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Hypericum perforatum and Its Potential Antiplatelet Effect
Background: Hypericum perforatum (HP) is currently one of the most consumed medicinal plants in the world. In traditional Chinese medicine, the herb hypericum (Guan Ye Lian Qiao) belongs to the group of plants that clarify heat. It is also used to treat various types of infection and inflammation. I...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9498564/ https://www.ncbi.nlm.nih.gov/pubmed/36141386 http://dx.doi.org/10.3390/healthcare10091774 |
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author | Monteiro, Maria-do-Céu Dias, Alberto C. P. Costa, Daniela Almeida-Dias, António Criado, Maria Begoña |
author_facet | Monteiro, Maria-do-Céu Dias, Alberto C. P. Costa, Daniela Almeida-Dias, António Criado, Maria Begoña |
author_sort | Monteiro, Maria-do-Céu |
collection | PubMed |
description | Background: Hypericum perforatum (HP) is currently one of the most consumed medicinal plants in the world. In traditional Chinese medicine, the herb hypericum (Guan Ye Lian Qiao) belongs to the group of plants that clarify heat. It is also used to treat various types of infection and inflammation. In contrast to the extensive literature on the antidepressant effects of HP, little is known about its action on platelets. The main objective of this work was to investigate the possible relevance of HP to platelet function. Methods: We characterized the profile of platelet activation in the presence of HP extracts through an evaluation of molecular markers by flow cytometry: mobilization of intracellular Ca++ and expression of platelet receptors such as activated GPIIbIIIa and P-selectin (CD62). Results: The results indicated a possible inhibitory effect of HP on the platelet activation response, which could be explained by the effect on intracellular calcium mobilization and the expression of activated GPIIbIIIa receptors. Despite of the limitations of an in vitro study, our results provide evidence of the possible mechanisms of action of HP. Conclusions: Further studies are needed to elucidate the effect of HP on hemostasis, but it may be recognized as a substance with antiplatelet properties. |
format | Online Article Text |
id | pubmed-9498564 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94985642022-09-23 Hypericum perforatum and Its Potential Antiplatelet Effect Monteiro, Maria-do-Céu Dias, Alberto C. P. Costa, Daniela Almeida-Dias, António Criado, Maria Begoña Healthcare (Basel) Article Background: Hypericum perforatum (HP) is currently one of the most consumed medicinal plants in the world. In traditional Chinese medicine, the herb hypericum (Guan Ye Lian Qiao) belongs to the group of plants that clarify heat. It is also used to treat various types of infection and inflammation. In contrast to the extensive literature on the antidepressant effects of HP, little is known about its action on platelets. The main objective of this work was to investigate the possible relevance of HP to platelet function. Methods: We characterized the profile of platelet activation in the presence of HP extracts through an evaluation of molecular markers by flow cytometry: mobilization of intracellular Ca++ and expression of platelet receptors such as activated GPIIbIIIa and P-selectin (CD62). Results: The results indicated a possible inhibitory effect of HP on the platelet activation response, which could be explained by the effect on intracellular calcium mobilization and the expression of activated GPIIbIIIa receptors. Despite of the limitations of an in vitro study, our results provide evidence of the possible mechanisms of action of HP. Conclusions: Further studies are needed to elucidate the effect of HP on hemostasis, but it may be recognized as a substance with antiplatelet properties. MDPI 2022-09-15 /pmc/articles/PMC9498564/ /pubmed/36141386 http://dx.doi.org/10.3390/healthcare10091774 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Monteiro, Maria-do-Céu Dias, Alberto C. P. Costa, Daniela Almeida-Dias, António Criado, Maria Begoña Hypericum perforatum and Its Potential Antiplatelet Effect |
title | Hypericum perforatum and Its Potential Antiplatelet Effect |
title_full | Hypericum perforatum and Its Potential Antiplatelet Effect |
title_fullStr | Hypericum perforatum and Its Potential Antiplatelet Effect |
title_full_unstemmed | Hypericum perforatum and Its Potential Antiplatelet Effect |
title_short | Hypericum perforatum and Its Potential Antiplatelet Effect |
title_sort | hypericum perforatum and its potential antiplatelet effect |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9498564/ https://www.ncbi.nlm.nih.gov/pubmed/36141386 http://dx.doi.org/10.3390/healthcare10091774 |
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