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Stress Hyperglycemia Ratio as a Prognostic Marker in Diabetic Patients Hospitalized with COVID-19

Evidence is conflicting about the diabetes characteristics associated with worse outcome among hospitalized COVID-19 patients. We aimed to assess the role of stress hyperglycemia ratio (SHR) as a prognostic marker among them. In our retrospective cohort study, patients were stratified according to S...

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Autores principales: Aon, Mohamed, Alsaeedi, Abdullah, Alzafiri, Azeez, Al-Shammari, Abdelrahman, Taha, Sherif, Al-Shammari, Omar, Tawakul, Mahmoud, Alshammari, Jarrah, Alherz, Naser, Alenezi, Monerah, Eyadah, Meshari, Aldhafeeri, Mariam, Alharbi, Teflah, Alshammari, Duaa, Alenezi, Zaid, Aldouseri, Salem, Albazee, Ebraheem, Ibrahim, Mohamed M., Aoun, Ahmed H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9498653/
https://www.ncbi.nlm.nih.gov/pubmed/36136823
http://dx.doi.org/10.3390/idr14050073
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author Aon, Mohamed
Alsaeedi, Abdullah
Alzafiri, Azeez
Al-Shammari, Abdelrahman
Taha, Sherif
Al-Shammari, Omar
Tawakul, Mahmoud
Alshammari, Jarrah
Alherz, Naser
Alenezi, Monerah
Eyadah, Meshari
Aldhafeeri, Mariam
Alharbi, Teflah
Alshammari, Duaa
Alenezi, Zaid
Aldouseri, Salem
Albazee, Ebraheem
Ibrahim, Mohamed M.
Aoun, Ahmed H.
author_facet Aon, Mohamed
Alsaeedi, Abdullah
Alzafiri, Azeez
Al-Shammari, Abdelrahman
Taha, Sherif
Al-Shammari, Omar
Tawakul, Mahmoud
Alshammari, Jarrah
Alherz, Naser
Alenezi, Monerah
Eyadah, Meshari
Aldhafeeri, Mariam
Alharbi, Teflah
Alshammari, Duaa
Alenezi, Zaid
Aldouseri, Salem
Albazee, Ebraheem
Ibrahim, Mohamed M.
Aoun, Ahmed H.
author_sort Aon, Mohamed
collection PubMed
description Evidence is conflicting about the diabetes characteristics associated with worse outcome among hospitalized COVID-19 patients. We aimed to assess the role of stress hyperglycemia ratio (SHR) as a prognostic marker among them. In our retrospective cohort study, patients were stratified according to SHR, admission glucose, and glycated hemoglobin tertiles. The primary outcome was a composite endpoint of invasive mechanical ventilation, intensive care unit admission, and in-hospital mortality. The study included 395 patients with a mean age of 59 years, and 50.1% were males. Patients in the third tertile of SHR developed more primary events, and the difference was significant compared to the first tertile (p = 0.038) and close to significance compared to the second tertile (p = 0.054). There was no significant difference in the outcomes across admission glucose and glycated hemoglobin tertiles. A higher SHR tertile was an independent risk factor for the primary outcome (OR, 1.364; 95% CI: 1.014–1.836; p = 0.040) after adjustment for other covariables. In hospitalized COVID-19 diabetic patients, SHR third tertile was significantly associated with worse outcome and death. SHR can be a better prognostic marker compared to admission glucose and glycated hemoglobin. A higher SHR was an independent risk factor for worse outcome and in-hospital mortality.
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spelling pubmed-94986532022-09-23 Stress Hyperglycemia Ratio as a Prognostic Marker in Diabetic Patients Hospitalized with COVID-19 Aon, Mohamed Alsaeedi, Abdullah Alzafiri, Azeez Al-Shammari, Abdelrahman Taha, Sherif Al-Shammari, Omar Tawakul, Mahmoud Alshammari, Jarrah Alherz, Naser Alenezi, Monerah Eyadah, Meshari Aldhafeeri, Mariam Alharbi, Teflah Alshammari, Duaa Alenezi, Zaid Aldouseri, Salem Albazee, Ebraheem Ibrahim, Mohamed M. Aoun, Ahmed H. Infect Dis Rep Article Evidence is conflicting about the diabetes characteristics associated with worse outcome among hospitalized COVID-19 patients. We aimed to assess the role of stress hyperglycemia ratio (SHR) as a prognostic marker among them. In our retrospective cohort study, patients were stratified according to SHR, admission glucose, and glycated hemoglobin tertiles. The primary outcome was a composite endpoint of invasive mechanical ventilation, intensive care unit admission, and in-hospital mortality. The study included 395 patients with a mean age of 59 years, and 50.1% were males. Patients in the third tertile of SHR developed more primary events, and the difference was significant compared to the first tertile (p = 0.038) and close to significance compared to the second tertile (p = 0.054). There was no significant difference in the outcomes across admission glucose and glycated hemoglobin tertiles. A higher SHR tertile was an independent risk factor for the primary outcome (OR, 1.364; 95% CI: 1.014–1.836; p = 0.040) after adjustment for other covariables. In hospitalized COVID-19 diabetic patients, SHR third tertile was significantly associated with worse outcome and death. SHR can be a better prognostic marker compared to admission glucose and glycated hemoglobin. A higher SHR was an independent risk factor for worse outcome and in-hospital mortality. MDPI 2022-09-07 /pmc/articles/PMC9498653/ /pubmed/36136823 http://dx.doi.org/10.3390/idr14050073 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Aon, Mohamed
Alsaeedi, Abdullah
Alzafiri, Azeez
Al-Shammari, Abdelrahman
Taha, Sherif
Al-Shammari, Omar
Tawakul, Mahmoud
Alshammari, Jarrah
Alherz, Naser
Alenezi, Monerah
Eyadah, Meshari
Aldhafeeri, Mariam
Alharbi, Teflah
Alshammari, Duaa
Alenezi, Zaid
Aldouseri, Salem
Albazee, Ebraheem
Ibrahim, Mohamed M.
Aoun, Ahmed H.
Stress Hyperglycemia Ratio as a Prognostic Marker in Diabetic Patients Hospitalized with COVID-19
title Stress Hyperglycemia Ratio as a Prognostic Marker in Diabetic Patients Hospitalized with COVID-19
title_full Stress Hyperglycemia Ratio as a Prognostic Marker in Diabetic Patients Hospitalized with COVID-19
title_fullStr Stress Hyperglycemia Ratio as a Prognostic Marker in Diabetic Patients Hospitalized with COVID-19
title_full_unstemmed Stress Hyperglycemia Ratio as a Prognostic Marker in Diabetic Patients Hospitalized with COVID-19
title_short Stress Hyperglycemia Ratio as a Prognostic Marker in Diabetic Patients Hospitalized with COVID-19
title_sort stress hyperglycemia ratio as a prognostic marker in diabetic patients hospitalized with covid-19
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9498653/
https://www.ncbi.nlm.nih.gov/pubmed/36136823
http://dx.doi.org/10.3390/idr14050073
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