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Protective Effect of Virgin Coconut Oil on Osteopenia Induced by High Refined Carbohydrate-Containing Diet in Mice

Background: Obesity leads to chronic low-grade inflammation, promoting detrimental effects on bone. The consumption of virgin coconut oil (VCO) is associated with benefits related to meta-inflammation. We evaluated the effect of VCO supplementation on osteopenia promoted by diet-induced obesity in m...

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Autores principales: Zicker, Marina C., Montalvany-Antonucci, Carina C., Lacerda, Débora R., Oliveira, Marina C., Silva, Tarcília A., Macari, Soraia, Madeira, Mila F. M., Ferreira, Adaliene V. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9498055/
https://www.ncbi.nlm.nih.gov/pubmed/36140928
http://dx.doi.org/10.3390/foods11182800
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author Zicker, Marina C.
Montalvany-Antonucci, Carina C.
Lacerda, Débora R.
Oliveira, Marina C.
Silva, Tarcília A.
Macari, Soraia
Madeira, Mila F. M.
Ferreira, Adaliene V. M.
author_facet Zicker, Marina C.
Montalvany-Antonucci, Carina C.
Lacerda, Débora R.
Oliveira, Marina C.
Silva, Tarcília A.
Macari, Soraia
Madeira, Mila F. M.
Ferreira, Adaliene V. M.
author_sort Zicker, Marina C.
collection PubMed
description Background: Obesity leads to chronic low-grade inflammation, promoting detrimental effects on bone. The consumption of virgin coconut oil (VCO) is associated with benefits related to meta-inflammation. We evaluated the effect of VCO supplementation on osteopenia promoted by diet-induced obesity in mice. Methods: Male BALB/c mice were fed a control (C) or highly refined carbohydrate-containing (HC) diet for eight weeks. After that, the HC diet group was supplemented with three doses of VCO for four weeks. Results: The HC diet increased the adiposity and leptin levels associated with augmented systemic inflammatory cells improved with VCO supplementation. The HC diet reduced the trabecular bone in the tibia, lumbar vertebrae, distal and proximal femur, as well as the bone mineral density of the femur and alveolar bone. The VCO supplementation reverted bone osteopenia by increasing the trabecular bone in different sites and improving femur and alveolar bone microarchitecture. Although the reduced number of osteoblasts in the alveolar bone of the HC diet group was not significantly enhanced by VCO supplementation, the reduced Alp expression in the HC diet group was enhanced in the VCO group. These beneficial effects were associated with lowering the Rankl/Opg ratio. Conclusion: VCO supplementation might be an effective strategy to attenuate bone osteopenic effects induced by obesity.
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spelling pubmed-94980552022-09-23 Protective Effect of Virgin Coconut Oil on Osteopenia Induced by High Refined Carbohydrate-Containing Diet in Mice Zicker, Marina C. Montalvany-Antonucci, Carina C. Lacerda, Débora R. Oliveira, Marina C. Silva, Tarcília A. Macari, Soraia Madeira, Mila F. M. Ferreira, Adaliene V. M. Foods Article Background: Obesity leads to chronic low-grade inflammation, promoting detrimental effects on bone. The consumption of virgin coconut oil (VCO) is associated with benefits related to meta-inflammation. We evaluated the effect of VCO supplementation on osteopenia promoted by diet-induced obesity in mice. Methods: Male BALB/c mice were fed a control (C) or highly refined carbohydrate-containing (HC) diet for eight weeks. After that, the HC diet group was supplemented with three doses of VCO for four weeks. Results: The HC diet increased the adiposity and leptin levels associated with augmented systemic inflammatory cells improved with VCO supplementation. The HC diet reduced the trabecular bone in the tibia, lumbar vertebrae, distal and proximal femur, as well as the bone mineral density of the femur and alveolar bone. The VCO supplementation reverted bone osteopenia by increasing the trabecular bone in different sites and improving femur and alveolar bone microarchitecture. Although the reduced number of osteoblasts in the alveolar bone of the HC diet group was not significantly enhanced by VCO supplementation, the reduced Alp expression in the HC diet group was enhanced in the VCO group. These beneficial effects were associated with lowering the Rankl/Opg ratio. Conclusion: VCO supplementation might be an effective strategy to attenuate bone osteopenic effects induced by obesity. MDPI 2022-09-11 /pmc/articles/PMC9498055/ /pubmed/36140928 http://dx.doi.org/10.3390/foods11182800 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zicker, Marina C.
Montalvany-Antonucci, Carina C.
Lacerda, Débora R.
Oliveira, Marina C.
Silva, Tarcília A.
Macari, Soraia
Madeira, Mila F. M.
Ferreira, Adaliene V. M.
Protective Effect of Virgin Coconut Oil on Osteopenia Induced by High Refined Carbohydrate-Containing Diet in Mice
title Protective Effect of Virgin Coconut Oil on Osteopenia Induced by High Refined Carbohydrate-Containing Diet in Mice
title_full Protective Effect of Virgin Coconut Oil on Osteopenia Induced by High Refined Carbohydrate-Containing Diet in Mice
title_fullStr Protective Effect of Virgin Coconut Oil on Osteopenia Induced by High Refined Carbohydrate-Containing Diet in Mice
title_full_unstemmed Protective Effect of Virgin Coconut Oil on Osteopenia Induced by High Refined Carbohydrate-Containing Diet in Mice
title_short Protective Effect of Virgin Coconut Oil on Osteopenia Induced by High Refined Carbohydrate-Containing Diet in Mice
title_sort protective effect of virgin coconut oil on osteopenia induced by high refined carbohydrate-containing diet in mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9498055/
https://www.ncbi.nlm.nih.gov/pubmed/36140928
http://dx.doi.org/10.3390/foods11182800
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