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Changes in Apparent Diffusion Coefficient (ADC) in Serial Weekly MRI during Radiotherapy in Patients with Head and Neck Cancer: Results from the PREDICT-HN Study

Background: The PREDICT-HN study aimed to systematically assess the kinetics of imaging MR biomarkers during head and neck radiotherapy. Methods: Patients with intact squamous cell carcinoma of the head and neck were enrolled. Pre-, during, and post-treatment MRI were obtained. Serial GTV and ADC me...

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Autores principales: Ng, Sweet Ping, Cardenas, Carlos E., Bahig, Houda, Elgohari, Baher, Wang, Jihong, Johnson, Jason M., Moreno, Amy C., Shah, Shalin J., Garden, Adam S., Phan, Jack, Gunn, G. Brandon, Frank, Steven J., Ding, Yao, Na, Lumine, Yuan, Ying, Urbauer, Diana, Mohamed, Abdallah S. R., Rosenthal, David I., Morrison, William H., MacManus, Michael P., Fuller, Clifton D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9498049/
https://www.ncbi.nlm.nih.gov/pubmed/36135064
http://dx.doi.org/10.3390/curroncol29090495
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author Ng, Sweet Ping
Cardenas, Carlos E.
Bahig, Houda
Elgohari, Baher
Wang, Jihong
Johnson, Jason M.
Moreno, Amy C.
Shah, Shalin J.
Garden, Adam S.
Phan, Jack
Gunn, G. Brandon
Frank, Steven J.
Ding, Yao
Na, Lumine
Yuan, Ying
Urbauer, Diana
Mohamed, Abdallah S. R.
Rosenthal, David I.
Morrison, William H.
MacManus, Michael P.
Fuller, Clifton D.
author_facet Ng, Sweet Ping
Cardenas, Carlos E.
Bahig, Houda
Elgohari, Baher
Wang, Jihong
Johnson, Jason M.
Moreno, Amy C.
Shah, Shalin J.
Garden, Adam S.
Phan, Jack
Gunn, G. Brandon
Frank, Steven J.
Ding, Yao
Na, Lumine
Yuan, Ying
Urbauer, Diana
Mohamed, Abdallah S. R.
Rosenthal, David I.
Morrison, William H.
MacManus, Michael P.
Fuller, Clifton D.
author_sort Ng, Sweet Ping
collection PubMed
description Background: The PREDICT-HN study aimed to systematically assess the kinetics of imaging MR biomarkers during head and neck radiotherapy. Methods: Patients with intact squamous cell carcinoma of the head and neck were enrolled. Pre-, during, and post-treatment MRI were obtained. Serial GTV and ADC measurements were recorded. The correlation between each feature and the GTV was calculated using Spearman’s correlation coefficient. The linear mixed model was used to evaluate the change in GTV over time. Results: A total of 41 patients completed the study. The majority (76%) had oropharyngeal cancer. A total of 36 patients had intact primary tumours that can be assessed on MRI, and 31 patients had nodal disease with 46 nodes assessed. Median primary GTV (GTVp) size was 14.1cc. The rate of GTVp shrinkage was highest between pre-treatment and week 4. Patients with T3-T4 tumours had a 3.8-fold decrease in GTVp compared to T1-T2 tumours. The ADC values correlated with residual GTVp. The median nodal volume (GTVn) was 12.4cc. No clinical features were found to correlate with GTVn reduction. The overall change in ADC for GTVn from pre-treatment was significant for 35th–95th percentiles in weeks 1–4 (p < 0.001). Conclusion: A discrepancy in the trajectory of ADC between primary and nodal sites suggested that they exhibit different treatment responses and should be analysed separately in future studies.
