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Interleukin-17 Family Cytokines in Metabolic Disorders and Cancer

Interleukin-17 (IL-17) family cytokines are potent drivers of inflammatory responses. Although IL-17 was originally identified as a cytokine that induces protective effects against bacterial and fungal infections, IL-17 can also promote chronic inflammation in a number of autoimmune diseases. Resear...

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Autores principales: Meehan, Eileen Victoria, Wang, Kepeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9498678/
https://www.ncbi.nlm.nih.gov/pubmed/36140808
http://dx.doi.org/10.3390/genes13091643
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author Meehan, Eileen Victoria
Wang, Kepeng
author_facet Meehan, Eileen Victoria
Wang, Kepeng
author_sort Meehan, Eileen Victoria
collection PubMed
description Interleukin-17 (IL-17) family cytokines are potent drivers of inflammatory responses. Although IL-17 was originally identified as a cytokine that induces protective effects against bacterial and fungal infections, IL-17 can also promote chronic inflammation in a number of autoimmune diseases. Research in the last decade has also elucidated critical roles of IL-17 during cancer development and treatment. Intriguingly, IL-17 seems to play a role in the risk of cancers that are associated with metabolic disorders. In this review, we summarize our current knowledge on the biochemical basis of IL-17 signaling, IL-17′s involvement in cancers and metabolic disorders, and postulate how IL-17 family cytokines may serve as a bridge between these two types of diseases.
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spelling pubmed-94986782022-09-23 Interleukin-17 Family Cytokines in Metabolic Disorders and Cancer Meehan, Eileen Victoria Wang, Kepeng Genes (Basel) Review Interleukin-17 (IL-17) family cytokines are potent drivers of inflammatory responses. Although IL-17 was originally identified as a cytokine that induces protective effects against bacterial and fungal infections, IL-17 can also promote chronic inflammation in a number of autoimmune diseases. Research in the last decade has also elucidated critical roles of IL-17 during cancer development and treatment. Intriguingly, IL-17 seems to play a role in the risk of cancers that are associated with metabolic disorders. In this review, we summarize our current knowledge on the biochemical basis of IL-17 signaling, IL-17′s involvement in cancers and metabolic disorders, and postulate how IL-17 family cytokines may serve as a bridge between these two types of diseases. MDPI 2022-09-13 /pmc/articles/PMC9498678/ /pubmed/36140808 http://dx.doi.org/10.3390/genes13091643 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Meehan, Eileen Victoria
Wang, Kepeng
Interleukin-17 Family Cytokines in Metabolic Disorders and Cancer
title Interleukin-17 Family Cytokines in Metabolic Disorders and Cancer
title_full Interleukin-17 Family Cytokines in Metabolic Disorders and Cancer
title_fullStr Interleukin-17 Family Cytokines in Metabolic Disorders and Cancer
title_full_unstemmed Interleukin-17 Family Cytokines in Metabolic Disorders and Cancer
title_short Interleukin-17 Family Cytokines in Metabolic Disorders and Cancer
title_sort interleukin-17 family cytokines in metabolic disorders and cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9498678/
https://www.ncbi.nlm.nih.gov/pubmed/36140808
http://dx.doi.org/10.3390/genes13091643
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