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Reappraisal of VEGF in the Pathogenesis of Kawasaki Disease
Vascular endothelial growth factor (VEGF) is an important factor in mediating the inflammation of Kawasaki disease (KD). The literature regarding the relationship between VEGF and KD is sparse. The purpose of this study was to investigate the correlation of VEGF and KD. In a prospective study of 42...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9498069/ https://www.ncbi.nlm.nih.gov/pubmed/36138652 http://dx.doi.org/10.3390/children9091343 |
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author | Chen, Chun-Yu Huang, Shih-Hui Chien, Kuang-Jen Lai, Tsung-Jen Chang, Wei-Hsiang Hsieh, Kai-Sheng Weng, Ken-Pen |
author_facet | Chen, Chun-Yu Huang, Shih-Hui Chien, Kuang-Jen Lai, Tsung-Jen Chang, Wei-Hsiang Hsieh, Kai-Sheng Weng, Ken-Pen |
author_sort | Chen, Chun-Yu |
collection | PubMed |
description | Vascular endothelial growth factor (VEGF) is an important factor in mediating the inflammation of Kawasaki disease (KD). The literature regarding the relationship between VEGF and KD is sparse. The purpose of this study was to investigate the correlation of VEGF and KD. In a prospective study of 42 Taiwanese KD patients (18.9 ± 12.2 months, M/F 22/20) treated with intravenous immunoglobulin (IVIG), a series of VEGF levels was measured from the acute to convalescent phases. KD patients were classified into two subgroups with (n =20) and without (n = 22) acute coronary artery lesions (CALs). Control samples were obtained from 30 febrile controls (19.1 ± 13.7 months, M/F 13/17). In KD patients, VEGF levels in the pre-IVIG acute phase were significantly higher than those in the subacute and convalescent phases (both p < 0.001). In KD patients with CALs, VEGF levels significantly increased immediately in the post-IVIG phase (p = 0.039), and then significantly decreased in the subacute phase (p = 0.002). KD patients with acute CALs had higher median VEGF levels than those without acute CALs from acute to convalescent phases. In the subacute phase, KD patients with acute CALs had significantly higher VEGF levels (p = 0.022) than those without acute CALs. Our data show that VEGF did not decrease after IVIG treatment, and increased significantly after IVIG treatment in KD patients with acute CALs in acute phase. VEGF might be related to the complications of CALs in KD patients. |
format | Online Article Text |
id | pubmed-9498069 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94980692022-09-23 Reappraisal of VEGF in the Pathogenesis of Kawasaki Disease Chen, Chun-Yu Huang, Shih-Hui Chien, Kuang-Jen Lai, Tsung-Jen Chang, Wei-Hsiang Hsieh, Kai-Sheng Weng, Ken-Pen Children (Basel) Article Vascular endothelial growth factor (VEGF) is an important factor in mediating the inflammation of Kawasaki disease (KD). The literature regarding the relationship between VEGF and KD is sparse. The purpose of this study was to investigate the correlation of VEGF and KD. In a prospective study of 42 Taiwanese KD patients (18.9 ± 12.2 months, M/F 22/20) treated with intravenous immunoglobulin (IVIG), a series of VEGF levels was measured from the acute to convalescent phases. KD patients were classified into two subgroups with (n =20) and without (n = 22) acute coronary artery lesions (CALs). Control samples were obtained from 30 febrile controls (19.1 ± 13.7 months, M/F 13/17). In KD patients, VEGF levels in the pre-IVIG acute phase were significantly higher than those in the subacute and convalescent phases (both p < 0.001). In KD patients with CALs, VEGF levels significantly increased immediately in the post-IVIG phase (p = 0.039), and then significantly decreased in the subacute phase (p = 0.002). KD patients with acute CALs had higher median VEGF levels than those without acute CALs from acute to convalescent phases. In the subacute phase, KD patients with acute CALs had significantly higher VEGF levels (p = 0.022) than those without acute CALs. Our data show that VEGF did not decrease after IVIG treatment, and increased significantly after IVIG treatment in KD patients with acute CALs in acute phase. VEGF might be related to the complications of CALs in KD patients. MDPI 2022-09-01 /pmc/articles/PMC9498069/ /pubmed/36138652 http://dx.doi.org/10.3390/children9091343 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Chen, Chun-Yu Huang, Shih-Hui Chien, Kuang-Jen Lai, Tsung-Jen Chang, Wei-Hsiang Hsieh, Kai-Sheng Weng, Ken-Pen Reappraisal of VEGF in the Pathogenesis of Kawasaki Disease |
title | Reappraisal of VEGF in the Pathogenesis of Kawasaki Disease |
title_full | Reappraisal of VEGF in the Pathogenesis of Kawasaki Disease |
title_fullStr | Reappraisal of VEGF in the Pathogenesis of Kawasaki Disease |
title_full_unstemmed | Reappraisal of VEGF in the Pathogenesis of Kawasaki Disease |
title_short | Reappraisal of VEGF in the Pathogenesis of Kawasaki Disease |
title_sort | reappraisal of vegf in the pathogenesis of kawasaki disease |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9498069/ https://www.ncbi.nlm.nih.gov/pubmed/36138652 http://dx.doi.org/10.3390/children9091343 |
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