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spelling pubmed-94980492022-09-23 Changes in Apparent Diffusion Coefficient (ADC) in Serial Weekly MRI during Radiotherapy in Patients with Head and Neck Cancer: Results from the PREDICT-HN Study Ng, Sweet Ping Cardenas, Carlos E. Bahig, Houda Elgohari, Baher Wang, Jihong Johnson, Jason M. Moreno, Amy C. Shah, Shalin J. Garden, Adam S. Phan, Jack Gunn, G. Brandon Frank, Steven J. Ding, Yao Na, Lumine Yuan, Ying Urbauer, Diana Mohamed, Abdallah S. R. Rosenthal, David I. Morrison, William H. MacManus, Michael P. Fuller, Clifton D. Curr Oncol Article Background: The PREDICT-HN study aimed to systematically assess the kinetics of imaging MR biomarkers during head and neck radiotherapy. Methods: Patients with intact squamous cell carcinoma of the head and neck were enrolled. Pre-, during, and post-treatment MRI were obtained. Serial GTV and ADC measurements were recorded. The correlation between each feature and the GTV was calculated using Spearman’s correlation coefficient. The linear mixed model was used to evaluate the change in GTV over time. Results: A total of 41 patients completed the study. The majority (76%) had oropharyngeal cancer. A total of 36 patients had intact primary tumours that can be assessed on MRI, and 31 patients had nodal disease with 46 nodes assessed. Median primary GTV (GTVp) size was 14.1cc. The rate of GTVp shrinkage was highest between pre-treatment and week 4. Patients with T3-T4 tumours had a 3.8-fold decrease in GTVp compared to T1-T2 tumours. The ADC values correlated with residual GTVp. The median nodal volume (GTVn) was 12.4cc. No clinical features were found to correlate with GTVn reduction. The overall change in ADC for GTVn from pre-treatment was significant for 35th–95th percentiles in weeks 1–4 (p < 0.001). Conclusion: A discrepancy in the trajectory of ADC between primary and nodal sites suggested that they exhibit different treatment responses and should be analysed separately in future studies. MDPI 2022-08-31 /pmc/articles/PMC9498049/ /pubmed/36135064 http://dx.doi.org/10.3390/curroncol29090495 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ng, Sweet Ping
Cardenas, Carlos E.
Bahig, Houda
Elgohari, Baher
Wang, Jihong
Johnson, Jason M.
Moreno, Amy C.
Shah, Shalin J.
Garden, Adam S.
Phan, Jack
Gunn, G. Brandon
Frank, Steven J.
Ding, Yao
Na, Lumine
Yuan, Ying
Urbauer, Diana
Mohamed, Abdallah S. R.
Rosenthal, David I.
Morrison, William H.
MacManus, Michael P.
Fuller, Clifton D.
Changes in Apparent Diffusion Coefficient (ADC) in Serial Weekly MRI during Radiotherapy in Patients with Head and Neck Cancer: Results from the PREDICT-HN Study
title Changes in Apparent Diffusion Coefficient (ADC) in Serial Weekly MRI during Radiotherapy in Patients with Head and Neck Cancer: Results from the PREDICT-HN Study
title_full Changes in Apparent Diffusion Coefficient (ADC) in Serial Weekly MRI during Radiotherapy in Patients with Head and Neck Cancer: Results from the PREDICT-HN Study
title_fullStr Changes in Apparent Diffusion Coefficient (ADC) in Serial Weekly MRI during Radiotherapy in Patients with Head and Neck Cancer: Results from the PREDICT-HN Study
title_full_unstemmed Changes in Apparent Diffusion Coefficient (ADC) in Serial Weekly MRI during Radiotherapy in Patients with Head and Neck Cancer: Results from the PREDICT-HN Study
title_short Changes in Apparent Diffusion Coefficient (ADC) in Serial Weekly MRI during Radiotherapy in Patients with Head and Neck Cancer: Results from the PREDICT-HN Study
title_sort changes in apparent diffusion coefficient (adc) in serial weekly mri during radiotherapy in patients with head and neck cancer: results from the predict-hn study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9498049/
https://www.ncbi.nlm.nih.gov/pubmed/36135064
http://dx.doi.org/10.3390/curroncol29090495
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