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Do the Causes of Spontaneous Preterm Delivery Affect Placental Inflammatory Pathology and Neonatal Outcomes?

Objective: To investigate the severity of histologic chorioamnionitis /funisitis according to the indication for preterm delivery and their corresponding neonatal outcomes. Method: This study included 411 singleton women who delivered between 21(+0) and 31(+6) week of gestation due to preterm labor...

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Autores principales: Jang, Il-Yeo, Jung, Hye-Ji, Sung, Ji-Hee, Choi, Suk-Joo, Oh, Soo-Young, Kim, Jung-Sun, Roh, Cheong-Rae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9498177/
https://www.ncbi.nlm.nih.gov/pubmed/36140528
http://dx.doi.org/10.3390/diagnostics12092126
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author Jang, Il-Yeo
Jung, Hye-Ji
Sung, Ji-Hee
Choi, Suk-Joo
Oh, Soo-Young
Kim, Jung-Sun
Roh, Cheong-Rae
author_facet Jang, Il-Yeo
Jung, Hye-Ji
Sung, Ji-Hee
Choi, Suk-Joo
Oh, Soo-Young
Kim, Jung-Sun
Roh, Cheong-Rae
author_sort Jang, Il-Yeo
collection PubMed
description Objective: To investigate the severity of histologic chorioamnionitis /funisitis according to the indication for preterm delivery and their corresponding neonatal outcomes. Method: This study included 411 singleton women who delivered between 21(+0) and 31(+6) week of gestation due to preterm labor (PTL, n = 165), preterm premature rupture of membranes (PPROM, n = 202), or incompetent internal os of the cervix (IIOC, n = 44). The primary outcome measure was the rate of severe histological chorioamnionitis/funisitis. Secondary outcome measure was neonatal outcomes including neonatal and infant death, and neonatal composite morbidity. Results: The PPROM group demonstrated a higher rate of severe histological chorioamnionitis/funisitis compared to the PTL group (severe histological chorioamnionitis; PPROM, 66.3% vs. PTL, 49.1%, p = 0.001, severe funisitis; PPROM, 44.1% vs. PTL, 23.6%, p < 0.001) and this remained significant after multivariable analysis (severe histologic chorioamnionitis, OR 2.367, 95% CI 1.517–3.693; severe funisitis, OR 2.668, 95% CI 1.684–4.226). For neonatal outcomes only, a higher rate of patent ductus arteriosus was observed in the IIOC group compared to the PTL and PPROM groups (IIOC, 77.3% vs. PTL, 54.0% vs. PPROM, 54.0%, p = 0.043) and this remained significant after multivariable analysis. Conclusion: Indication of spontaneous preterm delivery might affect the placental inflammatory pathology and neonatal morbidity.
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spelling pubmed-94981772022-09-23 Do the Causes of Spontaneous Preterm Delivery Affect Placental Inflammatory Pathology and Neonatal Outcomes? Jang, Il-Yeo Jung, Hye-Ji Sung, Ji-Hee Choi, Suk-Joo Oh, Soo-Young Kim, Jung-Sun Roh, Cheong-Rae Diagnostics (Basel) Article Objective: To investigate the severity of histologic chorioamnionitis /funisitis according to the indication for preterm delivery and their corresponding neonatal outcomes. Method: This study included 411 singleton women who delivered between 21(+0) and 31(+6) week of gestation due to preterm labor (PTL, n = 165), preterm premature rupture of membranes (PPROM, n = 202), or incompetent internal os of the cervix (IIOC, n = 44). The primary outcome measure was the rate of severe histological chorioamnionitis/funisitis. Secondary outcome measure was neonatal outcomes including neonatal and infant death, and neonatal composite morbidity. Results: The PPROM group demonstrated a higher rate of severe histological chorioamnionitis/funisitis compared to the PTL group (severe histological chorioamnionitis; PPROM, 66.3% vs. PTL, 49.1%, p = 0.001, severe funisitis; PPROM, 44.1% vs. PTL, 23.6%, p < 0.001) and this remained significant after multivariable analysis (severe histologic chorioamnionitis, OR 2.367, 95% CI 1.517–3.693; severe funisitis, OR 2.668, 95% CI 1.684–4.226). For neonatal outcomes only, a higher rate of patent ductus arteriosus was observed in the IIOC group compared to the PTL and PPROM groups (IIOC, 77.3% vs. PTL, 54.0% vs. PPROM, 54.0%, p = 0.043) and this remained significant after multivariable analysis. Conclusion: Indication of spontaneous preterm delivery might affect the placental inflammatory pathology and neonatal morbidity. MDPI 2022-09-01 /pmc/articles/PMC9498177/ /pubmed/36140528 http://dx.doi.org/10.3390/diagnostics12092126 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Jang, Il-Yeo
Jung, Hye-Ji
Sung, Ji-Hee
Choi, Suk-Joo
Oh, Soo-Young
Kim, Jung-Sun
Roh, Cheong-Rae
Do the Causes of Spontaneous Preterm Delivery Affect Placental Inflammatory Pathology and Neonatal Outcomes?
title Do the Causes of Spontaneous Preterm Delivery Affect Placental Inflammatory Pathology and Neonatal Outcomes?
title_full Do the Causes of Spontaneous Preterm Delivery Affect Placental Inflammatory Pathology and Neonatal Outcomes?
title_fullStr Do the Causes of Spontaneous Preterm Delivery Affect Placental Inflammatory Pathology and Neonatal Outcomes?
title_full_unstemmed Do the Causes of Spontaneous Preterm Delivery Affect Placental Inflammatory Pathology and Neonatal Outcomes?
title_short Do the Causes of Spontaneous Preterm Delivery Affect Placental Inflammatory Pathology and Neonatal Outcomes?
title_sort do the causes of spontaneous preterm delivery affect placental inflammatory pathology and neonatal outcomes?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9498177/
https://www.ncbi.nlm.nih.gov/pubmed/36140528
http://dx.doi.org/10.3390/diagnostics12092126
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