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Management of Acute Myeloid Leukemia: A Review for General Practitioners in Oncology

Acute myeloid leukemia (AML) is a hematologic malignancy that most frequently develops in older adults. Overall, AML is associated with a high mortality although advancements in genetic risk stratification and new treatments are leading to improvements in outcomes for some subgroups. In this review,...

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Detalles Bibliográficos
Autores principales: Stubbins, Ryan J., Francis, Annabel, Kuchenbauer, Florian, Sanford, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9498246/
https://www.ncbi.nlm.nih.gov/pubmed/36135060
http://dx.doi.org/10.3390/curroncol29090491
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author Stubbins, Ryan J.
Francis, Annabel
Kuchenbauer, Florian
Sanford, David
author_facet Stubbins, Ryan J.
Francis, Annabel
Kuchenbauer, Florian
Sanford, David
author_sort Stubbins, Ryan J.
collection PubMed
description Acute myeloid leukemia (AML) is a hematologic malignancy that most frequently develops in older adults. Overall, AML is associated with a high mortality although advancements in genetic risk stratification and new treatments are leading to improvements in outcomes for some subgroups. In this review, we discuss an individualized approach to intensive therapy with a focus on the role of recently approved novel therapies as well as the selection of post-remission therapies for patients in first remission. We discuss the management of patients with relapsed and refractory AML, including the role of targeted treatment and allogeneic stem cell transplant. Next, we review non-intensive treatment for older and unfit AML patients including the use of azacitidine and venetoclax. Finally, we discuss the integration of palliative care in the management of patients with AML.
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spelling pubmed-94982462022-09-23 Management of Acute Myeloid Leukemia: A Review for General Practitioners in Oncology Stubbins, Ryan J. Francis, Annabel Kuchenbauer, Florian Sanford, David Curr Oncol Review Acute myeloid leukemia (AML) is a hematologic malignancy that most frequently develops in older adults. Overall, AML is associated with a high mortality although advancements in genetic risk stratification and new treatments are leading to improvements in outcomes for some subgroups. In this review, we discuss an individualized approach to intensive therapy with a focus on the role of recently approved novel therapies as well as the selection of post-remission therapies for patients in first remission. We discuss the management of patients with relapsed and refractory AML, including the role of targeted treatment and allogeneic stem cell transplant. Next, we review non-intensive treatment for older and unfit AML patients including the use of azacitidine and venetoclax. Finally, we discuss the integration of palliative care in the management of patients with AML. MDPI 2022-08-30 /pmc/articles/PMC9498246/ /pubmed/36135060 http://dx.doi.org/10.3390/curroncol29090491 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Stubbins, Ryan J.
Francis, Annabel
Kuchenbauer, Florian
Sanford, David
Management of Acute Myeloid Leukemia: A Review for General Practitioners in Oncology
title Management of Acute Myeloid Leukemia: A Review for General Practitioners in Oncology
title_full Management of Acute Myeloid Leukemia: A Review for General Practitioners in Oncology
title_fullStr Management of Acute Myeloid Leukemia: A Review for General Practitioners in Oncology
title_full_unstemmed Management of Acute Myeloid Leukemia: A Review for General Practitioners in Oncology
title_short Management of Acute Myeloid Leukemia: A Review for General Practitioners in Oncology
title_sort management of acute myeloid leukemia: a review for general practitioners in oncology
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9498246/
https://www.ncbi.nlm.nih.gov/pubmed/36135060
http://dx.doi.org/10.3390/curroncol29090491
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