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Stress Hyperglycemia Ratio as a Prognostic Marker in Diabetic Patients Hospitalized with COVID-19
Evidence is conflicting about the diabetes characteristics associated with worse outcome among hospitalized COVID-19 patients. We aimed to assess the role of stress hyperglycemia ratio (SHR) as a prognostic marker among them. In our retrospective cohort study, patients were stratified according to S...
Autores principales: | , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9498653/ https://www.ncbi.nlm.nih.gov/pubmed/36136823 http://dx.doi.org/10.3390/idr14050073 |
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author | Aon, Mohamed Alsaeedi, Abdullah Alzafiri, Azeez Al-Shammari, Abdelrahman Taha, Sherif Al-Shammari, Omar Tawakul, Mahmoud Alshammari, Jarrah Alherz, Naser Alenezi, Monerah Eyadah, Meshari Aldhafeeri, Mariam Alharbi, Teflah Alshammari, Duaa Alenezi, Zaid Aldouseri, Salem Albazee, Ebraheem Ibrahim, Mohamed M. Aoun, Ahmed H. |
author_facet | Aon, Mohamed Alsaeedi, Abdullah Alzafiri, Azeez Al-Shammari, Abdelrahman Taha, Sherif Al-Shammari, Omar Tawakul, Mahmoud Alshammari, Jarrah Alherz, Naser Alenezi, Monerah Eyadah, Meshari Aldhafeeri, Mariam Alharbi, Teflah Alshammari, Duaa Alenezi, Zaid Aldouseri, Salem Albazee, Ebraheem Ibrahim, Mohamed M. Aoun, Ahmed H. |
author_sort | Aon, Mohamed |
collection | PubMed |
description | Evidence is conflicting about the diabetes characteristics associated with worse outcome among hospitalized COVID-19 patients. We aimed to assess the role of stress hyperglycemia ratio (SHR) as a prognostic marker among them. In our retrospective cohort study, patients were stratified according to SHR, admission glucose, and glycated hemoglobin tertiles. The primary outcome was a composite endpoint of invasive mechanical ventilation, intensive care unit admission, and in-hospital mortality. The study included 395 patients with a mean age of 59 years, and 50.1% were males. Patients in the third tertile of SHR developed more primary events, and the difference was significant compared to the first tertile (p = 0.038) and close to significance compared to the second tertile (p = 0.054). There was no significant difference in the outcomes across admission glucose and glycated hemoglobin tertiles. A higher SHR tertile was an independent risk factor for the primary outcome (OR, 1.364; 95% CI: 1.014–1.836; p = 0.040) after adjustment for other covariables. In hospitalized COVID-19 diabetic patients, SHR third tertile was significantly associated with worse outcome and death. SHR can be a better prognostic marker compared to admission glucose and glycated hemoglobin. A higher SHR was an independent risk factor for worse outcome and in-hospital mortality. |
format | Online Article Text |
id | pubmed-9498653 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94986532022-09-23 Stress Hyperglycemia Ratio as a Prognostic Marker in Diabetic Patients Hospitalized with COVID-19 Aon, Mohamed Alsaeedi, Abdullah Alzafiri, Azeez Al-Shammari, Abdelrahman Taha, Sherif Al-Shammari, Omar Tawakul, Mahmoud Alshammari, Jarrah Alherz, Naser Alenezi, Monerah Eyadah, Meshari Aldhafeeri, Mariam Alharbi, Teflah Alshammari, Duaa Alenezi, Zaid Aldouseri, Salem Albazee, Ebraheem Ibrahim, Mohamed M. Aoun, Ahmed H. Infect Dis Rep Article Evidence is conflicting about the diabetes characteristics associated with worse outcome among hospitalized COVID-19 patients. We aimed to assess the role of stress hyperglycemia ratio (SHR) as a prognostic marker among them. In our retrospective cohort study, patients were stratified according to SHR, admission glucose, and glycated hemoglobin tertiles. The primary outcome was a composite endpoint of invasive mechanical ventilation, intensive care unit admission, and in-hospital mortality. The study included 395 patients with a mean age of 59 years, and 50.1% were males. Patients in the third tertile of SHR developed more primary events, and the difference was significant compared to the first tertile (p = 0.038) and close to significance compared to the second tertile (p = 0.054). There was no significant difference in the outcomes across admission glucose and glycated hemoglobin tertiles. A higher SHR tertile was an independent risk factor for the primary outcome (OR, 1.364; 95% CI: 1.014–1.836; p = 0.040) after adjustment for other covariables. In hospitalized COVID-19 diabetic patients, SHR third tertile was significantly associated with worse outcome and death. SHR can be a better prognostic marker compared to admission glucose and glycated hemoglobin. A higher SHR was an independent risk factor for worse outcome and in-hospital mortality. MDPI 2022-09-07 /pmc/articles/PMC9498653/ /pubmed/36136823 http://dx.doi.org/10.3390/idr14050073 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Aon, Mohamed Alsaeedi, Abdullah Alzafiri, Azeez Al-Shammari, Abdelrahman Taha, Sherif Al-Shammari, Omar Tawakul, Mahmoud Alshammari, Jarrah Alherz, Naser Alenezi, Monerah Eyadah, Meshari Aldhafeeri, Mariam Alharbi, Teflah Alshammari, Duaa Alenezi, Zaid Aldouseri, Salem Albazee, Ebraheem Ibrahim, Mohamed M. Aoun, Ahmed H. Stress Hyperglycemia Ratio as a Prognostic Marker in Diabetic Patients Hospitalized with COVID-19 |
title | Stress Hyperglycemia Ratio as a Prognostic Marker in Diabetic Patients Hospitalized with COVID-19 |
title_full | Stress Hyperglycemia Ratio as a Prognostic Marker in Diabetic Patients Hospitalized with COVID-19 |
title_fullStr | Stress Hyperglycemia Ratio as a Prognostic Marker in Diabetic Patients Hospitalized with COVID-19 |
title_full_unstemmed | Stress Hyperglycemia Ratio as a Prognostic Marker in Diabetic Patients Hospitalized with COVID-19 |
title_short | Stress Hyperglycemia Ratio as a Prognostic Marker in Diabetic Patients Hospitalized with COVID-19 |
title_sort | stress hyperglycemia ratio as a prognostic marker in diabetic patients hospitalized with covid-19 |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9498653/ https://www.ncbi.nlm.nih.gov/pubmed/36136823 http://dx.doi.org/10.3390/idr14050073 |
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