Inhibitory Activity of Quaternary Isoquinoline Alkaloids on Soluble Epoxide Hydrolase

The quaternary isoquinoline alkaloids of palmatine (1), berberine (2), and jatrorrhizine (3) were evaluated in terms of their ability to inhibit soluble epoxide hydrolase (sEH). They had similar inhibitory activities, with IC(50) values of 29.6 ± 0.5, 33.4 ± 0.8, and 27.3 ± 0.4 μM, respectively. The...

Descripción completa

Detalles Bibliográficos
Autores principales: Kim, Jang Hoon, Cho, Chong Woon, Hur, Mok, Park, Woo Tae, Moon, Youn-Ho, Koo, Sung-Cheol, Hur, Yun-Chan, Kang, Jong Seong, Lee, Ik Soo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9498296/
https://www.ncbi.nlm.nih.gov/pubmed/36135206
http://dx.doi.org/10.3390/cimb44090294

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9498296/
https://www.ncbi.nlm.nih.gov/pubmed/36135206
http://dx.doi.org/10.3390/cimb44090294

Ejemplares similares