Cargando…

The Impact of Exercise on Cardiotoxicity in Pediatric and Adolescent Cancer Survivors: A Scoping Review

Childhood and adolescent cancer survivors are disproportionately more likely to develop cardiovascular diseases from the late effects of cardiotoxic therapies (e.g., anthracycline-based chemotherapy and chest-directed radiotherapy). Currently, dexrazoxane is the only approved drug for preventing can...

Descripción completa

Detalles Bibliográficos
Autores principales: Kendall, Stephanie J., Langley, Jodi E., Aghdam, Mohsen, Crooks, Bruce N., Giacomantonio, Nicholas, Heinze-Milne, Stefan, Johnston, Will J., Keats, Melanie R., Mulvagh, Sharon L., Grandy, Scott A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9497997/
https://www.ncbi.nlm.nih.gov/pubmed/36135069
http://dx.doi.org/10.3390/curroncol29090500
_version_ 1784794646518431744
author Kendall, Stephanie J.
Langley, Jodi E.
Aghdam, Mohsen
Crooks, Bruce N.
Giacomantonio, Nicholas
Heinze-Milne, Stefan
Johnston, Will J.
Keats, Melanie R.
Mulvagh, Sharon L.
Grandy, Scott A.
author_facet Kendall, Stephanie J.
Langley, Jodi E.
Aghdam, Mohsen
Crooks, Bruce N.
Giacomantonio, Nicholas
Heinze-Milne, Stefan
Johnston, Will J.
Keats, Melanie R.
Mulvagh, Sharon L.
Grandy, Scott A.
author_sort Kendall, Stephanie J.
collection PubMed
description Childhood and adolescent cancer survivors are disproportionately more likely to develop cardiovascular diseases from the late effects of cardiotoxic therapies (e.g., anthracycline-based chemotherapy and chest-directed radiotherapy). Currently, dexrazoxane is the only approved drug for preventing cancer treatment-related cardiac damage. While animal models highlight the beneficial effects of exercise cancer treatment-related cardiac dysfunction, few clinical studies have been conducted. Thus, the objective of this scoping review was to explore the designs and impact of exercise-based interventions for managing cancer treatment-related cardiac dysfunction in childhood and adolescent cancer survivors. Reviewers used Joanna Briggs Institute’s methodology to identify relevant literature. Then, 4616 studies were screened, and three reviewers extracted relevant data from six reports. Reviewers found that exercise interventions to prevent cancer treatment-related cardiac dysfunction in childhood and adolescent cancer survivors vary regarding frequency, intensity, time, and type of exercise intervention. Further, the review suggests that exercise promotes positive effects on managing cancer treatment-related cardiac dysfunction across numerous indices of heart health. However, the few clinical studies employing exercise interventions for childhood and adolescent cancer survivors highlight the necessity for more research in this area.
format Online
Article
Text
id pubmed-9497997
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-94979972022-09-23 The Impact of Exercise on Cardiotoxicity in Pediatric and Adolescent Cancer Survivors: A Scoping Review Kendall, Stephanie J. Langley, Jodi E. Aghdam, Mohsen Crooks, Bruce N. Giacomantonio, Nicholas Heinze-Milne, Stefan Johnston, Will J. Keats, Melanie R. Mulvagh, Sharon L. Grandy, Scott A. Curr Oncol Review Childhood and adolescent cancer survivors are disproportionately more likely to develop cardiovascular diseases from the late effects of cardiotoxic therapies (e.g., anthracycline-based chemotherapy and chest-directed radiotherapy). Currently, dexrazoxane is the only approved drug for preventing cancer treatment-related cardiac damage. While animal models highlight the beneficial effects of exercise cancer treatment-related cardiac dysfunction, few clinical studies have been conducted. Thus, the objective of this scoping review was to explore the designs and impact of exercise-based interventions for managing cancer treatment-related cardiac dysfunction in childhood and adolescent cancer survivors. Reviewers used Joanna Briggs Institute’s methodology to identify relevant literature. Then, 4616 studies were screened, and three