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Giant Paratesticular Liposarcoma: Molecular Characterization and Management Principles with a Review of the Literature
Paratesticular liposarcomas are extremely rare malignant tumors originating from fat tissues, with an often-challenging diagnosis. We present here the case of a 76-year-old man with a giant paratesticular liposarcoma, initially misdiagnosed as a scrotal hernia. After two years, the progressively enl...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9498211/ https://www.ncbi.nlm.nih.gov/pubmed/36140560 http://dx.doi.org/10.3390/diagnostics12092160 |
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author | Pavone, Giuliana Romano, Chiara Martorana, Federica Motta, Lucia Salvatorelli, Lucia Zanghì, Antonio Maria Magro, Gaetano Vigneri, Paolo |
author_facet | Pavone, Giuliana Romano, Chiara Martorana, Federica Motta, Lucia Salvatorelli, Lucia Zanghì, Antonio Maria Magro, Gaetano Vigneri, Paolo |
author_sort | Pavone, Giuliana |
collection | PubMed |
description | Paratesticular liposarcomas are extremely rare malignant tumors originating from fat tissues, with an often-challenging diagnosis. We present here the case of a 76-year-old man with a giant paratesticular liposarcoma, initially misdiagnosed as a scrotal hernia. After two years, the progressively enlarging mass underwent surgical resection, and a diagnosis of well-differentiated liposarcoma (lipoma-like subtype) was made. Post-operative treatments were not indicated, and the patient remains relapse free. Next generation sequencing performed on the neoplastic tissue showed co-amplification of MDM2 and CDK4. These alterations are molecular hallmarks of well-differentiated liposarcomas and corroborate the histological diagnosis. Clinical and molecular features of the presented case are in line with the majority of previously published experiences. In conclusion, the presence of a liposarcoma should be taken into account during the diagnostic workup of scrotal masses, in order to minimize the rate of misdiagnosis and improper management. Molecular analysis may support histological characterization of these rare entities and potentially disclose novel therapeutic targets. |
format | Online Article Text |
id | pubmed-9498211 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94982112022-09-23 Giant Paratesticular Liposarcoma: Molecular Characterization and Management Principles with a Review of the Literature Pavone, Giuliana Romano, Chiara Martorana, Federica Motta, Lucia Salvatorelli, Lucia Zanghì, Antonio Maria Magro, Gaetano Vigneri, Paolo Diagnostics (Basel) Interesting Images Paratesticular liposarcomas are extremely rare malignant tumors originating from fat tissues, with an often-challenging diagnosis. We present here the case of a 76-year-old man with a giant paratesticular liposarcoma, initially misdiagnosed as a scrotal hernia. After two years, the progressively enlarging mass underwent surgical resection, and a diagnosis of well-differentiated liposarcoma (lipoma-like subtype) was made. Post-operative treatments were not indicated, and the patient remains relapse free. Next generation sequencing performed on the neoplastic tissue showed co-amplification of MDM2 and CDK4. These alterations are molecular hallmarks of well-differentiated liposarcomas and corroborate the histological diagnosis. Clinical and molecular features of the presented case are in line with the majority of previously published experiences. In conclusion, the presence of a liposarcoma should be taken into account during the diagnostic workup of scrotal masses, in order to minimize the rate of misdiagnosis and improper management. Molecular analysis may support histological characterization of these rare entities and potentially disclose novel therapeutic targets. MDPI 2022-09-06 /pmc/articles/PMC9498211/ /pubmed/36140560 http://dx.doi.org/10.3390/diagnostics12092160 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Interesting Images Pavone, Giuliana Romano, Chiara Martorana, Federica Motta, Lucia Salvatorelli, Lucia Zanghì, Antonio Maria Magro, Gaetano Vigneri, Paolo Giant Paratesticular Liposarcoma: Molecular Characterization and Management Principles with a Review of the Literature |
title | Giant Paratesticular Liposarcoma: Molecular Characterization and Management Principles with a Review of the Literature |
title_full | Giant Paratesticular Liposarcoma: Molecular Characterization and Management Principles with a Review of the Literature |
title_fullStr | Giant Paratesticular Liposarcoma: Molecular Characterization and Management Principles with a Review of the Literature |
title_full_unstemmed | Giant Paratesticular Liposarcoma: Molecular Characterization and Management Principles with a Review of the Literature |
title_short | Giant Paratesticular Liposarcoma: Molecular Characterization and Management Principles with a Review of the Literature |
title_sort | giant paratesticular liposarcoma: molecular characterization and management principles with a review of the literature |
topic | Interesting Images |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9498211/ https://www.ncbi.nlm.nih.gov/pubmed/36140560 http://dx.doi.org/10.3390/diagnostics12092160 |
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