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The Impact of Exercise on Cardiotoxicity in Pediatric and Adolescent Cancer Survivors: A Scoping Review
Childhood and adolescent cancer survivors are disproportionately more likely to develop cardiovascular diseases from the late effects of cardiotoxic therapies (e.g., anthracycline-based chemotherapy and chest-directed radiotherapy). Currently, dexrazoxane is the only approved drug for preventing can...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9497997/ https://www.ncbi.nlm.nih.gov/pubmed/36135069 http://dx.doi.org/10.3390/curroncol29090500 |
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author | Kendall, Stephanie J. Langley, Jodi E. Aghdam, Mohsen Crooks, Bruce N. Giacomantonio, Nicholas Heinze-Milne, Stefan Johnston, Will J. Keats, Melanie R. Mulvagh, Sharon L. Grandy, Scott A. |
author_facet | Kendall, Stephanie J. Langley, Jodi E. Aghdam, Mohsen Crooks, Bruce N. Giacomantonio, Nicholas Heinze-Milne, Stefan Johnston, Will J. Keats, Melanie R. Mulvagh, Sharon L. Grandy, Scott A. |
author_sort | Kendall, Stephanie J. |
collection | PubMed |
description | Childhood and adolescent cancer survivors are disproportionately more likely to develop cardiovascular diseases from the late effects of cardiotoxic therapies (e.g., anthracycline-based chemotherapy and chest-directed radiotherapy). Currently, dexrazoxane is the only approved drug for preventing cancer treatment-related cardiac damage. While animal models highlight the beneficial effects of exercise cancer treatment-related cardiac dysfunction, few clinical studies have been conducted. Thus, the objective of this scoping review was to explore the designs and impact of exercise-based interventions for managing cancer treatment-related cardiac dysfunction in childhood and adolescent cancer survivors. Reviewers used Joanna Briggs Institute’s methodology to identify relevant literature. Then, 4616 studies were screened, and three reviewers extracted relevant data from six reports. Reviewers found that exercise interventions to prevent cancer treatment-related cardiac dysfunction in childhood and adolescent cancer survivors vary regarding frequency, intensity, time, and type of exercise intervention. Further, the review suggests that exercise promotes positive effects on managing cancer treatment-related cardiac dysfunction across numerous indices of heart health. However, the few clinical studies employing exercise interventions for childhood and adolescent cancer survivors highlight the necessity for more research in this area. |
format | Online Article Text |
id | pubmed-9497997 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94979972022-09-23 The Impact of Exercise on Cardiotoxicity in Pediatric and Adolescent Cancer Survivors: A Scoping Review Kendall, Stephanie J. Langley, Jodi E. Aghdam, Mohsen Crooks, Bruce N. Giacomantonio, Nicholas Heinze-Milne, Stefan Johnston, Will J. Keats, Melanie R. Mulvagh, Sharon L. Grandy, Scott A. Curr Oncol Review Childhood and adolescent cancer survivors are disproportionately more likely to develop cardiovascular diseases from the late effects of cardiotoxic therapies (e.g., anthracycline-based chemotherapy and chest-directed radiotherapy). Currently, dexrazoxane is the only approved drug for preventing cancer treatment-related cardiac damage. While animal models highlight the beneficial effects of exercise cancer treatment-related cardiac dysfunction, few clinical studies have been conducted. Thus, the objective of this scoping review was to explore the designs and impact of exercise-based interventions for managing cancer treatment-related cardiac dysfunction in childhood and adolescent cancer survivors. Reviewers used Joanna Briggs Institute’s methodology to identify relevant literature. Then, 4616 studies were screened, and three reviewers extracted relevant data from six reports. Reviewers found that exercise interventions to prevent cancer treatment-related cardiac dysfunction in childhood and adolescent cancer survivors vary regarding frequency, intensity, time, and type of exercise intervention. Further, the review suggests that exercise promotes positive effects on managing cancer treatment-related cardiac dysfunction across numerous indices of heart health. However, the few clinical studies employing exercise interventions for childhood and adolescent cancer survivors highlight the necessity for more research in this area. MDPI 2022-09-03 /pmc/articles/PMC9497997/ /pubmed/36135069 http://dx.doi.org/10.3390/curroncol29090500 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Kendall, Stephanie J. Langley, Jodi E. Aghdam, Mohsen Crooks, Bruce N. Giacomantonio, Nicholas Heinze-Milne, Stefan Johnston, Will J. Keats, Melanie R. Mulvagh, Sharon L. Grandy, Scott A. The Impact of Exercise on Cardiotoxicity in Pediatric and Adolescent Cancer Survivors: A Scoping Review |
title | The Impact of Exercise on Cardiotoxicity in Pediatric and Adolescent Cancer Survivors: A Scoping Review |
title_full | The Impact of Exercise on Cardiotoxicity in Pediatric and Adolescent Cancer Survivors: A Scoping Review |
title_fullStr | The Impact of Exercise on Cardiotoxicity in Pediatric and Adolescent Cancer Survivors: A Scoping Review |
title_full_unstemmed | The Impact of Exercise on Cardiotoxicity in Pediatric and Adolescent Cancer Survivors: A Scoping Review |
title_short | The Impact of Exercise on Cardiotoxicity in Pediatric and Adolescent Cancer Survivors: A Scoping Review |
title_sort | impact of exercise on cardiotoxicity in pediatric and adolescent cancer survivors: a scoping review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9497997/ https://www.ncbi.nlm.nih.gov/pubmed/36135069 http://dx.doi.org/10.3390/curroncol29090500 |
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