reviewers extracted relevant data from six reports. Reviewers found that exercise interventions to prevent cancer treatment-related cardiac dysfunction in childhood and adolescent cancer survivors vary regarding frequency, intensity, time, and type of exercise intervention. Further, the review suggests that exercise promotes positive effects on managing cancer treatment-related cardiac dysfunction across numerous indices of heart health. However, the few clinical studies employing exercise interventions for childhood and adolescent cancer survivors highlight the necessity for more research in this area. MDPI 2022-09-03 /pmc/articles/PMC9497997/ /pubmed/36135069 http://dx.doi.org/10.3390/curroncol29090500 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kendall, Stephanie J.
Langley, Jodi E.
Aghdam, Mohsen
Crooks, Bruce N.
Giacomantonio, Nicholas
Heinze-Milne, Stefan
Johnston, Will J.
Keats, Melanie R.
Mulvagh, Sharon L.
Grandy, Scott A.
The Impact of Exercise on Cardiotoxicity in Pediatric and Adolescent Cancer Survivors: A Scoping Review
title The Impact of Exercise on Cardiotoxicity in Pediatric and Adolescent Cancer Survivors: A Scoping Review
title_full The Impact of Exercise on Cardiotoxicity in Pediatric and Adolescent Cancer Survivors: A Scoping Review
title_fullStr The Impact of Exercise on Cardiotoxicity in Pediatric and Adolescent Cancer Survivors: A Scoping Review
title_full_unstemmed The Impact of Exercise on Cardiotoxicity in Pediatric and Adolescent Cancer Survivors: A Scoping Review
title_short The Impact of Exercise on Cardiotoxicity in Pediatric and Adolescent Cancer Survivors: A Scoping Review
title_sort impact of exercise on cardiotoxicity in pediatric and adolescent cancer survivors: a scoping review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9497997/
https://www.ncbi.nlm.nih.gov/pubmed/36135069
http://dx.doi.org/10.3390/curroncol29090500
work_keys_str_mv AT kendallstephaniej theimpactofexerciseoncardiotoxicityinpediatricandadolescentcancersurvivorsascopingreview
AT langleyjodie theimpactofexerciseoncardiotoxicityinpediatricandadolescentcancersurvivorsascopingreview
AT aghdammohsen theimpactofexerciseoncardiotoxicityinpediatricandadolescentcancersurvivorsascopingreview
AT crooksbrucen theimpactofexerciseoncardiotoxicityinpediatricandadolescentcancersurvivorsascopingreview
AT giacomantonionicholas theimpactofexerciseoncardiotoxicityinpediatricandadolescentcancersurvivorsascopingreview
AT heinzemilnestefan theimpactofexerciseoncardiotoxicityinpediatricandadolescentcancersurvivorsascopingreview
AT johnstonwillj theimpactofexerciseoncardiotoxicityinpediatricandadolescentcancersurvivorsascopingreview
AT keatsmelanier theimpactofexerciseoncardiotoxicityinpediatricandadolescentcancersurvivorsascopingreview
AT mulvaghsharonl theimpactofexerciseoncardiotoxicityinpediatricandadolescentcancersurvivorsascopingreview
AT grandyscotta theimpactofexerciseoncardiotoxicityinpediatricandadolescentcancersurvivorsascopingreview
AT kendallstephaniej impactofexerciseoncardiotoxicityinpediatricandadolescentcancersurvivorsascopingreview
AT langleyjodie impactofexerciseoncardiotoxicityinpediatricandadolescentcancersurvivorsascopingreview
AT aghdammohsen impactofexerciseoncardiotoxicityinpediatricandadolescentcancersurvivorsascopingreview
AT crooksbrucen impactofexerciseoncardiotoxicityinpediatricandadolescentcancersurvivorsascopingreview
AT giacomantonionicholas impactofexerciseoncardiotoxicityinpediatricandadolescentcancersurvivorsascopingreview
AT heinzemilnestefan impactofexerciseoncardiotoxicityinpediatricandadolescentcancersurvivorsascopingreview
AT johnstonwillj impactofexerciseoncardiotoxicityinpediatricandadolescentcancersurvivorsascopingreview
AT keatsmelanier impactofexerciseoncardiotoxicityinpediatricandadolescentcancersurvivorsascopingreview
AT mulvaghsharonl impactofexerciseoncardiotoxicityinpediatricandadolescentcancersurvivorsascopingreview
AT grandyscotta impactofexerciseoncardiotoxicityinpediatricandadolescentcancersurvivorsascopingreview