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Risk Predictors of Advanced Fibrosis in Non-Alcoholic Fatty Liver Disease
The assessment of fibrosis in chronic liver diseases using non-invasive methods is an important topic in hepatology. The aim of this study is to identify patients with non-alcoholic fatty liver disease (NAFLD) and advanced liver fibrosis by establishing correlations between biological/ultrasound mar...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9498120/ https://www.ncbi.nlm.nih.gov/pubmed/36140537 http://dx.doi.org/10.3390/diagnostics12092136 |
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author | Olteanu, Vasile-Andrei Balan, Gheorghe G. Timofte, Oana Dascalu, Cristina Gena Gologan, Elena Gilca-Blanariu, Georgiana-Emanuela Diac, Madalina-Maria Sandu, Ion Stefanescu, Gabriela |
author_facet | Olteanu, Vasile-Andrei Balan, Gheorghe G. Timofte, Oana Dascalu, Cristina Gena Gologan, Elena Gilca-Blanariu, Georgiana-Emanuela Diac, Madalina-Maria Sandu, Ion Stefanescu, Gabriela |
author_sort | Olteanu, Vasile-Andrei |
collection | PubMed |
description | The assessment of fibrosis in chronic liver diseases using non-invasive methods is an important topic in hepatology. The aim of this study is to identify patients with non-alcoholic fatty liver disease (NAFLD) and advanced liver fibrosis by establishing correlations between biological/ultrasound markers and non-invasively measured liver stiffness. This study enrolled 116 patients with non-alcoholic fatty liver disease, which were evaluated clinically, biologically, and by ultrasound. Liver fibrosis was quantified by measuring liver stiffness by shear wave elastography (SWE). Multiple correlation analysis of predictors of liver fibrosis identified a number of clinical, biological, and ultrasound parameters (BMI, blood glucose, albumin, platelet count, portal vein diameter, bipolar spleen diameter) that are associated with advanced liver fibrosis in patients with non-alcoholic fatty liver disease. The correlations between the degree of liver fibrosis and the risk values of some serological and ultrasound markers obtained in our study could be useful in clinical practice for the identification of advanced fibrosis in patients with NAFLD. |
format | Online Article Text |
id | pubmed-9498120 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94981202022-09-23 Risk Predictors of Advanced Fibrosis in Non-Alcoholic Fatty Liver Disease Olteanu, Vasile-Andrei Balan, Gheorghe G. Timofte, Oana Dascalu, Cristina Gena Gologan, Elena Gilca-Blanariu, Georgiana-Emanuela Diac, Madalina-Maria Sandu, Ion Stefanescu, Gabriela Diagnostics (Basel) Article The assessment of fibrosis in chronic liver diseases using non-invasive methods is an important topic in hepatology. The aim of this study is to identify patients with non-alcoholic fatty liver disease (NAFLD) and advanced liver fibrosis by establishing correlations between biological/ultrasound markers and non-invasively measured liver stiffness. This study enrolled 116 patients with non-alcoholic fatty liver disease, which were evaluated clinically, biologically, and by ultrasound. Liver fibrosis was quantified by measuring liver stiffness by shear wave elastography (SWE). Multiple correlation analysis of predictors of liver fibrosis identified a number of clinical, biological, and ultrasound parameters (BMI, blood glucose, albumin, platelet count, portal vein diameter, bipolar spleen diameter) that are associated with advanced liver fibrosis in patients with non-alcoholic fatty liver disease. The correlations between the degree of liver fibrosis and the risk values of some serological and ultrasound markers obtained in our study could be useful in clinical practice for the identification of advanced fibrosis in patients with NAFLD. MDPI 2022-09-02 /pmc/articles/PMC9498120/ /pubmed/36140537 http://dx.doi.org/10.3390/diagnostics12092136 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Olteanu, Vasile-Andrei Balan, Gheorghe G. Timofte, Oana Dascalu, Cristina Gena Gologan, Elena Gilca-Blanariu, Georgiana-Emanuela Diac, Madalina-Maria Sandu, Ion Stefanescu, Gabriela Risk Predictors of Advanced Fibrosis in Non-Alcoholic Fatty Liver Disease |
title | Risk Predictors of Advanced Fibrosis in Non-Alcoholic Fatty Liver Disease |
title_full | Risk Predictors of Advanced Fibrosis in Non-Alcoholic Fatty Liver Disease |
title_fullStr | Risk Predictors of Advanced Fibrosis in Non-Alcoholic Fatty Liver Disease |
title_full_unstemmed | Risk Predictors of Advanced Fibrosis in Non-Alcoholic Fatty Liver Disease |
title_short | Risk Predictors of Advanced Fibrosis in Non-Alcoholic Fatty Liver Disease |
title_sort | risk predictors of advanced fibrosis in non-alcoholic fatty liver disease |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9498120/ https://www.ncbi.nlm.nih.gov/pubmed/36140537 http://dx.doi.org/10.3390/diagnostics12092136 |
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