Cargando…
(–)-Xanthatin as a Killer of Human Breast Cancer MCF-7 Mammosphere Cells: A Comparative Study with Salinomycin
Experimental evidence accumulated by our research group and others strongly suggests that (–)-xanthatin, a xanthanolide sesquiterpene lactone, exhibits anti-proliferative effects on human breast cancer cells (in vitro) as well as anti-tumor effects in experimental animals (in vivo). In cancer biolog...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9497939/ https://www.ncbi.nlm.nih.gov/pubmed/36135176 http://dx.doi.org/10.3390/cimb44090264 |
_version_ | 1784794632372092928 |
---|---|
author | Takeda, Shuso Hirao-Suzuki, Masayo Shindo, Mitsuru Aramaki, Hironori |
author_facet | Takeda, Shuso Hirao-Suzuki, Masayo Shindo, Mitsuru Aramaki, Hironori |
author_sort | Takeda, Shuso |
collection | PubMed |
description | Experimental evidence accumulated by our research group and others strongly suggests that (–)-xanthatin, a xanthanolide sesquiterpene lactone, exhibits anti-proliferative effects on human breast cancer cells (in vitro) as well as anti-tumor effects in experimental animals (in vivo). In cancer biology, it is now critically important for anti-cancer agents to selectively target cancer stem cells (CSCs) in order to overcome cancer therapeutic resistance and recurrence. However, it has not yet been established whether (–)-xanthatin abrogates the formation of breast CSCs. In the present study, we utilized chemically synthesized pure (–)-xanthatin and a culture system to obtain mammospheres from human breast cancer MCF-7 cells, which are a CSC-enriched population. We herein demonstrated for the first time that (–)-xanthatin exhibited the ability to kill mammospheres, similar to salinomycin, an established selective killer of CSCs. A possible anti-proliferative mechanism toward mammospheres by (–)-xanthatin is discussed. |
format | Online Article Text |
id | pubmed-9497939 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94979392022-09-23 (–)-Xanthatin as a Killer of Human Breast Cancer MCF-7 Mammosphere Cells: A Comparative Study with Salinomycin Takeda, Shuso Hirao-Suzuki, Masayo Shindo, Mitsuru Aramaki, Hironori Curr Issues Mol Biol Communication Experimental evidence accumulated by our research group and others strongly suggests that (–)-xanthatin, a xanthanolide sesquiterpene lactone, exhibits anti-proliferative effects on human breast cancer cells (in vitro) as well as anti-tumor effects in experimental animals (in vivo). In cancer biology, it is now critically important for anti-cancer agents to selectively target cancer stem cells (CSCs) in order to overcome cancer therapeutic resistance and recurrence. However, it has not yet been established whether (–)-xanthatin abrogates the formation of breast CSCs. In the present study, we utilized chemically synthesized pure (–)-xanthatin and a culture system to obtain mammospheres from human breast cancer MCF-7 cells, which are a CSC-enriched population. We herein demonstrated for the first time that (–)-xanthatin exhibited the ability to kill mammospheres, similar to salinomycin, an established selective killer of CSCs. A possible anti-proliferative mechanism toward mammospheres by (–)-xanthatin is discussed. MDPI 2022-08-25 /pmc/articles/PMC9497939/ /pubmed/36135176 http://dx.doi.org/10.3390/cimb44090264 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Communication Takeda, Shuso Hirao-Suzuki, Masayo Shindo, Mitsuru Aramaki, Hironori (–)-Xanthatin as a Killer of Human Breast Cancer MCF-7 Mammosphere Cells: A Comparative Study with Salinomycin |
title | (–)-Xanthatin as a Killer of Human Breast Cancer MCF-7 Mammosphere Cells: A Comparative Study with Salinomycin |
title_full | (–)-Xanthatin as a Killer of Human Breast Cancer MCF-7 Mammosphere Cells: A Comparative Study with Salinomycin |
title_fullStr | (–)-Xanthatin as a Killer of Human Breast Cancer MCF-7 Mammosphere Cells: A Comparative Study with Salinomycin |
title_full_unstemmed | (–)-Xanthatin as a Killer of Human Breast Cancer MCF-7 Mammosphere Cells: A Comparative Study with Salinomycin |
title_short | (–)-Xanthatin as a Killer of Human Breast Cancer MCF-7 Mammosphere Cells: A Comparative Study with Salinomycin |
title_sort | (–)-xanthatin as a killer of human breast cancer mcf-7 mammosphere cells: a comparative study with salinomycin |
topic | Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9497939/ https://www.ncbi.nlm.nih.gov/pubmed/36135176 http://dx.doi.org/10.3390/cimb44090264 |
work_keys_str_mv | AT takedashuso xanthatinasakillerofhumanbreastcancermcf7mammospherecellsacomparativestudywithsalinomycin AT hiraosuzukimasayo xanthatinasakillerofhumanbreastcancermcf7mammospherecellsacomparativestudywithsalinomycin AT shindomitsuru xanthatinasakillerofhumanbreastcancermcf7mammospherecellsacomparativestudywithsalinomycin AT aramakihironori xanthatinasakillerofhumanbreastcancermcf7mammospherecellsacomparativestudywithsalinomycin |