different N-Glycosylation Sites Reduce the Activity of Recombinant DSPAα2

Bat plasminogen activators α2 (DSPAα2) has extremely high medicinal value as a powerful natural thrombolytic protein. However, wild-type DSPAα2 has two N-glycosylation sites (N185 and N398) and its non-human classes of high-mannose-type N-glycans may cause immune responses in vivo. By mutating the N...

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Detalles Bibliográficos
Autores principales:	Peng, Huakang, Wang, Mengqi, Wang, Nan, Yang, Caifeng, Guo, Wenfang, Li, Gangqiang, Huang, Sumei, Wei, Di, Liu, Dehu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9497888/ https://www.ncbi.nlm.nih.gov/pubmed/36135182 http://dx.doi.org/10.3390/cimb44090270

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