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Synthesis and Characterization of Novel Patchouli Essential Oil Loaded Starch-Based Hydrogel

Starch hydrogels are highly available, biocompatible and biodegradable materials that have promising applications in medical and pharmaceutical industries. However, their applications are very limited due to their poor mechanical properties and fragility. Here, we investigated, for the first time, c...

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Autores principales: Abdul Khalil, H. P. S., Muhammad, Syaifullah, Yahya, Esam Bashir, Amanda, Lee Kar Mun, Abu Bakar, Suriani, Abdullah, C. K., Aiman, Abd Rahim, Marwan, M., Rizal, Samsul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9498342/
https://www.ncbi.nlm.nih.gov/pubmed/36135248
http://dx.doi.org/10.3390/gels8090536
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author Abdul Khalil, H. P. S.
Muhammad, Syaifullah
Yahya, Esam Bashir
Amanda, Lee Kar Mun
Abu Bakar, Suriani
Abdullah, C. K.
Aiman, Abd Rahim
Marwan, M.
Rizal, Samsul
author_facet Abdul Khalil, H. P. S.
Muhammad, Syaifullah
Yahya, Esam Bashir
Amanda, Lee Kar Mun
Abu Bakar, Suriani
Abdullah, C. K.
Aiman, Abd Rahim
Marwan, M.
Rizal, Samsul
author_sort Abdul Khalil, H. P. S.
collection PubMed
description Starch hydrogels are highly available, biocompatible and biodegradable materials that have promising applications in medical and pharmaceutical industries. However, their applications are very limited due to their poor mechanical properties and fragility. Here, we investigated, for the first time, conventional corn and waxy corn starch-based hydrogels for loading patchouli essential oil. The essential oil extracted by supercritical carbon dioxide with a yield reached 8.37 ± 1.2 wt.% (wet sample) at 80 °C temperature and 10 MPa pressure. Patchouli essential oil exhibited a 23 to 28 mm zone of inhibition against gram-positive and gram-negative bacteria. Waxy starch hydrogels had better properties in term of viscosity, water evaporation stability and the delivery of essential oil than conventional starch hydrogels. The viscosity and spreadability of a 6% waxy starch sample were 15,016 ± 59 cP and 4.02 ± 0.34 g·cm/s, respectively, compared with those of conventional starch hydrogel (13,008 ± 29 cP and 4.59 ± 0.88 g·cm/s). Waxy starch-based hydrogels also provided slower in vitro biodegradation behavior and sustained release of essential oil compared with conventional starch hydrogels. All the samples were biocompatible and non-cytotoxic to fibroblast cells; the addition of patchouli essential oil enhances the proliferation of the cells. The enhanced viscosity, good antibacterial and improved biocompatibility results of prepared hydrogels confirm their suitability for wound healing applications.
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spelling pubmed-94983422022-09-23 Synthesis and Characterization of Novel Patchouli Essential Oil Loaded Starch-Based Hydrogel Abdul Khalil, H. P. S. Muhammad, Syaifullah Yahya, Esam Bashir Amanda, Lee Kar Mun Abu Bakar, Suriani Abdullah, C. K. Aiman, Abd Rahim Marwan, M. Rizal, Samsul Gels Article Starch hydrogels are highly available, biocompatible and biodegradable materials that have promising applications in medical and pharmaceutical industries. However, their applications are very limited due to their poor mechanical properties and fragility. Here, we investigated, for the first time, conventional corn and waxy corn starch-based hydrogels for loading patchouli essential oil. The essential oil extracted by supercritical carbon dioxide with a yield reached 8.37 ± 1.2 wt.% (wet sample) at 80 °C temperature and 10 MPa pressure. Patchouli essential oil exhibited a 23 to 28 mm zone of inhibition against gram-positive and gram-negative bacteria. Waxy starch hydrogels had better properties in term of viscosity, water evaporation stability and the delivery of essential oil than conventional starch hydrogels. The viscosity and spreadability of a 6% waxy starch sample were 15,016 ± 59 cP and 4.02 ± 0.34 g·cm/s, respectively, compared with those of conventional starch hydrogel (13,008 ± 29 cP and 4.59 ± 0.88 g·cm/s). Waxy starch-based hydrogels also provided slower in vitro biodegradation behavior and sustained release of essential oil compared with conventional starch hydrogels. All the samples were biocompatible and non-cytotoxic to fibroblast cells; the addition of patchouli essential oil enhances the proliferation of the cells. The enhanced viscosity, good antibacterial and improved biocompatibility results of prepared hydrogels confirm their suitability for wound healing applications. MDPI 2022-08-26 /pmc/articles/PMC9498342/ /pubmed/36135248 http://dx.doi.org/10.3390/gels8090536 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Abdul Khalil, H. P. S.
Muhammad, Syaifullah
Yahya, Esam Bashir
Amanda, Lee Kar Mun
Abu Bakar, Suriani
Abdullah, C. K.
Aiman, Abd Rahim
Marwan, M.
Rizal, Samsul
Synthesis and Characterization of Novel Patchouli Essential Oil Loaded Starch-Based Hydrogel
title Synthesis and Characterization of Novel Patchouli Essential Oil Loaded Starch-Based Hydrogel
title_full Synthesis and Characterization of Novel Patchouli Essential Oil Loaded Starch-Based Hydrogel
title_fullStr Synthesis and Characterization of Novel Patchouli Essential Oil Loaded Starch-Based Hydrogel
title_full_unstemmed Synthesis and Characterization of Novel Patchouli Essential Oil Loaded Starch-Based Hydrogel
title_short Synthesis and Characterization of Novel Patchouli Essential Oil Loaded Starch-Based Hydrogel
title_sort synthesis and characterization of novel patchouli essential oil loaded starch-based hydrogel
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9498342/
https://www.ncbi.nlm.nih.gov/pubmed/36135248
http://dx.doi.org/10.3390/gels8090536
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